DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx13 and Stx12

DIOPT Version :9

Sequence 1:	NP_001261794.1	Gene:	Syx13 / 39485	FlyBaseID:	FBgn0036341	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_598648.1	Gene:	Stx12 / 100226	MGIID:	1931027	Length:	274	Species:	Mus musculus

Alignment Length:	260	Identity:	77/260 - (29%)
Similarity:	144/260 - (55%)	Gaps:	17/260 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GSSGFSPTEFMSLSEDIGHNITAIHSSTKQLEKQLKLIGTSKEQPNLREKVHTINTKCNARVQTT 102
            |.||..|.:|.|:.:....||..|..:|.|::..:..:||.::...|:|.:..:....|...:.|
Mouse    13 GPSGPQPRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKET 77

  Fly   103 SQDLQRLQA----VVRHGDRQQKLQLEKLTREFHGVVEKYSNLQRRISSAMRQTLQQA------- 156
            ::.|:.|.:    :.....||||||.|:|..:|...:..:..:||::|...::::.:|
Mouse    78 NELLKELGSLPLPLSASEQRQQKLQKERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLS 142

  Fly   157 ---QQFADQVVETNARAE--LLQQQRLEQAHLQQEHDMLDDRRRQVEQIESDIIDVNQIMTQLSG 216
               :|..:|:|..::..|  .:|.|..|.|..:|:.:::.:|...:.|:|:||:|||||...|:.
Mouse   143 AEDRQREEQLVSFDSHEEWNQMQSQEEEAAITEQDLELIKERETAIRQLEADILDVNQIFKDLAM 207

  Fly   217 LVHDQGQQMDFIENSIEQTAANVEDGTSELAKAARSRQSYRRKILIL-LVIAVIIGLIVTGVIVA 280
            ::||||..:|.||.::|.:..:||..|.:|.:||..::..|:|:.|| ||::||:.::|..:.||
Mouse   208 MIHDQGDLIDSIEANVESSEVHVERATDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVA 272

Fly 281 280
Mouse 273 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx13	NP_001261794.1	Syntaxin_2	54..153	CDD:291208	25/102 (25%)
Syx13	NP_001261794.1	SNARE_syntaxin7_like	190..249	CDD:277200	23/58 (40%)
Stx12	NP_598648.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/6 (50%)
		SynN	21..164	CDD:238105	32/142 (23%)
		Syntaxin	26..213	CDD:279182	48/186 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..147		1/18 (6%)
		SNARE_syntaxin12	181..247	CDD:277229	25/65 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53539
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000747
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820