DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx13 and TSNARE1

DIOPT Version :9

Sequence 1:	NP_001261794.1	Gene:	Syx13 / 39485	FlyBaseID:	FBgn0036341	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_011515216.1	Gene:	TSNARE1 / 203062	HGNCID:	26437	Length:	838	Species:	Homo sapiens

Alignment Length:	306	Identity:	78/306 - (25%)
Similarity:	136/306 - (44%)	Gaps:	55/306 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKALNNPGGNGGGGGPHRDYGAMADSTPEVSFAA------AGGSSGFS----------PTEFMS 49
            :.||.:.|  :.|.|.|.    |:| .||.....|      |..|.|||          |.....
Human   229 LRKAAHGP--SPGSGKPQ----ALA-LTPVEQVVAKTFSCQALPSEGFSLEPPRATQVDPCNLQE 286

  Fly    50 LSEDIGHNITAIHSSTKQLEKQLKLIGTSKEQPNLREKVHTINTKCNARVQTTSQDLQRLQAVVR 114
            |.:::..|:..|:||...||:.|:.:||..:...||:.:||...:.|..:..::..::::..::|
Human   287 LFQEMSANVFRINSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLR 351

  Fly   115 HGDRQQKL-----QLEKLTREFHGVVEKYSNLQRRISSAMRQTLQQAQQFADQVVETNARAELLQ 174
            ....|::|     ||::|..:....::.|..:|::|:...|..|..||:.:.|.......|||..
Human   352 SSCPQERLQQERPQLDRLKTQLSDAIQCYGVVQKKIAEKSRALLPMAQRGSKQQSPQAPFAELAD 416

  Fly   175 QQRL-----------EQAHLQQ--EHDMLDDRRRQ--VEQIESDIIDVNQIMTQLSGLVHDQGQQ 224
            .:::           |||.|..  |.|:...|.|:  :.|:||:::|||||:..|:.:|.:||:.
Human   417 DEKVFNGSDNMWQGQEQALLPDITEEDLEAIRLREEAILQMESNLLDVNQIIKDLASMVSEQGEA 481

  Fly   225 MDFIEN--------SIEQTAA----NVEDGTSELAKAARSRQSYRR 258
            :....:        |.|..||    ....|::.|.....||...|:
Human   482 VGSSSSKAICQQSCSPEPAAAALLLGAGPGSTPLRPGPHSRTKTRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx13	NP_001261794.1	Syntaxin_2	54..153	CDD:291208	24/103 (23%)
Syx13	NP_001261794.1	SNARE_syntaxin7_like	190..249	CDD:277200	20/72 (28%)
TSNARE1	XP_011515216.1	Myb_DNA-bind_5	151..225	CDD:290584
		Syntaxin_2	292..393	CDD:291208	23/100 (23%)
		SNARE	444..>484	CDD:304603	14/39 (36%)
		Myb_DNA-bind_5	526..598	CDD:290584	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151503
Domainoid	1	1.000	49	1.000	Domainoid score	I11831
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77339
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000747
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840