DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syx13 and Stx17

DIOPT Version :9

Sequence 1:	NP_001261794.1	Gene:	Syx13 / 39485	FlyBaseID:	FBgn0036341	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_080619.2	Gene:	Stx17 / 67727	MGIID:	1914977	Length:	301	Species:	Mus musculus

Alignment Length:	243	Identity:	61/243 - (25%)
Similarity:	107/243 - (44%)	Gaps:	36/243 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AIHSSTK-----QLEKQLK-LIGTSKEQP-NLREKVHTINTKCNARVQTTSQDLQRLQAVVRHGD 117
            ||...||     .||:..| .|...|.|. .:.:|:|..:......||....:::.::.:.....
Mouse    16 AIQKFTKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVH 80

  Fly   118 RQQKLQLEKL-----------TREF---HGVVEKYSNLQRRISSAMRQTLQQA---QQFADQVVE 165
            :...:.|:::           |.||   |  :|....|:::::.  .:.||.:   ....|.|:.
Mouse    81 KDDLVLLKRMIDPVKEAAATATAEFLQLH--LESVEELKKQVND--EELLQPSLTRSTTVDGVLH 141

  Fly   166 TNARAELLQQQRLEQAHLQQEHDMLDDRRRQVEQIESDIIDVNQIMTQLSGLVHDQGQQMDFIEN 230
            | ..||...|. |.|.:...|.....:.....|.:|:|:|:::.::|.:|.||..|.:::|.|.:
Mouse   142 T-GEAEAASQS-LTQIYALPEIPQDQNAAESWETLEADLIELSHLVTDMSLLVSSQQEKIDSIAD 204

  Fly   231 SIEQTAANVEDGTSELAKAARSRQSYRRKILILLVIAVIIGLIVTGVI 278
            .:...|.|||:||..|.|||      :.|:..|.|...:||.:|.|.|
Mouse   205 HVNSAAVNVEEGTKNLQKAA------KYKLAALPVAGALIGGVVGGPI 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx13	NP_001261794.1	Syntaxin_2	54..153	CDD:291208	21/113 (19%)
Syx13	NP_001261794.1	SNARE_syntaxin7_like	190..249	CDD:277200	18/58 (31%)
Stx17	NP_080619.2	SNARE_syntaxin17	161..222	CDD:277199	18/60 (30%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		7/19 (37%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810