DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICAL-like and mical3b

DIOPT Version :9

Sequence 1:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster
Sequence 2:	XP_017210768.1	Gene:	mical3b / 566850	ZFINID:	ZDB-GENE-050211-1	Length:	1735	Species:	Danio rerio

Alignment Length:	1267	Identity:	267/1267 - (21%)
Similarity:	421/1267 - (33%)	Gaps:	416/1267 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTAEKYLG 83
            ||:..|.||..|.|.:.|:|||:|||.||:||.||||||||..|:..:...:..|....||:..|
Zfish   521 WCQEHTHGYRKVCVTDFTSSWRSGLALCALIHTFRPDLIDFASLEESEAEFSGQLGLDVAEQEFG 585

  Fly    84 IPALLDAADMVSYEVPDRLSILTYLSQFYKV--------------------------------LG 116
            |..::...:|...|..|.|.::.||||.:::                                ||
Zfish   586 ICPIMTGKEMSVLEESDSLCMVMYLSQLHELLKDTSPPSGSQSSEERAVLFSSSRSPISLLSKLG 650

  Fly   117 KSL---KHPK------------------------------------PEEPLG------------- 129
            :||   ::||                                    |.|..|
Zfish   651 QSLSRKRNPKDKKEKEADSVGKRRRTSQAGQSEEEDALHDGNENKSPAETPGSEPKASEGHSKVR 715

  Fly   130 ----------EESEPP--------QKVMHI----------------------------------- 141
                      ||:.|.        |..:|:
Zfish   716 SMASLLLAKFEENSPSPSTTAIRRQNYIHMYTGGVSSLALQIANQIQSQQAQAPKLLHRRESGSQ 780

  Fly   142 ----VGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCE- 201
                |.:...|.|..|...|::.||:....:.:||:|.:|..|||.:...::...:::..:.|:
Zfish   781 KDLPVNVGSSDVCYFCGRRVYVMERLSAEGKFFHRSCFQCDHCSSTIRLSNYTYDQLHGKFYCKH 845

  Fly   202 --------------TCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQEDLEDN-D 251
                          ..|.....|....|...:.:| |.:....|..::..|.:.....|:..: .
Zfish   846 HFSFRLASVAQRKRPAPPVAPRPAQASLAASSAST-SLSSLGSVGTATPDSWSSSTHTDMASSLA 909

  Fly   252 IRTTDKP-----ENFQPPSNKDEQNNELTINPVNPILSEERKISFIPLDEEDGGLIEQYNKSTTP 311
            .|....|     ||::|...|.:.                      ||.|.....:.|:|.|.:.
Zfish   910 KRLCGTPERIELENYKPSPQKQDS----------------------PLQEVPEETLAQHNLSASL 952

  Fly   312 VKPAIPEKPKVSTLPLDDEQ---------HAGV--EQNNDLAVSPENDIPKEKL------KISSV 359
            .:....|:...|...|::|:         ||..  |:..||....:.:...|||      :...|
Zfish   953 QEKNAEEQSSSSESDLEEEELVWKKGEELHARTNGERKLDLEEELKEEEGGEKLEKQEGEEEGEV 1017

  Fly   360 SIYLEDDRLVVDAIHPDNLDKQE----ALNNTSDALIPESQEAPIPENNTQVAIKPEDHISPRKE 420
            |...:|:        .|:.|:.|    .....|...:.|.:...:.|:....:..|:..:|...|
Zfish  1018 SEEEQDE--------GDSSDEGEYCPWERERLSGVWLEEEEAGFVKESYEGCSDDPDIDVSSLSE 1074

  Fly   421 NKIFSNTESCSKQEGVLP---KQMDLESPKDKVIETKASETDYPEDLNPFKDDDSSKGANPFDSS 482
            :|:....|    ||..:|   .....|||    :..|.||:    ||.|  |..::..::|...|
Zfish  1075 SKLCDQRE----QEESVPFHQSPASTESP----VSMKPSES----DLTP--DPSTTPESSPAKRS 1125

