DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LDLR and T13C2.6

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_872023.2	Gene:	T13C2.6 / 174116	WormBaseID:	WBGene00020481	Length:	911	Species:	Caenorhabditis elegans

Alignment Length:	976	Identity:	302/976 - (30%)
Similarity:	444/976 - (45%)	Gaps:	231/976 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     8 LRWTVALLLAAAGTAVG--------DRCE-RNEFQCQDGKCISYKWVCDGSAECQDGSDESQETC 63
            |..|..||::.|..:||        .:|: .|.||||||:||...|.|||..:||  ::|.::.|
Worm     5 LTLTGFLLISMATISVGLQPMGAPTRKCDATNSFQCQDGRCIPMSWRCDGDIDCQ--NEEDEKNC 67

Human    64 -LSVTCKSGDFSCG----GRVN----RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD- 118
             :|..|.:.:..||    .|.:    :|||..|.|||:.||::.|||..|...:|.:.:|:|.:
Worm    68 PISEVCGAEEHKCGEVKSARSSLERFKCIPNKWVCDGEFDCEDKSDEFQCKNVSCQEKQFQCEEL 132

Human   119 ----GKCISRQFVCDSDRDCLDGSDEASCPVLT--CGPASFQCNSSTCIPQLWACDNDPDCEDGS 177
                ..||...:|||..|||.:|.||.:|...|  |...:|||::..||.:.|.||.:.||.|||
Worm   133 SGDYSLCIPETWVCDGQRDCTNGKDEQNCTSKTSKCPDNNFQCSNGNCIFKNWVCDGEEDCSDGS 197

Human   178 DEW---PQRCRGLYVFQGDSSPCSAFE-FHCLSGECIHSSWRCDGGPDCKDKSDEENCAVA--TC 236
            ||.   |..|....      :.|...| :.|.|||||.|.||||...||||.|||:||...  ||
Worm   198 DELLTAPSNCNRTV------NQCPPGEMWKCGSGECIPSRWRCDAEVDCKDHSDEKNCTAIQHTC 256

Human   237 R-PDEFQC-SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGE----------- 288
            : .:||.| :..|||:.:..||.|.||.|.|||..|.:|       :.:|.|||
Worm   257 KLAEEFACKASHNCINKAFVCDGELDCSDGSDEDDCADV-------RTECKSGERTCPASYGAYG 314

Human   289 -------CITLDKVCNMARDCRDWSDEPIKEC----------GTN-EC----------------- 318
                   ||.....||...||.|..||  |||          ||. ||
Worm   315 AESGHVVCIPASSWCNGEEDCPDGGDE--KECNMTAPVTCQKGTEYECPSTPLQCIEMSKLCASA 377

Human   319 -LDNNGGCSHVCNDLKI--------------------GYECLCPDGFQLVAQRRCEDIDECQDPD 362
             .|...|...||:..||                    ...|.|.||::| ...:|.||:||:...
Worm   378 QFDCGDGNMSVCSQKKIIEMCKPSSEGCVCRPSFVRGNNVCHCKDGYKL-ENGQCIDINECEIAG 441

Human   363 TCSQLCVNLEGGYKCQCEEGFQLD-PHTK--------ACKAVGSIAYLFFTNRHEVRKMTLDRSE 418
            .|.|:|:|:.|.|:|.|..|:|:. ..||        .|:|:|....:..||||.:|:..|....
Worm   442 VCDQICLNIPGSYRCACHAGYQISFGDTKIGSGRIANKCRAMGGDPLVLLTNRHTIRQFDLVNKM 506

Human   419 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMI--CS-----------TQLDRAHGVSSYDTVIS 470
            :..:..:..:.||:|..:.:..:.|||:..:.|  ||           ...|:.|     :.|::
Worm   507 HFPVSSSPGSAVAMDFHILNGTLIWSDVLSKQILKCSIGNVSNAFLGTDMCDKKH-----EIVLT 566

Human   471 RD-IQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT 534
            .| |..||||||||:|..::|||..|..::|.|.|..|::.|:..:..:||||.|||..|.::||
Worm   567 GDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLDMKNGKQRVLYSSDLEEPRAIAVDPEVGLIFWT 631

