DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LDLR and yl

DIOPT Version :10

Sequence 1:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:932 Identity:274/932 - (29%)
Similarity:432/932 - (46%) Gaps:206/932 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    12 VALLL---AAAGTAVG------DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT 67
            ::|||   ...|||.|      .||:..:|||:||.||....:|||..:|:|.|||         
  Fly    66 ISLLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE--------- 121

Human    68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDR 132
                 ..|..|:  |.|..|                   ..|:|..     |.|::.:.:|:...
  Fly   122 -----LDCDYRL--CRPPHW-------------------FPCAQPH-----GACLAAELMCNGID 155

Human   133 DCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS-- 195
            :|..|.||.:|||                                       |..:.| ||::  
  Fly   156 NCPGGEDELNCPV---------------------------------------RPGFRF-GDTAHR 180

Human   196 --PCSAFEFHCLSGE-CIHSSWRCDGGPDCKDKSDE-ENC--AVATCRPDEFQCSDGNCIHGSR- 253
              .||.:||.|.... ||...:.|||.|||.||||| ..|  |..||..:...|::|.|:...: 
  Fly   181 MRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQW 245

Human   254 QCDREYDCKDMSDEVGCVNVTLCE-GPNKFKCHSGE-CITLDKVCNMARDCRDWSDE-------P 309
            .||...||.|.|||.||:|  ||| ...||.|.:.| |:||.:||:...||.|.|||       |
  Fly   246 VCDGVDDCGDGSDERGCLN--LCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP 308

Human   310 IKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVA-QRRCEDIDECQD-PDTCSQLCVNLE 372
              :|...:|.  .|...|:..  ..|.||.||.||:|.. :.:|||:|||:: .|.|||.|.|..
  Fly   309 --DCDAKKCA--LGAKCHMMP--ASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTS 367

Human   373 GGYKCQCEEGFQLDPHTKACKAV--GS---IAYLFFTNRHEVRKMTLD----RSEYTSLIPNLRN 428
            |||:|.|:.|:.||...:.|:||  ||   ...|.:|.:..:..|.|.    |:....:..||..
  Fly   368 GGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSK 432

Human   429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHG-VSSYDTVISRDIQAPDGLAVDWIHSNIYWTD 492
            |:.:..:  .:.|||:::...   :..:.:|:| .|:.:.:::..:.||:.|||||:..|||::|
  Fly   433 VIGVAYD--GSHIYWTNIQNE---AESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSD 492

Human   493 SVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVT 557
            :::..::|....|:....|..::..:||::.|.|..|.|:|||||....|.:..::|.....:|:
  Fly   493 NIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVS 557

Human   558 ENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTD 622
            :||:|||||.||:...|:||||:||.|:.::..:|..|:|:|:.  .|.||:.||:|||:::|:|
  Fly   558 DNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSD 620

Human   623 IINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA-PQ 686
            ...:::.:.::.:|.|..:||:: .:...:.::|...||...:.||..|     |.:|||.| |:
  Fly   621 WATKSVHACHKFSGKDHRILAKD-RTIYAVHIYHPAKQPNSPHGCENAT-----CSHLCLLAEPE 679

Human   687 INPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAV-RTQHTTTRPVPDT- 749
            |..||    |||||||.||.|.|.|:...:..........|.|::..||. |.|.:.:..:|.. 
  Fly   680 IGGHS----CACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLI 740

Human   750 -----SRLPGA-----TPGLTTVEIVTMSHQA-------LGDVAGRG----------NEKKPSSV 787
                 :|:.|:     ......:|....||::       ||:|:...          .:.:.:.:
  Fly   741 NEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVI 805

Human   788 RALSI--------------VLPIVLLVFLCLG-VFLLWKNWRLKNINSINFDNPVYQKTTEDEVH 837
            ..||:              .:||.|.|....| ::::.|..|..:|:.|    |:..|  .::||
  Fly   806 EVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDKI----PLSGK--GEQVH 864

Human   838 ICHNQDGYSYPSRQMVSLEDDV 859
            :..:..|           :||:
  Fly   865 VFEDDLG-----------DDDI 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 15/32 (47%)
Ldl_recept_a 66..104 CDD:395011 5/37 (14%)
Ldl_recept_a 107..143 CDD:395011 9/35 (26%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 23/94 (24%)
Ldl_recept_a 147..179 CDD:395011 0/31 (0%)
Ldl_recept_a 195..231 CDD:395011 18/41 (44%)
Ldl_recept_a 235..270 CDD:395011 13/35 (37%)
Ldl_recept_a 278..308 CDD:395011 13/30 (43%)
FXa_inhibition 318..>346 CDD:464251 10/27 (37%)
EGF_CA 354..388 CDD:214542 18/34 (53%)
LDL-receptor class B 1 397..438 9/47 (19%)
LY 419..457 CDD:214531 6/37 (16%)
LDL-receptor class B 2 439..485 13/46 (28%)
Ldl_recept_b 439..483 CDD:459654 11/44 (25%)
LDL-receptor class B 3 486..528 11/41 (27%)
Ldl_recept_b 487..526 CDD:459654 10/38 (26%)
LDL-receptor class B 4 529..572 19/42 (45%)
Ldl_recept_b 529..569 CDD:459654 17/39 (44%)
LY 553..595 CDD:214531 19/41 (46%)
LDL-receptor class B 5 573..615 17/41 (41%)
LDL-receptor class B 6 616..658 8/41 (20%)
Ldl_recept_b 616..656 CDD:459654 7/39 (18%)
FXa_inhibition 671..711 CDD:464251 21/40 (53%)
Clustered O-linked oligosaccharides 721..768 10/58 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755 6/27 (22%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860 11/49 (22%)
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828 1/4 (25%)
ylNP_996433.1 LDLa 90..124 CDD:238060 16/47 (34%)
LDLa 131..166 CDD:238060 11/58 (19%)
LDLa 184..216 CDD:238060 16/31 (52%)
LDLa 227..262 CDD:238060 12/34 (35%)
LDLa 271..302 CDD:238060 15/30 (50%)
FXa_inhibition 352..387 CDD:464251 15/34 (44%)
Ldl_recept_b 442..483 CDD:459654 11/43 (26%)
LY 466..508 CDD:214531 13/41 (32%)
Ldl_recept_b 529..569 CDD:459654 17/39 (44%)
LY 553..595 CDD:214531 19/41 (46%)
LY 596..637 CDD:214531 13/42 (31%)
FXa_inhibition 669..700 CDD:464251 20/34 (59%)
LY 774..815 CDD:214531 5/40 (13%)
LDLa 1032..1062 CDD:238060
LDLa 1074..1109 CDD:238060
LDLa 1118..1152 CDD:238060
LDLa 1157..1189 CDD:197566
LDLa 1198..1232 CDD:238060
LDLa 1243..1279 CDD:238060
LDLa 1283..1318 CDD:238060
LDLa 1340..1371 CDD:197566
FXa_inhibition 1388..1416 CDD:464251
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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