DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LDLR and Lrp4

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	955	Identity:	283/955 - (29%)
Similarity:	424/955 - (44%)	Gaps:	207/955 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    50 AECQDGSDESQETC---------LSVTC-KSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC 104
            :.||: |:||.|.|         |...| |:|......|..|||.::|.|||..||.:.|||..|
  Fly   198 SNCQN-SNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHC 261

Human   105 PPKT-CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACD 168
            ..:| |:.|:|.|.:|.||.|.:|||.:.||.|.|||..|...||....|.||...||...:.||
  Fly   262 GARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCD 326

Human   169 NDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL---------SGECIHSSWRCDGGPDCKD 224
            .:.||.|.|||  .:|..:.      :.|...||.|.         ||:||.:.:||||..||.|
  Fly   327 GEHDCNDNSDE--LKCAAVI------NSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGD 383

Human   225 KSDEENC--AVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV----TLCEGPNKFK 283
            .||||||  ..:.|..:|::|:||.||....:||:|.||....||..|.::    .|..|.::|.
  Fly   384 WSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFT 448

Human   284 CHSGECITLDKVCNMARDCRDWSDE--------------PIKE--------------C-GTNEC- 318
            |::|.||....:|:...||....||              |.|:              | |.|||
  Fly   449 CNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECP 513

Human   319 -------------LDNNGGCSHVCNDLKIG-YECLCPDGFQLVAQR-RCEDIDECQ--DPDTCSQ 366
                         ......|..:|.:...| .||.|..|:.:...: .|.||||||  ....|||
  Fly   514 AGEDEADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQ 578

Human   367 LCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431
            .|.|..|.:||.||.|:.|.|..::|||:|....|...||.::|::||..:.|::::..|.|.:|
  Fly   579 KCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIA 643

Human   432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLG 496
            ||.......::|||:|..:|   ::...:|....| ||...:::|.|:||||||..::||||...
  Fly   644 LDFHHRKGLMFWSDVSTDVI---KMVYMNGTRVRD-VIKWGLESPGGIAVDWIHDLLFWTDSGTR 704

Human   497 TVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQ 561
            .|.|::.:|..|..:...:..|||||||.|.....:|:|||...||::..::|.....::::.:.
  Fly   705 RVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVT 769

Human   562 WPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINE 626
            ||||:.:|..:.::||.|:|.|:|...:::|.:|..||  ...|.|||:|.:|||.::|||...:
  Fly   770 WPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTK 832

Human   627 AIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLS-NGGCQYLCLPAPQINPH 690
            .:.:|:::||.:...:.||...|.|:..:|...||...:.|::.... .|||.:||||    |..
  Fly   833 TVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLP----NKT 893

Human   691 SPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLK------------------------- 730
            |.:  |.||.|:.|..|.::|.:.|:..|.......:||:
  Fly   894 SRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAV 956

Human   731 ---------------VSSTAVRTQH------------TTTRPVP-----DTSRLPGATPGLTTVE 763
                           |..:.:...|            ....||.     .|.:|....|....:|
  Fly   957 ALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIE 1021

Human   764 IVTMSHQALGDVAGRGN-----EK--KPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSI 821
            :.|.:        |:..     ||  ||..:    :|.||        ..|:.|.:|.
  Fly  1022 VATTN--------GKMRTLLIWEKLYKPRDI----VVNPI--------EGFMFWSDWG------- 1059

Human   822 NFDNPVYQKTTEDEVHICHNQDGYS----------YPSRQMVSLE 856
              |:|:.::.         |.||:.          ||:...:..|
  Fly  1060 --DDPMIERA---------NMDGHERVTITSKKLIYPNGLAIDYE 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	3/7 (43%)
		Ldl_recept_a	66..104	CDD:278486	16/38 (42%)
		Ldl_recept_a	107..143	CDD:278486	18/36 (50%)
		Ldl_recept_a	147..179	CDD:278486	13/31 (42%)
		Ldl_recept_a	195..231	CDD:278486	19/44 (43%)
		Ldl_recept_a	235..270	CDD:278486	14/34 (41%)
		LDLa	278..308	CDD:294076	9/29 (31%)
		FXa_inhibition	318..>346	CDD:291342	8/42 (19%)
		EGF_CA	354..388	CDD:214542	18/35 (51%)
		LDL-receptor class B 1	397..438		12/40 (30%)
		LY	419..457	CDD:214531	11/37 (30%)
		LDL-receptor class B 2	439..485		15/45 (33%)
		Ldl_recept_b	439..482	CDD:278487	12/42 (29%)
		LDL-receptor class B 3	486..528		16/41 (39%)
		Ldl_recept_b	487..525	CDD:278487	14/37 (38%)
		LDL-receptor class B 4	529..572		12/42 (29%)
		Ldl_recept_b	529..569	CDD:278487	11/39 (28%)
		LY	553..595	CDD:214531	12/41 (29%)
		LDL-receptor class B 5	573..615		15/41 (37%)
		LDL-receptor class B 6	616..658		12/41 (29%)
		Ldl_recept_b	616..655	CDD:278487	11/38 (29%)
		FXa_inhibition	671..711	CDD:291342	15/40 (38%)
		Clustered O-linked oligosaccharides	721..768		11/103 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755		5/37 (14%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860		9/56 (16%)
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828		2/4 (50%)
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	17/33 (52%)
		LDLa	306..340	CDD:238060	14/35 (40%)
		LDLa	347..390	CDD:238060	19/42 (45%)
		LDLa	397..431	CDD:238060	14/33 (42%)
		LDLa	442..476	CDD:238060	11/33 (33%)
		LDLa	480..521	CDD:238060	7/40 (18%)
		FXa_inhibition	576..604	CDD:291342	13/27 (48%)
		LY	634..671	CDD:214531	10/39 (26%)
		NHL	<656..793	CDD:302697	49/140 (35%)
		LY	680..714	CDD:214531	14/33 (42%)
		NHL repeat	681..722	CDD:271320	16/40 (40%)
		NHL repeat	726..760	CDD:271320	15/33 (45%)
		LY	761..803	CDD:214531	12/41 (29%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	15/35 (43%)
		LY	946..985	CDD:214531	2/38 (5%)
		NHL	<967..1142	CDD:302697	28/165 (17%)
		LY	988..1030	CDD:214531	8/49 (16%)
		NHL repeat	998..1037	CDD:271320	8/46 (17%)
		NHL repeat	1038..1080	CDD:271320	13/71 (18%)
		NHL repeat	1084..1119	CDD:271320	3/10 (30%)
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810