DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srrm1 and srrm1

DIOPT Version :9

Sequence 1:	NP_648627.1	Gene:	Srrm1 / 39483	FlyBaseID:	FBgn0036340	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001352210.1	Gene:	srrm1 / 406751	ZFINID:	ZDB-GENE-040426-2789	Length:	929	Species:	Danio rerio

Alignment Length:	1022	Identity:	334/1022 - (32%)
Similarity:	478/1022 - (46%)	Gaps:	179/1022 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEF 67
            |.||:.:||.|||:|.|||:||:||.:||.|:|||:||.|:|::|||::::|:||..|||||:||
Zfish     6 FRGTSAEQDNRFSNKHKKLLKQLKFAECLEKKVDMTKVNLEVIKPWITQRVTEILGFEDDVVIEF 70

  Fly    68 VYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEI--- 129
            |:||| |||.|..|.||||:||||||:|||:||.:||.|||||||:.:|||:.|::|||:||
Zfish    71 VFNQL-EEKNPDGKMMQINLTGFLNGKNAREFMKDLWPLLLSAQENIAGIPSAFLEQKKEEIKQR 134

  Fly   130 ---------LKREEEQRQRDRSRSRSRSRS-QRDSSRRDRQRDRSKSKSRSRS--RSMKPANNNG 182
                     ||:.:|.::...::.|::|:| :|..||...:|||..|.|||||  |.:.||.:..
Zfish   135 QIEQEKLASLKKVDEDKREKENKERAQSKSPKRRKSRSPVKRDRKSSPSRSRSPRRKISPAASPP 199

  Fly   183 SVPSAAREAAANAAAKIRKRGSSSAARP--------GSRERRSSRRPRSRSRSRSRTAGKKTGSV 239
            |.|...:|...      |:...|.:::|        .:.:..:..:|.|.|.....::..||...
Zfish   200 SSPPNHKEEPK------REPDQSESSKPEPLIQEASSTSDLVTEMKPDSVSEPVKESSPDKTSKS 258

  Fly   240 EPAPA---KTVNGRHSTDKSSPVPPASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSRRSRR 301
            |..|.   :..:||               |.|.|..|||||||||.|..|  ||||.|..||:..
Zfish   259 EDRPKPRDREKDGR---------------KDRPRHRSRSRSPRSRRRPRS--RSRSFSPRRRTSP 306

  Fly   302 RGRSSSISLSPERNQDQFEHRRNKNSVQNKRQYRNNRGDSASSMERG-NDRGRQFGGGGGGRRGG 365
            |.|.|....||.|.|....|||:::.|:.:|.  .:|..|.||..|. :.|..:.|.....|:..
Zfish   307 RRRISPRRRSPPRRQPPSRHRRSRSPVRRRRS--RSRSSSGSSSSRSPHKRAGKRGSATPPRKLA 369

  Fly   366 RR---FSP---RGRSPMRQDNG--------GGNGGNRFQRSNSRRR----SRSRRLSRSPMRYSR 412
            ||   .||   |||||...|..        ||...:|......||.    |...:|.:.....|.
Zfish   370 RRTDLSSPPRRRGRSPSGPDTSPSAGKHRPGGRNDSRSPSPKPRRSDASDSEEDKLGKGSTADSV 434

  Fly   413 SPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRG-GSPNFRGGGRIHWQARHSPGGGGRGGG 476
            ..|| ..||::...:...|........|.|:  |:|| |:.|    |.|..:..|||....|...
Zfish   435 QQRR-QYRRQNQQSSSDTGSSSSSEDEGPRR--QNRGAGARN----GEIRRRRSHSPASPRRRHR 492

  Fly   477 GGMGRFDRRQSPQQNRYNRDHR-QSPMQQNQ-----PFRKQFSPHQGPGRRFSSPQQRRNSRDRR 535
            ....|..|..||.    .|.|| |||:::.:     |.|:..||   |.|||:.|.|||.|....
Zfish   493 DASPRKRRSPSPP----GRRHRSQSPVRRRRSPSPPPRRRSPSP---PPRRFTPPIQRRYSPPSP 550

  Fly   536 PNSRERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGRQQRQRSASPPEKRRSSHS------R 594
            ..:::||||    |....|..:|.|...||......    .:|:.|.|||.|||.|.|      .
Zfish   551 SPAQKRRSS----GSPPKRRRSPSPMPKRRIPPSPP----PKRRMSPSPPPKRRKSPSPMSKRRT 607

  Fly   595 SRSLSRNRSRSRSSSQHSRKRESPIGRSSVEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAV 659
            |.|:|:.|:.....::| |:..||:.:... .|.|.          .:|:|.|      ...|..
Zfish   608 SPSVSKRRTSPSPVAKH-RRSPSPMSKRRT-CASPV----------SKRRNSP------SPAPQR 654

  Fly   660 RSSYASLSR---TPSPFLKPHERLAAAKAAAAASAAVPKKSRDQS--QSSSSDSSAESDDSEEQP 719
            |||.:.:.:   :|||..|.|            ::..||:||..|  :..:..|||     ...|
Zfish   655 RSSPSPMPKHRGSPSPVTKRH------------TSRSPKRSRGTSPGKRRTPPSSA-----SPPP 702

  Fly   720 R-RKKQPTNMETSKGKKEKVRRSSESSTSSEQSDDEDNSSGDERLKKKLQQRKSKEAAALKGKEK 783
            | |:..|......:|:..:....:.::..|........:||....:::.|...|.....::...:
Zfish   703 RHRRNSPNPPAAQRGRDTRSSPPAHTTRVSSSPPGRYGASGSSPQRQRRQTSPSHSTRPIRRVSR 767

  Fly   784 EHEKEKDKRRSDKKSKRGAISSGDEESTSSRKRG-----HKKTRRDEAGDNSDSEDEHVPKKKRK 843
            ..|        .:||:||:.|...|....||...     .:|.....:...|.|.....|.||..
Zfish   768 TPE--------PRKSQRGSQSPPPERRQVSRSPSASPPPAQKRPASVSPSRSTSRSPPPPAKKNS 824

  Fly   844 K-AKKPADSSDSDSEASSKRKKHKKHKKHSKKSKKHKKHK--RKCSAGKSRADSSSQGSSDEDEQ 905
            . :..|:.:.:||:|...|:|| ||.||| ||.|||||||  :|...|:.::..::.|...|.|
Zfish   825 SVSPSPSPNKNSDAEGGKKKKK-KKEKKH-KKDKKHKKHKKQKKEKGGEEKSGGATGGHGPEAE- 886

  Fly   906 LPHSVAAKRNGNAGKLALLLPGASGAGVINEDLEKQLRERALKSMKK 952
             |.|...|.:.:..:.:|            :||||.|||:||:||:|
Zfish   887 -PDSDQKKESESEVEDSL------------DDLEKHLREKALRSMRK 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srrm1	NP_648627.1	PWI	43..113	CDD:279781	46/69 (67%)
srrm1	NP_001352210.1	PWI	46..115	CDD:307570	46/69 (67%)
srrm1	NP_001352210.1	Herpes_ICP4_C	469..>786	CDD:332854	98/378 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6921
eggNOG	1	0.900	-	-		E1_KOG2146
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2217
OMA	1	1.010	-	-		QHG46603
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005511
OrthoInspector	1	1.000	-	-		oto39000
orthoMCL	1	0.900	-	-		OOG6_103077
Panther	1	1.100	-	-	LDO	PTHR23148
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960