Human   535 DWGTPAKIKKGGLNGVDIYSLVT-ENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTI 598
            |||..|:|::.|::|.....:|. :.:.||||:.||.:..|:||.|:|:.||.|.|..|.|.||:
Worm   632 DWGKKARIERSGMDGQHRTVIVEGDRVVWPNGLALDYVDKRVYWADAKIKSIFSCDYWGKNIKTV 696

Human   599 LEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRG 663
            |...:.|.||||:|||||::|:||..::.:.:.|:.||:|:..:.:.:.||..:.::|...||..
Worm   697 LHSHQYLRHPFSMAVFEDRLFYTDWEHDGVITVNKFTGADIRTVMDQVKSPMTVRIYHKQAQPLM 761

Human   664 VNWCERTTLSNGGCQYLCLPAPQINP---------HSPKFTCACPDGMLLARDMRSCLTEAEAAV 719
            .|.||     |..|.:||||......         |...|:||| :| ..|.|:..|..:.|.
Worm   762 QNKCE-----NSECDHLCLPRAVYREKERVHEKTWHDRPFSCAC-EG-TTASDVLECFADLET-- 817

Human   720 ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKP 784
                                                                            .
Worm   818 ----------------------------------------------------------------K 818

Human   785 SSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHN--QDGYSY 847
            |.:...:|.|.:.:...:..|..::.:....:...::|||||:|::|||:..|...:  :|.::.
Worm   819 SGISMFTIFLLLCVGGVVAAGFVIVRRKMGPRTFTALNFDNPIYRRTTEEADHQMEDPFRDPFAE 883

Human   848 P 848
            |
Worm   884 P 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	16/33 (48%)
		Ldl_recept_a	66..104	CDD:278486	16/45 (36%)
		Ldl_recept_a	107..143	CDD:278486	14/40 (35%)
		Ldl_recept_a	147..179	CDD:278486	15/33 (45%)
		Ldl_recept_a	195..231	CDD:278486	20/36 (56%)
		Ldl_recept_a	235..270	CDD:278486	17/36 (47%)
		LDLa	278..308	CDD:294076	11/47 (23%)
		FXa_inhibition	318..>346	CDD:291342	11/65 (17%)
		EGF_CA	354..388	CDD:214542	14/34 (41%)
		LDL-receptor class B 1	397..438		9/40 (23%)
		LY	419..457	CDD:214531	9/50 (18%)
		LDL-receptor class B 2	439..485		19/59 (32%)
		Ldl_recept_b	439..482	CDD:278487	16/56 (29%)
		LDL-receptor class B 3	486..528		16/41 (39%)
		Ldl_recept_b	487..525	CDD:278487	13/37 (35%)
		LDL-receptor class B 4	529..572		17/43 (40%)
		Ldl_recept_b	529..569	CDD:278487	15/40 (38%)
		LY	553..595	CDD:214531	17/42 (40%)
		LDL-receptor class B 5	573..615		21/41 (51%)
		LDL-receptor class B 6	616..658		11/41 (27%)
		Ldl_recept_b	616..655	CDD:278487	10/38 (26%)
		FXa_inhibition	671..711	CDD:291342	14/48 (29%)
		Clustered O-linked oligosaccharides	721..768		0/46 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755		0/20 (0%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860		12/40 (30%)
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828		4/4 (100%)
T13C2.6	NP_872023.2	LDLa	36..67	CDD:238060	16/32 (50%)
		LDLa	73..117	CDD:238060	16/43 (37%)
		LDLa	122..161	CDD:238060	14/38 (37%)
		LDLa	167..199	CDD:197566	14/31 (45%)
		LDLa	214..249	CDD:238060	20/34 (59%)
		LDLa	261..292	CDD:238060	15/30 (50%)
		LDLa	<322..344	CDD:238060	10/23 (43%)
		EGF_CA	433..463	CDD:214542	13/29 (45%)
		LY	564..606	CDD:214531	20/41 (49%)
		LY	606..649	CDD:214531	18/42 (43%)
		LY	649..692	CDD:214531	17/42 (40%)
		LY	696..736	CDD:214531	17/39 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I8690
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I788
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010