Protein Alignment MICAL-like and CLMN

DIOPT Version :10

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_011535460.1
• Gene: CLMN / 79789
• HGNCID: 19972
• Length: 1033
• Species: Homo sapiens
• Alignment Length: 954
• Identity: 198/954 - (20%)
• Similarity: 324/954 - (33%)
• Gaps: 307/954 - (32%)

  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            |||..|.:..|:.| ||.|::...|||:||||.|:|....|.|:|..:...:...||.:.||:.|
Human   191 KALLAWVQRKTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIA 254

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLGKSLKHPKPEEPLGEESEPPQKVMHIVG 143
            :..|.||.||:..| :..:.||..||:||::||
Human   255 QDALHIPRLLEPED-IMVDTPDEQSIMTYVAQF-------------------------------- 286

  Fly   144 MPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPDEES 208
                            .||                          |.|.|..:|:    ..|:|.
Human   287 ----------------LER--------------------------FPELEAEDIF----DSDKEV 305

  Fly   209 EPESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQEDLEDNDIRT-TDKPENFQPP------SN 266
            ..||..:::|.|.                ||.|.|...|.:|..|| |...|...||      .:
Human   306 PIESTFVRIKETP----------------SEQESKVFVLTENGERTYTVNHETSHPPPSKVFVCD 354

  Fly   267 KDEQNNELTINPVNPILSEERKISFIP--LDEEDGGLIEQYNKSTTPVKPAIPEKPKVS------ 323
            |.|...|..::.|:.....:....|:.  :|:    :::.....|:.:....||...:|
Human   355 KPESMKEFRLDGVSSHALSDSSTEFMHQIIDQ----VLQGGPGKTSDISEPSPESSILSSRKENG 415

  Fly   324 ---TLPLDDEQHAGVE--------QNNDLAVSPENDIPKEKLKISSVSIYLEDDRLVVDAIHPDN 377
               :||:....|...:        :|..|.......:.||.|:        :|..::...:..:.
Human   416 RSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSPRVAKESLR--------QDGHVLAVEVAEEK 472

  Fly   378 LDKQEALNNTSDALIPESQEAPI---------PENNTQVAI-----------KPEDH-ISPRKEN 421
            ..|||:      :.||||....:         ..||:|.:.           ..|.| :||..||
Human   473 EQKQES------SKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSLSPPGEN 531

  Fly   422 KIFSNTESCSKQEGVLPKQMDLESPKDKVIETKASETDYPEDLNPFKDDDSSKGANPFDSSDDEV 486
            .:.:::..      :....|.:|:         ..|.||.|.: |.|       |:.|:|
Human   532 TVMADSFQ------IKVNLMTVEA---------LEEGDYFEAI-PLK-------ASKFNS----- 568

  Fly   487 ELLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKPHSSPTLSHGKKMPMPTPRISISK----- 546
            :|:......|:..||..|....|.....:..|.:||.......|..||...|.|::.:.|
Human   569 DLIDFASTSQAFNKVPSPHETKPDEDAEAFENHAEKLGKRSIKSAHKKKDSPEPQVKMDKHEPHQ 633

  Fly   547 -------------TQTPA--KPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRGSSISLPSANGP 596
                         .:||.  ||..|:..|   ..|:..|..     :.|.||        ...|
Human   634 DSGEEAEGCPSAPEETPVDKKPEVHEKAK---RKSTRPHYE-----EEGEDD--------DLQG- 681

  Fly   597 RKPLRASVGSPLRSEESSPTTSLSSITS------------PMRK------------KRQAPLPPI 637
                   ||..|.|...|...||.::.|            |:.|            ..:.||..:
Human   682 -------VGEELSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAV 739

  Fly   638 QTDFDSDPGFSKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNAD 702
            ...:..||  ..|.:|:..|...:...|:| ||..     :::..|..::.||...|||  .:|.
Human   740 LEAYVEDP--EDLKNEEMDLEEPEGYMPDL-DSRE-----EEADGSQSSSSSSVPGESL--PSAS 794

  Fly   703 EEVNVVYRRIL--VPPTQP---------------ENTVERSKEDQKSP---IVYNDFDRNVSPLG 747
            ::|..:.|..:  .|.::|               ||....|.:.|:||   .:.|..:.||:
Human   795 DQVLYLSRGGVGTTPASEPAPLAPHEDHQQRETKENDPMDSHQSQESPNLENIANPLEENVT--- 856

  Fly   748 HNKSTHGKWKRRKGPAPAVP----IPPRKVLQRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIR 808
             .:|...|.|.::.....|.    :.|..|.....|:|...::.|  ..:.......:.|.:...
Human   857 -KESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSI--PSRTSHSDSSIYLRRHTH 918

  Fly   809 DRCE-------RSLDATDTDGPESAEVLT--NSKEVEDLILQLF 843
            ...|       :..:|.|.|...: .:||  :::::.:||||.:
Human   919 RSSESDHFSYVQLRNAADLDDRRN-RILTRYSTQKLTELILQFY 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	40/100 (40%)
		LIM_like_1	146..207	CDD:188784	7/60 (12%)
		PTZ00449	<411..727	CDD:185628	78/377 (21%)
		bMERB_dom	785..933	CDD:463467	12/68 (18%)
CLMN	XP_011535460.1	CH_CLMN_rpt1	29..142	CDD:409040
		CH_CLMN_rpt2	186..291	CDD:409094	42/175 (24%)