DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICAL-like and mical1

DIOPT Version :9

Sequence 1:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster
Sequence 2:	NP_001303659.1	Gene:	mical1 / 568573	ZFINID:	ZDB-GENE-081022-3	Length:	1214	Species:	Danio rerio

Alignment Length:	977	Identity:	205/977 - (20%)
Similarity:	333/977 - (34%)	Gaps:	360/977 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTAEKYLG 83
            ||:..|.||..|||::::.|||:|||.||:||.|||:|:|...|...:|.:||.|||...||..|
Zfish   517 WCQKNTVGYEHVKVKDLSESWRSGLALCALIHSFRPELVDMSALDEYNIIKNNKLAFDLMEKEFG 581

  Fly    84 IPALLDAADMVSYEVPDRLSILTYLSQFYKVLGK------------------------------- 117
            |..::...||::....|:||::.||:|....|.:
Zfish   582 ITPIMRPGDMMTCGKIDQLSMVVYLTQIRNALTEKDTPAAQSNTLSLSRKRSAVAFLNTLKRNSL 646

  Fly   118 --------SLKHPK-------------PEEPLGEES---EPPQKVMHIVGMPRRDKCQKCNLPVF 158
                    |:|.|:             .||.|..|:   ||               |..|...::
Zfish   647 QRHKDRLASVKGPRQQNMKEKEEKKDVKEESLSSETSACEP---------------CYFCKKHLY 696

  Fly   159 LAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPDEESEPESDILKLKTTTTD 223
            :.||.....:.:||:|..|.:|.|.|..|.:.....|..:.||.
Zfish   697 VVERESAEGKFFHRSCFNCFQCGSTLRQGGYSFHSDNGRFYCEL--------------------- 740

  Fly   224 SPNDKQMVAQSSDYSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPI-LSEER 287
                         :|.||:::.|      ......:|.....:|:::|.|.|.....|. ||.:|
Zfish   741 -------------HSLAEEEEGD------EGHGGAQNHTENGSKEDKNGETTAASSPPAHLSIKR 786

  Fly   288 KISF-IPLDEEDGGLIEQYNKSTTPVKPAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPENDIPK 351
            |.|: |.:|.:       :::||....|...|.|                   ||..|.:...|.
Zfish   787 KGSYKISVDPD-------FDESTEFPAPDQDEPP-------------------DLEESHQPPKPS 825

  Fly   352 EKLKISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPEDHIS 416
            |                    :..:|.:.:...:|.:....|....||:|:
Zfish   826 E--------------------LSAENTNMENQQHNINPVPAPRGSRAPLPK-------------- 856

  Fly   417 PRKENKIFSNTESCSKQEGVLPKQMDL--ESPKDKVIETKASETDYPEDLNPFKDDDSSKGANPF 479
            ||..:.:..  |.|:     :|::.:.  |.||.|....|..:
Zfish   857 PRTVHNVVH--EPCN-----IPEEAEQIPEEPKPKPSLRKLQQ---------------------- 892

  Fly   480 DSSDDEVELLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKPHSSPTLSHGKKMPMPTPRISI 544
             |.:::|:||......:::|
Zfish   893 -SEEEKVDLLSQDSDSETRG--------------------------------------------- 911

  Fly   545 SKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRGSSISLPSANGPRKPLRASVGSPLR 609
                        ....:|.||||.:|      .:.|....|:                :.|...|
Zfish   912 ------------SSSAASTSSSSKQH------EEEGYWSGGT----------------TWGKSHR 942

  Fly   610 SEESSPTTSLSSITSPMRKKRQAPLPPIQTDFDSDPGFSKLSDEQKALLHTQLKAPNLGD--STR 672
            .:.:.|.         :|:|.:.|||.        .|.|:....:.......|.:|.|..  |..
Zfish   943 EQRNRPC---------IRRKSEPPLPL--------TGHSQHGKMRSKFSPWNLSSPRLQQRFSVH 990

  Fly   673 RLIPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYRRILVPPTQPENTVERSKEDQKSPIVYN 737
            | :|..||......:|..|.|:    .:.|||           ..|.|:.::....|    ..::
Zfish   991 R-VPAGQSQPDQYVSEDDNEDD----EDEDEE-----------DLQAEHYLDCEGAD----FEFS 1035

  Fly   738 DFD-RNVSPLGHNKSTHGKWKRRKGPAPAVPIPPRKVLQRL-PLQEIRHEFEIIAVQQLGLEKQG 800
            |.: ||:..:   |:...|.|..:             :||. ..|.|:...|.|.|....||::|
Zfish  1036 DSEKRNLKRM---KTLERKAKMTE-------------IQRFHKAQSIQRRLEEIEVTFKELEEKG 1084

  Fly   801 VILEKMIRDRCERSLDATDTDGPESAEVLTNSKEVEDLILQLFELVNEKNELFRRQAELMYLRRQ 865
            |.||:.:|..       |.|..||             :|.|..|||.|||.|...:::||...||
Zfish  1085 VELERALRGE-------TGTGDPE-------------IIDQWIELVQEKNNLLSEESDLMVASRQ 1129

  Fly   866 HRLEQEQADIEHEIRVLMGQPEHNKTDSDKAHEEVLINRLVKVVEMRNEVIDSLETDRVREARED 930
            ..||.:|:.:|.|:|..|...:..|:...:.||..::..::.||:||:.::..||..|::|..:.
Zfish  1130 LELEDKQSMLEMELRRYMEMDDSEKSPEQQKHEAEILQEMLDVVDMRDSLVAFLEEKRLKEVNDQ 1194

  Fly   931 MS 932
            .:
Zfish  1195 FN 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	41/91 (45%)
		LIM_like_1	146..207	CDD:188784	15/60 (25%)
		DUF3585	778..933	CDD:288945	47/155 (30%)
mical1	NP_001303659.1	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	1..488
		NAD_binding_8	90..>133	CDD:290186
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505
		CH	512..609	CDD:278723	41/91 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..676		3/26 (12%)
		LIM_Mical	688..742	CDD:188823	15/87 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..1019		77/479 (16%)
		DUF3585	1062..1193	CDD:288945	47/150 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1194..1214		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910