DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LDLR and Ldlr

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_786938.2	Gene:	Ldlr / 300438	RGDID:	2998	Length:	879	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	661/874 - (75%)
Similarity:	732/874 - (83%)	Gaps:	23/874 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     8 LRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGD 72
            |||.:||||||||.|..|.|.:|||||:|||||..|||||||.||.||||||.|||:||||:||:
  Rat     8 LRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGE 72

Human    73 FSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
            |||||||:||||..|||||:.||:|||||..|.|||||.|||||.||||||||||||.|.|||||
  Rat    73 FSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDG 137

Human   138 SDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGL-YVFQGDSSPCSAFE 201
            ||||.|...|||||.|:||||:|||.|||||.|.||:||||||||.|.|. ...:..|||||:.|
  Rat   138 SDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGGRDTAAEVVSSPCSSLE 202

Human   202 FHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
            |||.|.||||.||.|||..|||||||||||||.|||||||||:||:|||||||||||:|||||||
  Rat   203 FHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSD 267

Human   267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCND 331
            |:||:|||.|:|||||||||||||:||||||.|||||||||||||||.|||||||||||||:|.|
  Rat   268 ELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKD 332

Human   332 LKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVG 396
            ||||||||||.||:||...:||||||||:|||||||||||||.:||:|..||.:||||:.|||||
  Rat   333 LKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVG 397

Human   397 SIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG 461
            ||.:|.||||||||||||||||||||||||:||||||||||:|||||||||||.|.|..:|:  |
  Rat   398 SIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQ--G 460

Human   462 VS-SYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVD 525
            .| |||.:||.|:.|||||||||||.||||||||.|||||||||||:|:|||||.||:|||||||
  Rat   461 TSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVD 525

Human   526 PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV 590
            |||||||||||||||||||||||||||||||||:|||||||||||.|||||||||||||||||||
  Rat   526 PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDV 590

Human   591 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLF 655
            |||.|||||||||:||||||||::||||:|||::|||||||||||||||||:|:||:||||:|||
  Rat   591 NGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLF 655

Human   656 HNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA 720
            ||:||||||||||.|.|.||||||:|||||||:.||||||||||||||||:||||||.|.:....
  Rat   656 HNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPT 720

Human   721 TQETSTVRLKVSSTAV-------------------RTQHTTTRPVPDTSRLPGATPGLTTVEIVT 766
            ||.|||:...|:::|.                   .|:|........|||.||.||.|:|||.||
  Rat   721 TQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHKEDPSATSTSRQPGDTPELSTVESVT 785

Human   767 MSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKT 831
            :|.|..||:||||:|.:...|..|||.|||.|:..|..|..|||:||||:|||||||||||||||
  Rat   786 VSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKT 850

Human   832 TEDEVHICHNQDGYSYPSRQMVSLEDDVA 860
            ||||:|||.:||||:||||||||||||||
  Rat   851 TEDEIHICRSQDGYTYPSRQMVSLEDDVA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	24/32 (75%)
		Ldl_recept_a	66..104	CDD:278486	28/37 (76%)
		Ldl_recept_a	107..143	CDD:278486	31/35 (89%)
		Ldl_recept_a	147..179	CDD:278486	24/31 (77%)
		Ldl_recept_a	195..231	CDD:278486	27/35 (77%)
		Ldl_recept_a	235..270	CDD:278486	30/34 (88%)
		LDLa	278..308	CDD:294076	27/29 (93%)
		FXa_inhibition	318..>346	CDD:291342	24/27 (89%)
		EGF_CA	354..388	CDD:214542	25/33 (76%)
		LDL-receptor class B 1	397..438		36/40 (90%)
		LY	419..457	CDD:214531	31/37 (84%)
		LDL-receptor class B 2	439..485		31/46 (67%)
		Ldl_recept_b	439..482	CDD:278487	28/43 (65%)
		LDL-receptor class B 3	486..528		35/41 (85%)
		Ldl_recept_b	487..525	CDD:278487	32/37 (86%)
		LDL-receptor class B 4	529..572		41/42 (98%)
		Ldl_recept_b	529..569	CDD:278487	38/39 (97%)
		LY	553..595	CDD:214531	39/41 (95%)
		LDL-receptor class B 5	573..615		38/41 (93%)
		LDL-receptor class B 6	616..658		34/41 (83%)
		Ldl_recept_b	616..655	CDD:278487	31/38 (82%)
		FXa_inhibition	671..711	CDD:291342	33/39 (85%)
		Clustered O-linked oligosaccharides	721..768		22/65 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755		7/39 (18%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860		42/48 (88%)
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828		4/4 (100%)
Ldlr	NP_786938.2	Ldl_recept_a	25..58	CDD:395011	24/32 (75%)
		Ldl_recept_a	66..104	CDD:395011	28/37 (76%)
		Ldl_recept_a	107..143	CDD:395011	31/35 (89%)
		Ldl_recept_a	196..232	CDD:395011	27/35 (77%)
		Ldl_recept_a	235..271	CDD:395011	30/35 (86%)
		Ldl_recept_a	279..309	CDD:395011	27/29 (93%)
		FXa_inhibition	319..353	CDD:405372	26/33 (79%)
		EGF_CA	355..389	CDD:214542	25/33 (76%)
		LDL-receptor class B 1	398..439		36/40 (90%)
		NHL	<435..628	CDD:302697	163/194 (84%)
		NHL repeat	435..469	CDD:271320	23/35 (66%)
		LDL-receptor class B 2	440..485		31/46 (67%)
		NHL repeat	476..514	CDD:271320	33/37 (89%)
		LDL-receptor class B 3	486..528		35/41 (85%)
		LDL-receptor class B 4	529..572		41/42 (98%)
		Ldl_recept_b	529..569	CDD:395012	38/39 (97%)
		NHL repeat	555..600	CDD:271320	41/44 (93%)
		LDL-receptor class B 5	573..615		38/41 (93%)
		NHL repeat	606..628	CDD:271320	16/21 (76%)
		LDL-receptor class B 6	616..658		34/41 (83%)
		Ldl_recept_b	616..655	CDD:395012	31/38 (82%)
		FXa_inhibition	674..711	CDD:405372	32/36 (89%)
		Clustered O-linked oligosaccharides	717..788		22/70 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..797		27/78 (35%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	830..879		42/48 (88%)
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	842..847		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83679795
Domainoid	1	1.000	169	1.000	Domainoid score	I28892
eggNOG	1	0.900	-	-		E1_KOG1215
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55469
Inparanoid	1	1.050	1423	1.000	Inparanoid score	I3033
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D17642at314146
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		oto143729
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270