Sequence 1: | NP_000518.1 | Gene: | LDLR / 3949 | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001260800.2 | Gene: | LRP1 / 35799 | FlyBaseID: | FBgn0053087 | Length: | 4752 | Species: | Drosophila melanogaster |
Alignment Length: | 768 | Identity: | 257/768 - (33%) |
---|---|---|---|
Similarity: | 372/768 - (48%) | Gaps: | 117/768 - (15%) |
- Green bases have known domain annotations that are detailed below.
Human 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFS---CGGRVNRCIPQFWRCDGQV 93
Human 94 DCDNGSDEQGCPPKT---CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQC 155
Human 156 NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC-LSGECIHSSWRCDGG 219
Human 220 PDCK----DKSDEE---NCA----VATCRP---------------------------DEF----- 241
Human 242 --------------QCSDGNCIHGSRQCDREYDCKDMSDEVG--CVNVTLCEGPNKFKCHSGECI 290
Human 291 TLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLV--AQRRCE 353
Human 354 DIDECQDPDTCSQLCVNLEGGYKCQCEEGFQL-DPHTKACKAVGSIAY-LFFTNRHEVRKMTLDR 416
Human 417 SEYTSLIPNLRNVVALDTEVASNRIYWSDLSQ-----RMICSTQLDRAHGVSSYDTVISRDIQAP 476
Human 477 DGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK 541
Human 542 IKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDE---- 602
Human 603 KRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH--NLTQPRGVN 665
Human 666 WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 11/25 (44%) |
Ldl_recept_a | 66..104 | CDD:278486 | 16/40 (40%) | ||
Ldl_recept_a | 107..143 | CDD:278486 | 17/38 (45%) | ||
Ldl_recept_a | 147..179 | CDD:278486 | 16/31 (52%) | ||
Ldl_recept_a | 195..231 | CDD:278486 | 16/43 (37%) | ||
Ldl_recept_a | 235..270 | CDD:278486 | 18/82 (22%) | ||
LDLa | 278..308 | CDD:294076 | 12/29 (41%) | ||
FXa_inhibition | 318..>346 | CDD:291342 | 11/27 (41%) | ||
EGF_CA | 354..388 | CDD:214542 | 18/34 (53%) | ||
LDL-receptor class B 1 | 397..438 | 13/41 (32%) | |||
LY | 419..457 | CDD:214531 | 14/42 (33%) | ||
LDL-receptor class B 2 | 439..485 | 14/50 (28%) | |||
Ldl_recept_b | 439..482 | CDD:278487 | 11/47 (23%) | ||
LDL-receptor class B 3 | 486..528 | 16/41 (39%) | |||
Ldl_recept_b | 487..525 | CDD:278487 | 15/37 (41%) | ||
LDL-receptor class B 4 | 529..572 | 12/42 (29%) | |||
Ldl_recept_b | 529..569 | CDD:278487 | 12/39 (31%) | ||
LY | 553..595 | CDD:214531 | 11/41 (27%) | ||
LDL-receptor class B 5 | 573..615 | 13/45 (29%) | |||
LDL-receptor class B 6 | 616..658 | 9/43 (21%) | |||
Ldl_recept_b | 616..655 | CDD:278487 | 7/38 (18%) | ||
FXa_inhibition | 671..711 | CDD:291342 | 12/39 (31%) | ||
Clustered O-linked oligosaccharides | 721..768 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 734..755 | ||||
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 | 811..860 | ||||
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 | 823..828 | ||||
LRP1 | NP_001260800.2 | LDLa | 87..118 | CDD:197566 | |
LDLa | 126..163 | CDD:238060 | |||
EGF_CA | 246..283 | CDD:214542 | |||
Ldl_recept_b | 449..487 | CDD:278487 | |||
LY | 472..513 | CDD:214531 | |||
LY | 817..852 | CDD:214531 | |||
LDLa | 1057..1092 | CDD:197566 | |||
LDLa | 1104..1134 | CDD:238060 | |||
FXa_inhibition | 1289..1317 | CDD:291342 | |||
LY | 1434..1476 | CDD:214531 | |||
LY | 1477..1521 | CDD:214531 | |||
LY | 1533..1567 | CDD:214531 | |||
LY | 1568..1611 | CDD:214531 | |||
FXa_inhibition | 1639..1676 | CDD:291342 | |||
LY | 1794..1838 | CDD:214531 | |||
LY | 2078..2112 | CDD:214531 | |||
NHL | <2082..>2152 | CDD:302697 | |||
NHL repeat | 2082..2120 | CDD:271320 | |||
FXa_inhibition | 2269..2303 | CDD:291342 | |||
LY | 2430..2471 | CDD:214531 | |||
LY | 2475..2517 | CDD:214531 | |||
LDLa | 2630..2661 | CDD:238060 | |||
LDLa | 2671..2702 | CDD:238060 | |||
LDLa | 2727..2759 | CDD:238060 | 13/30 (43%) | ||
LDLa | 2773..2802 | CDD:238060 | 14/29 (48%) | ||
LDLa | 2810..2844 | CDD:238060 | 16/33 (48%) | ||
LDLa | 2848..2878 | CDD:238060 | 16/30 (53%) | ||
LDLa | 2887..2916 | CDD:197566 | 13/28 (46%) | ||
LDLa | 2938..2969 | CDD:197566 | 2/30 (7%) | ||
LDLa | 2989..3015 | CDD:197566 | 12/25 (48%) | ||
LDLa | 3030..3061 | CDD:238060 | 13/32 (41%) | ||
EGF_CA | 3062..>3091 | CDD:214542 | 12/29 (41%) | ||
EGF_CA | 3103..3141 | CDD:214542 | 20/39 (51%) | ||
LY | 3212..3254 | CDD:214531 | 17/41 (41%) | ||
LY | 3255..3297 | CDD:214531 | 15/41 (37%) | ||
LY | 3299..3340 | CDD:214531 | 11/40 (28%) | ||
LY | 3354..3389 | CDD:214531 | 10/34 (29%) | ||
LDLa | 3458..3490 | CDD:238060 | 2/4 (50%) | ||
LDLa | 3499..3533 | CDD:238060 | |||
LDLa | 3582..3616 | CDD:238060 | |||
LDLa | 3621..3652 | CDD:197566 | |||
LDLa | 3663..3697 | CDD:238060 | |||
LDLa | 3702..3736 | CDD:238060 | |||
LDLa | 3776..3808 | CDD:197566 | |||
LDLa | 3818..3849 | CDD:197566 | |||
LDLa | 3860..3894 | CDD:238060 | |||
NHL | 4029..>4158 | CDD:302697 | |||
NHL repeat | 4034..4074 | CDD:271320 | |||
NHL repeat | 4076..4115 | CDD:271320 | |||
LY | 4108..4150 | CDD:214531 | |||
NHL repeat | 4121..4158 | CDD:271320 | |||
EGF_CA | <4386..4414 | CDD:238011 | |||
EGF_CA | 4415..4450 | CDD:238011 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.910 |