DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LDLR and LpR1

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	331/847 - (39%)
Similarity:	481/847 - (56%)	Gaps:	56/847 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCD 90
            |..|||:||. .:||...|:||||.:|:|.|||:.  |.:.||...:::|.....:|:|..|.||
  Fly   219 CPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAH--CRARTCSPDEYACKSGEGQCVPLAWMCD 281

Human    91 GQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTC-GPASFQ 154
            ...||.:||||..| .:||..|||.|.:|:||.:::.||.|.||.|||||..|||:.| ..|...
  Fly   282 QSKDCSDGSDEHNC-NQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHT 345

Human   155 CNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG-ECIHSSWRCDG 218
            |.:..||.:.|.||.||||.|||||  :.|..:   ...::||.:.|:.|... .|:|.||.|||
  Fly   346 CTNGACIAKRWVCDGDPDCSDGSDE--RSCANV---TKTTTPCLSHEYQCKDRITCLHHSWLCDG 405

Human   219 GPDCKDKSDEE--NCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC-------VNVT 274
            ..||.|..||.  ||...|||.|:|||.|.:||.|...|:.:.||.|.|||..|       :|..
  Fly   406 DRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQG 470

Human   275 LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECL 339
            .|...::|.|..|:|:.|.|||:..:||.|..|||..:||.|||...||||.|.|.|||:|:.|.
  Fly   471 GCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCE 535

Human   340 CPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDP--HTKACKAVGSIAYL 401
            |.:|::|...:| |:||:||:.|..|||:|||..||:||:||.|:..||  ||: |||....|.|
  Fly   536 CHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTR-CKASEGHASL 599

Human   402 FFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD 466
            ....||::||:.||..|.||::.:.:...|||....:..|:|||::.:.|....:|..   :...
  Fly   600 LLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEG---NEKT 661

Human   467 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFM 531
            .|:::.....||||||||::::|:||:...|:.:.:.:|...|.|.:::...||:|.:||:.|:|
  Fly   662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726

Human   532 YWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
            ||:|||...:|::.|::|....::::.:::|||||||||:..|:||||.||:.|||.:.:|..|.
  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791

Human   597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVN-LLAENLLS-PEDMVLFHNLT 659
            .:|...:.|.||||:..|||.|:|||...:|:|.||:.||.||. :.|.::|. |..:.::|...
  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYR 856

Human   660 QPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC---------LTEA 715
            ||.|||.|:..   ||.|.:||||||:||..||:.:||||.|:.|..|...|         :|..
  Fly   857 QPDGVNHCQSV---NGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRP 918

Human   716 EAAVATQETSTVRLKVSSTAVRTQHTTTR-PVPDTSRLPGATPGLTTVEIV----TMSHQALGDV 775
            ..|..|:.......:...|.|:..|...| .:.|..:|....|.|.|..:.    ..:|..: :.
  Fly   919 PRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQI-EK 982

Human   776 AGRGNEKKPSSVRALSIV-----LPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDE 835
            ....:|:..|...||.::     ..::|.|.|.:|    ::....:.|||:||:||:|:|||..|
  Fly   983 TTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIG----YRYCSKRRINSMNFENPIYRKTTTTE 1043

Human   836 VH 837
            .|
  Fly  1044 DH 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	16/31 (52%)
		Ldl_recept_a	66..104	CDD:278486	14/37 (38%)
		Ldl_recept_a	107..143	CDD:278486	19/35 (54%)
		Ldl_recept_a	147..179	CDD:278486	15/32 (47%)
		Ldl_recept_a	195..231	CDD:278486	16/38 (42%)
		Ldl_recept_a	235..270	CDD:278486	18/34 (53%)
		LDLa	278..308	CDD:294076	11/29 (38%)
		FXa_inhibition	318..>346	CDD:291342	14/27 (52%)
		EGF_CA	354..388	CDD:214542	20/35 (57%)
		LDL-receptor class B 1	397..438		14/40 (35%)
		LY	419..457	CDD:214531	10/37 (27%)
		LDL-receptor class B 2	439..485		14/45 (31%)
		Ldl_recept_b	439..482	CDD:278487	11/42 (26%)
		LDL-receptor class B 3	486..528		12/41 (29%)
		Ldl_recept_b	487..525	CDD:278487	10/37 (27%)
		LDL-receptor class B 4	529..572		19/42 (45%)
		Ldl_recept_b	529..569	CDD:278487	16/39 (41%)
		LY	553..595	CDD:214531	20/41 (49%)
		LDL-receptor class B 5	573..615		18/41 (44%)
		LDL-receptor class B 6	616..658		17/43 (40%)
		Ldl_recept_b	616..655	CDD:278487	16/40 (40%)
		FXa_inhibition	671..711	CDD:291342	20/39 (51%)
		Clustered O-linked oligosaccharides	721..768		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755		6/21 (29%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860		13/27 (48%)
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828		3/4 (75%)
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566
		LDLa	219..254	CDD:238060	18/36 (50%)
		LDLa	259..295	CDD:238060	13/35 (37%)
		LDLa	343..373	CDD:238060	15/31 (48%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:278486	18/35 (51%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	16/34 (47%)
		EGF_CA	551..581	CDD:214542	18/29 (62%)
		LY	662..702	CDD:214531	14/39 (36%)
		LY	704..747	CDD:214531	17/42 (40%)
		LY	749..790	CDD:214531	20/40 (50%)
		FXa_inhibition	864..905	CDD:291342	21/43 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	713	1.000	Inparanoid score	I644
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm8553
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.010