Protein Alignment Icmt and ICMT

DIOPT Version :10

• Sequence 1: NP_648623.1
• Gene: Icmt / 39478
• FlyBaseID: FBgn0036336
• Length: 299
• Species: Drosophila melanogaster
• Sequence 2: NP_036537.1
• Gene: ICMT / 23463
• HGNCID: 5350
• Length: 284
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 145/299 - (48%)
• Similarity: 196/299 - (65%)
• Gaps: 20/299 - (6%)

  Fly     2 CAKSRVASPGAGGTSLCSEGRISLYCFLITAALVLIPSVPQ-NLYGVVPQVWGAVLWGPFLYYAL 65
            ||..  |.||       ||.|:||..||:.|:::.:|.:.: .|.|..         |..||.|.
Human     4 CAAR--APPG-------SEARLSLATFLLGASVLALPLLTRAGLQGRT---------GLALYVAG 50

  Fly    66 INMIIRFVLRNHDYQVAIRASFLGFAMAVSVLVICFAPTEWQQFGAYGCFMSLFHYSEFLVIAFA 130
            :|.::..:.|...||:||||.||||......| :.|:.:.|..||.|.|.:|||||||:||.|..
Human    51 LNALLLLLYRPPRYQIAIRACFLGFVFGCGTL-LSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVN 114

  Fly   131 NPRTLSLDSFMLNHSVHYGLAAAASWIEFSLEVYYLPQFKRYGYIWVAGVVLCLLGEMVRKAAII 195
            ||::||||||:||||:.|.:||.:||:||:||..:.|:.|:..::.|.|:::.:.||.:||||:.
Human   115 NPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMF 179

  Fly   196 TAGRSFTHLVQNEKHSEHKLITSGIYAYCRHPSYVGWFWWSIGTQIVLLNPICICIYTLVSWLFF 260
            |||.:|.|:|||||...|.|:|||:||:.|||||||||:||||||::|.||||...|.|..|.||
Human   180 TAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFF 244

  Fly   261 HDRIYVEEYSLLNFFQSDYVRYQKRVPTGLPFIRGYLVD 299
            .||...||.||::||..:|:.|:||||||||||:|..||
Human   245 RDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVD 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Icmt	NP_648623.1	ICMT	179..271	CDD:427740	53/91 (58%)
ICMT	NP_036537.1	ICMT	163..257	CDD:427740	55/93 (59%)