  Fly   483 DDEVEL-LKAIPAQQSKGKVVPPRPPPPK-IGLSS-ISNPSEKPHSSPTLSHGK-KMPMPTPRIS 543
            :...|. :|:...::|.|.....|...|| |..|: .||..|..::|.|.:... ..|..:.||.
Zfish  1126 EVVEEFWMKSAEIRKSLGLTPLSRELQPKHIAASTQTSNVKESFYTSVTYNTAALDSPNQSARIC 1190

  Fly   544 ISKTQT----------PAKPMTHQGQKSSISSSSSEHLNSIRTFDRG---ADDRG--------SS 587
            .|.|||          |..| |.......:...|..|..||..  .|   ||::|        .|
Zfish  1191 DSSTQTHSVTDLQETSPLGP-TDGDAGVDLGRCSVVHRLSITV--EGCVMADNQGLDSTSFATES 1252

  Fly   588 ISLPSANGPRKPLRAS----VG---------SPLRSEESSPTTSLSSITSPMRK------KRQAP 633
            :..|.|..|..|...|    ||         .|:...|....:|..:.:.|.|.      ::...
Zfish  1253 VLNPDAGLPTPPYSPSHSPLVGKQCRALHHSEPILDREVMAFSSTCTASVPQRSSFKSDLEQAQS 1317

  Fly   634 LPPIQTDFDSDPGFSKLSD---------------EQKALLHTQLKAPNL-GDSTRRLIPLDQSLL 682
            |||.:.:........||.:               |....|..::.||.| |....||...:..|.
Zfish  1318 LPPDEIEILCGDEAEKLPERSCRMESGEVDNRRAEHSRTLPDRVVAPLLAGGPEVRLRRSEMKLW 1382

  Fly   683 SDEATESSNYDESLSTSNADEEVNVVYRRILVPPTQPE---NTVERS------------------ 726
            ..:               ||.:|....|..|..|.:..   |....|
Zfish  1383 GPD---------------ADGDVKEKKRSSLFSPRKSRKNGNAAAESGRETGKHKSLWKTVFSVY 1432

  Fly   727 KEDQKS----------PIVYNDFDRNVSPLGHNKSTHGKWKRRKGPAPAVPIPPRKVLQRLPL-- 779
            |:|:|.          |...|...|.||  |.|::|...:::....:....:....:|:|.||
Zfish  1433 KKDKKRKEVAVVAETLPAANNGSKRKVS--GINRTTDLCFRKNPSFSEDTDMSCHALLERCPLRA 1495

  Fly   780 ------------------------------------QEIRHEFEIIAVQQLGLEKQGVILEKMIR 808
                                                |.|:.:.|.:.|:|..||::||.:||.:|
Zfish  1496 QRAGTEEELNARLTRRVQRAARRQAKQEELRRLHRAQIIQRQLEQVEVKQRQLEEKGVAVEKALR 1560

  Fly   809 DR-------------------CERSLDATDTDGPESAEVLT-----------------NSKEVED 837
            ..                   |.....|..|:...|..|.|                 ..|:...
Zfish  1561 GEAVEPFDGSPRRRPVYLCPCCSSEAKAKGTEHDHSVYVCTVFFLYVVQEPPLHQLRMGKKDDPS 1625

  Fly   838 LILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAHEEVLI 902
            |:.|.|:||.|||.|.|.::|||...|:..||..|:.::.|:|..|...:|.|.:.:.|.|..::
Zfish  1626 LMHQWFKLVQEKNALVRYESELMIFARELELEDRQSRLQQELRERMAVDDHLKGEEELAEERRIL 1690

  Fly   903 NRLVKVVEMRNEVIDSLETDRVREAREDMSIK 934
            :.::.|||.|:.::..||..||||..||..::
Zfish  1691 SEMLDVVEQRDALVALLEEQRVREKEEDSDLE 1722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	39/91 (43%)
		LIM_like_1	146..207	CDD:188784	15/75 (20%)
		DUF3585	778..933	CDD:288945	57/228 (25%)
mical3b	XP_017210768.1	FAD_binding_3	86..>140	CDD:332373
		CH	518..613	CDD:306753	39/91 (43%)
		LIM_Mical	793..847	CDD:188823	13/53 (25%)
		DUF3585	1534..1721	CDD:314926	54/186 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910