Protein Alignment LDLR and CG6739

DIOPT Version :9

• Sequence 1: NP_000518.1
• Gene: LDLR / 3949
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_609130.1
• Gene: CG6739 / 34037
• FlyBaseID: FBgn0031926
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 78/354 - (22%)
• Similarity: 109/354 - (30%)
• Gaps: 158/354 - (44%)

Human    25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRC 89
            |.|..|||||.||.||...|.||...:||.|.|| .|.||
  Fly   430 DYCYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDE-DEQCL------------------------- 468

Human    90 DGQVDCDNGSDEQGCPPKTCSQDEFRCHDG-KCISRQFVCDSDRDCLDGSDEASCPVLTCGP-AS 152
                              .|..|||||... ||:..::.||.:.||:|||||..|.....|. |.
  Fly   469 ------------------VCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSDEQDCDEYGSGDLAP 515

Human   153 FQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVF-----QGDSSPCSAFEFHCLSGEC--I 210
            |..:.....|:::...:.....:.:|:       :|.:     ..|:...:.|:.|.::...  :
  Fly   516 FDESELNAFPRVFTYASFLSPNETNDK-------VYTYITATTDEDAGTETKFQIHQVAAPAPPV 573

Human   211 HSS-WRCDGGP-------DCKD---KSDEE----------------------------------- 229
            :|| ....|||       |.|:   .||.|
  Fly   574 NSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPSS 638

Human   230 ----------------------------------------NCAVAT------------CRPDEFQ 242
                                                    |.|.:.            |.|.|.:
  Fly   639 ALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAATSEPNPYEVVTSLGGCPPQELR 703

Human   243 CSDGNCIHGSRQCDREYDCKDMSDEVGCV 271
            |..|.||..|:.||::.||.|.:||:.||
  Fly   704 CVSGKCITVSQLCDKQIDCPDAADELMCV 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	17/32 (53%)
		Ldl_recept_a	66..104	CDD:278486	0/37 (0%)
		Ldl_recept_a	107..143	CDD:278486	17/36 (47%)
		Ldl_recept_a	147..179	CDD:278486	4/32 (13%)
		Ldl_recept_a	195..231	CDD:278486	12/123 (10%)
		Ldl_recept_a	235..270	CDD:278486	15/46 (33%)
		LDLa	278..308	CDD:294076
		FXa_inhibition	318..>346	CDD:291342
		EGF_CA	354..388	CDD:214542
		LDL-receptor class B 1	397..438
		LY	419..457	CDD:214531
		LDL-receptor class B 2	439..485
		Ldl_recept_b	439..482	CDD:278487
		LDL-receptor class B 3	486..528
		Ldl_recept_b	487..525	CDD:278487
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:278487
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..655	CDD:278487
		FXa_inhibition	671..711	CDD:291342
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269|PubMed:22509010	823..828
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549
		LDLa	432..464	CDD:238060	18/32 (56%)
		LDLa	470..505	CDD:238060	17/34 (50%)
		LDLa	697..731	CDD:238060	15/33 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900