DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdenoK and ADO1

DIOPT Version :9

Sequence 1:	NP_001287054.1	Gene:	AdenoK / 39479	FlyBaseID:	FBgn0036337	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_012639.1	Gene:	ADO1 / 853569	SGDID:	S000003866	Length:	340	Species:	Saccharomyces cerevisiae

Alignment Length:	337	Identity:	137/337 - (40%)
Similarity:	202/337 - (59%)	Gaps:	13/337 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVGCGNPLLDISAVVPLNFLQKYSMNEDDAILAE----DRHMPIYGELVEGYQAEFLAGGSVQNS 70
            ||..||||||..|.|...:|.|||:.|:||||.:    |..|.|:.||::..:.:.:|||:.||:
Yeast     5 LVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDAKMAIFDELLQMPETKLVAGGAAQNT 69

  Fly    71 LRIAQWILRQPRVAVFFGCVGEDRYANILKEKAQAAGLDVHYQVKKDVPTGTCAVLITGTHRSLC 135
            .|.|.::|...:| |:||.||:|:::..|..:.:.||:...|||:.|:.||.||.||||.:|||.
Yeast    70 ARGAAYVLGAGQV-VYFGSVGKDKFSERLLNENEKAGVKSMYQVQNDIGTGKCAALITGHNRSLV 133

  Fly   136 ANLAAANNFTIDHLEEPSNKALVDNAQYYYISGFFLTVNPPSIMQVAATAHAKQRPFLMNLSAPF 200
            .:|.|||.||.|||::  :..||:.|:.:||.||.|||:|.:|:::...|....:||::|.||||
Yeast   134 TDLGAANFFTPDHLDK--HWDLVEAAKLFYIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPF 196

  Fly   201 ISQFYMAPLLAALPYVDIIFGNEAEAQAFAEAQQ--WPSGDLREIGKRLVAMEKKNPTRPRIAIL 263
            |...:...|...|||..:|..||:||:||.:|.|  ..:.||..|.:|:|   |.:|.. :..|.
Yeast   197 IPHVFKDALARVLPYATVIIANESEAEAFCDAFQLDCANTDLEAIAQRIV---KDSPVE-KTVIF 257

  Fly   264 TQGCDPVLLIQQDSVQEFPVTKLAVHEIVDTNGAGDAFVGGFLSQFVQGKSLDVCIRCGNYAAGH 328
            |.|.:|.:::.......:||..|...:|||||||||||.|||::...:|:.|:..|..|.:.|..
Yeast   258 THGVEPTVVVSSKGTSTYPVKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAAL 322

  Fly   329 IIKNPGCTYSGE 340
            .|:..|.:|..|
Yeast   323 SIQEVGPSYPSE 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdenoK	NP_001287054.1	PTZ00247	10..343	CDD:240328	137/337 (41%)
AdenoK	NP_001287054.1	ribokinase_pfkB_like	14..343	CDD:294126	135/333 (41%)
ADO1	NP_012639.1	adenosine_kinase	5..332	CDD:238573	135/333 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344142
Domainoid	1	1.000	208	1.000	Domainoid score	I517
eggNOG	1	0.900	-	-		E1_COG0524
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I702
Isobase	1	0.950	-	0	Normalized mean entropy	S836
OMA	1	1.010	-	-		QHG53733
OrthoFinder	1	1.000	-	-		FOG0003751
OrthoInspector	1	1.000	-	-		otm46803
orthoMCL	1	0.900	-	-		OOG6_100649
Panther	1	1.100	-	-	O	PTHR45769
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R25
SonicParanoid	1	1.000	-	-		X2162
TreeFam	1	0.960	-	-
	15	14.740