DRSC/TRiP Functional Genomics Resources

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Protein Alignment LDLR and Ndg

DIOPT Version :10

Sequence 1:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens
Sequence 2:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster


Alignment Length:895 Identity:208/895 - (23%)
Similarity:312/895 - (34%) Gaps:301/895 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    15 LLAAAGTAVGDRCERNEFQCQDGK--------CISYK--WVCDGSAECQDG-----SDESQETCL 64
            |...|.:.||...|.|  .|.||.        |:.|:  :.||    |..|     .:...|.||
  Fly   532 LRIGAMSKVGVTPESN--ACNDGTADCVENSVCVPYEDTYRCD----CYHGFAAQLDERGVEVCL 590

Human    65 SV-TCKSGDFSC----------GGRVNRCIPQF----WRC---------------DGQVD----- 94
            .: .|.:|...|          ||....|...|    :||               :||.:     
  Fly   591 DIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTADNIEYPPAVEGQAEPTSEP 655

Human    95 -------CDNGSDEQ------GCP---PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
                   .|.|.|::      ..|   |....:::...|..:|    :.|..|.||..|    .|
  Fly   656 SPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPDEC----YRCSKDADCYQG----RC 712

Human   144 PVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP-CSAFEFHCLSG 207
               || ...|..:..||..   .|.:....|:|      ||..|.:.:.|..| |.|.      |
  Fly   713 ---TC-HEGFDGDGYTCTN---ICGHGEVWENG------RCEPLLLERHDVDPLCDAL------G 758

Human   208 ECIHSSWRCDGGPDCKDKSD---------------------EENC--------------AVATCR 237
            ||     ||..|.:..:.|.                     :|||              .:.||:
  Fly   759 EC-----RCPYGYELSEDSQRCTYVQEFDGERNADLIPCDVDENCHINATCNWYGQELRHICTCQ 818

Human   238 P----DEFQC---SDGNCIHGSRQCDREYDCKDMSDEVG---CVNVTLCEG---PNKFKC----- 284
            |    |.:.|   ||.:|......||...||. ..:.:|   |    .|:.   .|.|.|     
  Fly   819 PGFRGDGYNCDPISDDSCAIRPDICDVHADCV-YEEHLGKSEC----QCQAGYTGNGFNCQLAAE 878

Human   285 -----HSGE-CITLDKVCNMARDC-RDWSDEPIKE-------CGTN--------------ECLDN 321
                 |.|| ....|.||....|. ||.||..:..       ||:|              :|||.
  Fly   879 CQSAEHCGENAFCDDGVCRCQADFERDVSDRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDG 943

Human   322 -NG----GCS------HVCNDLKI-----------GYECLC-----PDGFQLVAQRRCEDIDECQ 359
             .|    ||:      ||.|:..|           .|||.|     .||:..:.::.|     ..
  Fly   944 YQGDALTGCTSKPLSCHVLNNCGIHATCEPTEDPANYECQCIAGFKGDGYVCIEEQNC-----LN 1003

Human   360 DPDTC--SQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRK-MTLDRSEYTS 421
            :|..|  :..|.:...|..|.|.:||         ...||:..   ..:|:... :.:.:....:
  Fly  1004 NPTLCDMNAQCRSTNSGLVCVCNQGF---------FGNGSLCQ---ERQHQDSDFLIVSQGVMIA 1056

Human   422 LIP-NLRNV---------VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAP 476
            .:| |.|||         :.||.:....|:||.|:|.:.|.||:.|.    :.....|:.||::|
  Fly  1057 RVPLNGRNVRPISVAQMAIGLDKDCVEGRVYWGDISTKKIVSTKYDG----TDLRPFITTDIESP 1117

Human   477 DGLAVDWIHSNIYWTDSVLGTVSVADTKGVK-RKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA 540
            :|:|:|.|...:||.||...|:.||...... |..:..:....||.|.|||....::|:||...:
  Fly  1118 EGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRES 1182

Human   541 -KIKKGGLNGVDIYSLV-TENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEK 603
             ||:...|:|.....|: .:::..||.:.:...||.:.:.|:....:..|:......:||   ..
  Fly  1183 PKIEMSNLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTI---SN 1244

Human   604 RLAHPFSLAVFEDKVFWTD-----------------IINEAIFSANRLTGSDVNLLAENLLSPED 651
            .|::||.:....|:.:|||                 .|....|.::::.|..|            
  Fly  1245 ELSYPFGITFTHDQFYWTDWTTKKVEIVDSLGARQTPIQPPFFGSHKMYGMTV------------ 1297

Human   652 MVLFHNLTQPRGVNWCERTTLSNGGC--QYLCLPAPQINPHSPK-FTCAC 698
             |..|   .|:..:.|:   :|||||  ..|||    :|..:|. .:|.|
  Fly  1298 -VEQH---CPQYQSPCQ---ISNGGCTDSRLCL----VNRQAPSGKSCKC 1336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 11/47 (23%)
Ldl_recept_a 66..104 CDD:395011 14/85 (16%)
Ldl_recept_a 107..143 CDD:395011 7/35 (20%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 25/122 (20%)
Ldl_recept_a 147..179 CDD:395011 8/31 (26%)
Ldl_recept_a 195..231 CDD:395011 11/57 (19%)
Ldl_recept_a 235..270 CDD:395011 13/44 (30%)
Ldl_recept_a 278..308 CDD:395011 13/44 (30%)
FXa_inhibition 318..>346 CDD:464251 16/54 (30%)
EGF_CA 354..388 CDD:214542 8/35 (23%)
LDL-receptor class B 1 397..438 9/51 (18%)
LY 419..457 CDD:214531 15/47 (32%)
LDL-receptor class B 2 439..485 16/45 (36%)
Ldl_recept_b 439..483 CDD:459654 15/43 (35%)
LDL-receptor class B 3 486..528 14/42 (33%)
Ldl_recept_b 487..526 CDD:459654 12/39 (31%)
LDL-receptor class B 4 529..572 10/44 (23%)
Ldl_recept_b 529..569 CDD:459654 10/41 (24%)
LY 553..595 CDD:214531 7/42 (17%)
LDL-receptor class B 5 573..615 8/41 (20%)
LDL-receptor class B 6 616..658 10/58 (17%)
Ldl_recept_b 616..656 CDD:459654 9/56 (16%)
FXa_inhibition 671..711 CDD:464251 12/31 (39%)
Clustered O-linked oligosaccharides 721..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828
NdgNP_610575.1 NIDO 108..262 CDD:214712
EGF_3 285..320 CDD:463759
G2F 322..549 CDD:214774 6/18 (33%)
EGF_CA 591..622 CDD:429571 6/30 (20%)
EGF_3 797..828 CDD:463759 6/30 (20%)
EGF_3 836..873 CDD:463759 10/41 (24%)
EGF_3 963..995 CDD:463759 8/31 (26%)
EGF_3 1001..1036 CDD:463759 11/48 (23%)
NHL 1074..>1254 CDD:302697 52/186 (28%)
NHL repeat 1074..1112 CDD:271320 12/41 (29%)
LY 1107..1145 CDD:214531 15/37 (41%)
NHL repeat 1117..1156 CDD:271320 13/38 (34%)
LY 1152..1195 CDD:214531 13/42 (31%)
NHL repeat 1161..1202 CDD:271320 14/40 (35%)
NHL repeat 1210..1244 CDD:271320 6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

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