Protein Alignment MICAL-like and MICALL2

DIOPT Version :9

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_011513822.1
• Gene: MICALL2 / 79778
• HGNCID: 29672
• Length: 1068
• Species: Homo sapiens
• Alignment Length: 1103
• Identity: 271/1103 - (24%)
• Similarity: 428/1103 - (38%)
• Gaps: 278/1103 - (25%)

  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            :||:.|||...:||..|.:.|||||:|:|||||||:|..|||||:|..||.::|||||.|||..|
Human     5 RALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENNKLAFRVA 69

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKV------LG-----KSLKHPKPEEPLGEES 132
            |::|||||||||.|||:.:||||||||||:||:|..      :|     |.......|||.|:::
Human    70 EEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKRASEDSEEEPSGKKA 134

  Fly   133 ------------------------------------EPPQKVMHIVGMPRRDKCQKCNLPVFLAE 161
                                                .||:....:.|......|..|...|.|.:
Human   135 PVQAAKLPSPAPARKPPLSPAQTNPVVQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQ 199

  Fly   162 RVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPDEESEPESDILKLKTTTTDSPN 226
            |.|...|.|||:|.:|.:||..|..|::..|.....:.|.:             .|....:.||.
Human   200 RHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCTS-------------HLPAAASASPK 251

  Fly   227 -----DKQMVAQSSDYSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEE 286
                 .:|..|...|...:...|:..|.|..|    |..::|.:........:...| ||..:
Human   252 LTGLVPRQPGAMGVDSRTSCSPQKAQEANKAR----PSAWEPAAGNSPARASVPAAP-NPAAT-- 309

  Fly   287 RKISFIPLDEEDGGLIEQYNKSTTPV---KPAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPEND 348
                                 |.|.|   .||.|.:.:::..|.:.:....|..::.:..|....
Human   310 ---------------------SATSVHVRSPARPSESRLAPTPTEGKVRPRVTNSSPMGWSSAAP 353

  Fly   349 IPKEKLKISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPED 413
            .                  ....|.||               .:|.|  ||.|...|     |:.
Human   354 C------------------TAAAASHP---------------AVPPS--APDPRPAT-----PQG 378

  Fly   414 HISPR---KENKIFSNTESCSKQE--GVLPKQMDLESPKDKVIETKASETDYPEDLNPFKDDDSS 473
            ..:||   .:..:.|::.|.:..:  ...|.....:..::|..:|.|.         |.....|.
Human   379 GGAPRVAAPQTTLSSSSTSAATVDPPAWTPSASRTQQARNKFFQTSAV---------PPGTSLSG 434

  Fly   474 KGANPF-----DSSDDEVE--LLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKPHSSPTLSH 531
            :|..|.     |||.::..  |.:|:.|.:..|...|.||.|....:.|....:|.|.:||.
Human   435 RGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPL--- 496

  Fly   532 GKKMPMPTPRI-SISKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRGSSISLPSANG 595
            .|.:...:||: .:.....|..|         :|:||:...:::....|......|.:....|..
Human   497 AKPLQSSSPRVLGLPSRMEPPAP---------LSTSSTSQASALPPAGRRNLAESSGVGRVGAGS 552

  Fly   596 PRKPLRASVGSPLRSEESSPTTSLSSITSPMRKKRQ-------APLPPIQTDFDSDPGFSKLSDE 653
            ..||     .:|:...:|  ||....:::.:::.::       |.|.|:          .:.|..
Human   553 RPKP-----EAPMAKGKS--TTLTQDMSTSLQEGQEDGPAGWRANLKPV----------DRRSPA 600

  Fly   654 QKALLHTQLKA---PNLGDSTRR------------LIPLDQSLLSDEATESSNYDESLSTSNADE 703
            ::.|...:.:|   |..|::.|:            |.|    :..|.....::...||...:...
Human   601 ERTLKPKEPRALAEPRAGEAPRKVSGSFAGSVHITLTP----VRPDRTPRPASPGPSLPARSPSP 661

  Fly   704 EVNVVYRRILVP-------------PTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGK 755
            ...   ||:.||             |...|..|:..||::|.|.:.....|.:||..
Human   662 PRR---RRLAVPASLDVCDNWLRPEPPGQEARVQSWKEEEKKPHLQGKPGRPLSPAN-------- 715

  Fly   756 WKRRKGPAPAVP-----IPPRKVLQRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSL 815
                   .||:|     .|.|.....|..:||:.:.:.|..:...||.:||.|||.:|
Human   716 -------VPALPGETVTSPVRLHPDYLSPEEIQRQLQDIERRLDALELRGVELEKRLR------- 766

  Fly   816 DATDTDGPESAEVLTNSKEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIR 880
             |.:.|..|           :.|::..|.|::||..|.|:::||||..:..|||::|.|||.|:|
Human   767 -AAEGDDAE-----------DSLMVDWFWLIHEKQLLLRQESELMYKSKAQRLEEQQLDIEGELR 819

  Fly   881 VLMGQPEHNKTDSDKAHEEVLINRLVKVVEMRNEVIDSLETDRVREAREDMSIKNRLHIYNSERE 945
            .||.:||..|:..::..|:.|:.:.|..|..|::::|||:.||:||..||..:::.:       |
Human   820 RLMAKPEALKSLQERRREQELLEQYVSTVNDRSDIVDSLDEDRLREQEEDQMLRDMI-------E 877

  Fly   946 EPPAHPRSADKSSKKLSKKERKKLKEENKLGKGKKSDLDKDVDESEQA---PALEKVKKKRNL 1005
            :||............::||:::.|........|.......|:|....|   |......:.|.|
Human   878 KPPEEEVQVPLVQDLVTKKQKQPLPVVASRAVGSARTWHPDLDSGPWAWPGPGTRTCTRGRGL 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	63/96 (66%)
		LIM_like_1	146..207	CDD:188784	18/60 (30%)
		DUF3585	778..933	CDD:288945	53/154 (34%)
MICALL2	XP_011513822.1	CH	5..102	CDD:278723	63/96 (66%)
		LIM_Mical_like_1	188..241	CDD:188828	18/65 (28%)
		DUF3585	736..872	CDD:288945	53/154 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186776at33208
OrthoFinder	1	1.000	-	-		FOG0002858
OrthoInspector	1	1.000	-	-		otm40442
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5658
SonicParanoid	1	1.000	-	-		X4926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.960