DRSC/TRiP Functional Genomics Resources

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Protein Alignment MICAL-like and ACTN3

DIOPT Version :10

Sequence 1:NP_648621.1 Gene:MICAL-like / 39475 FlyBaseID:FBgn0036333 Length:1010 Species:Drosophila melanogaster
Sequence 2:NP_001245300.2 Gene:ACTN3 / 89 HGNCID:165 Length:944 Species:Homo sapiens


Alignment Length:531 Identity:124/531 - (23%)
Similarity:191/531 - (35%) Gaps:156/531 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            :.|..||:..|..|..|.|:|..|||::|||.||:||..||||||:.:|:.||...|.:.||..|
Human   205 EGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVA 269

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLG-------------KSLKHPKPEEPLGE 130
            ||||.||.:|||.|:|:...||..:|:||:|.||....             |.|...:..|.|.|
Human   270 EKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLME 334

  Fly   131 ESEPPQKVM------------HIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSL 183
            |.|.....:            :.||.|.....|          |.|...|.|.|          |
Human   335 EYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ----------RKLEDFRDYRR----------L 379

  Fly   184 LTPGSFYE---TEVNNIYCCETCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEA----E 241
            ..|....|   .|:|    ..|...:        |:|.......|::.::|   ||.:.|    |
Human   380 HKPPRIQEKCQLEIN----FNTLQTK--------LRLSHRPAFMPSEGKLV---SDIANAWRGLE 429

  Fly   242 DKQEDLED---NDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEERKISFIPLDEEDGGLIE 303
            ..::..||   ::||...:.::......:....:|........:||:.         :.|..|::
Human   430 QVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQR---------DYDSALLQ 485

  Fly   304 QYNKSTTPVKPAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPE------------NDIP-KEKLK 355
            :       |:..:             .:|...|  :|||...:            |::. .|...
Human   486 E-------VRALL-------------RRHEAFE--SDLAAHQDRVEHIAALAQELNELDYHEAAS 528

  Fly   356 ISS--VSIYLEDDRL-VVDAIHPDNLDKQEALNNTSDALIPESQEAPIPENN------------- 404
            ::|  .:|..:.|.| .:.....|.|::.|.|..|.|.|..|......|.||             
Human   529 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVW 593

  Fly   405 -------TQVAIKPEDHISPRKENKIFSNTESCSKQEGVLPKQMDLESPKDKVIET----KASET 458
                   ||..:...|...        :......::.|.:   |.::....|:.:|    ..|..
Human   594 LVHSVEETQSLLTAHDQFK--------ATLPEADRERGAI---MGIQGEIQKICQTYGLRPCSTN 647

  Fly   459 DY----PEDLN 465
            .|    |:|:|
Human   648 PYITLSPQDIN 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MICAL-likeNP_648621.1 CH_MICALL2 11..115 CDD:409102 50/100 (50%)
LIM_like_1 146..207 CDD:188784 12/63 (19%)
PTZ00449 <411..727 CDD:185628 10/63 (16%)
bMERB_dom 785..933 CDD:463467
ACTN3NP_001245300.2 CH_ACTN_rpt1 92..189 CDD:409063
CH_ACTN_rpt2 193..307 CDD:409065 50/101 (50%)
Spectrin 331..440 CDD:395348 29/143 (20%)
SPEC 452..679 CDD:238103 40/249 (16%)
SPEC 570..790 CDD:238103 16/100 (16%)
PTZ00184 797..>901 CDD:185504
EFhand_Ca_insen 874..940 CDD:430177
Blue background indicates that the domain is not in the aligned region.

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