Protein Alignment MICAL-like and Mical

DIOPT Version :10

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: NP_001247015.1
• Gene: Mical / 41225
• FlyBaseID: FBgn0053208
• Length: 4743
• Species: Drosophila melanogaster
• Alignment Length: 1355
• Identity: 237/1355 - (17%)
• Similarity: 407/1355 - (30%)
• Gaps: 538/1355 - (39%)

  Fly   148 DKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSF---YETEVNNIYCCE-------- 201
            :||:.|...|:|.|:..|.....||.||||..|.:.|..|.:   .:......||.:
  Fly  1095 EKCRFCKQTVYLMEKTTVEGLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRLPPKP 1159

  Fly   202 --------------------TCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQED 246
                                ..|...|.|.:........|| .|.|:..:.::|..:.:.|...|
  Fly  1160 LPQRTNKARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTT-PPRDQVDLLETSRANASADAMSD 1223

  Fly   247 LEDNDIRTTDKPE----NFQPPSNKDEQNNELTINPVNPILSEERKI------------------ 289
            .|.|.|   |:.|    ||.|.||.|.| :||:.:..:...|:....
  Fly  1224 DEANVI---DEHEWSGRNFLPESNNDSQ-SELSSSDESDTESDSEMFEEADDSPFGAQTLQLASD 1284

  Fly   290 --------------SFIPLDEEDG-----GLIEQYNKSTTPVKPAIPEKPKVSTLPLDDE----- 330
                          .|....|:||     |  |::.|:....:..:..:|..:.||.|.|
  Fly  1285 WIGKQYCEDSDDSDDFYDSSEDDGKDDTEG--EEFKKARELRRQEVRLQPLPANLPTDTETEKLK 1347

  Fly   331 --------------------------------------QHAGVEQNNDLAVSPENDIPKEKLKIS 357
                                                  :...:|:|.....|.|.:...|||...
  Fly  1348 LNVDNKENMADRSSLKSGNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIEAISEKLYHM 1412

  Fly   358 SVSIYLEDDRLVVDAIHPDNLDKQEALNN--------------------------TSDALIPESQ 396
            :..:.:..|   ::.:..:||.|.:.|..                          |:..|.|:|:
  Fly  1413 NNMVKMNKD---LEVLAKENLVKSDILRKLTLKEKWLAENAAIAAGQKVTPTPSATAPGLQPKSK 1474

  Fly   397 -----EAPIPENNTQVAIKPE-------DHISPRKENKIFSNTESCSKQEGVLPKQMDLESPKDK 449
                 |..:......|..||:       |.:.|||     .|.|...|::  ||:...|:.|..:
  Fly  1475 FDEKFEKVVSPPQPVVEPKPKPVIDFNLDELKPRK-----PNFEERPKEQ--LPRPESLKKPPQQ 1532

  Fly   450 VIETKASETDYPEDLNPFKDDDSS----------------------------KGANPFDSS---- 482
              :.|.|.|:.... |..|.:.|:                            :..|..|..
  Fly  1533 --KPKGSSTNVSRS-NSLKSNASNGSPKVKKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMD 1594

  Fly   483 -DDEVE---------LLKAIPAQQSKGKV--------VP--PRPPPPKIGLSSISNPSEKPHSSP 527
             |::||         .||.|.|....|.:        :|  ....||.:.||... |::|...|.
  Fly  1595 VDEDVERKPNKELNSKLKEIQASSFAGTMDHIKSQLTMPTVSAQAPPSMDLSKYF-PNQKQEKSS 1658

  Fly   528 TLSHGKKM---------------PMPTPRI------SISKTQTPA-------------------- 551
            |.|..|..               |.|..|.      .:.|:||.|
  Fly  1659 TSSTNKNQVTLKDVNLAKYFPSSPAPQRRTVETVADRLKKSQTEAALAKTKLLEDQANNQAEKTK 1723

  Fly   552 KPMTHQGQKSSISSSSSE-------HLNSIRTFDRGADDRGSSISLPSANGPRKPLRASVGSPLR 609
            |.:..:|:...|:...::       ...|:.||.........::.|....||.|   ||.|.. :
  Fly  1724 KEVEKEGESKKITKKVADSKAVPPKRQASLDTFSLREHQMDGALDLTKKKGPTK---ASAGVK-K 1784

  Fly   610 SEESSPTTSLSSITSPMRKKR---------------------------QAP---LPP------IQ 638
            ..:|..|||::..|:..:.|.                           :||   .||      |.
  Fly  1785 PAKSGSTTSVTKATATSKGKTIKIVKKIVPKGTKAKKAAEAAQESAVVEAPPEKKPPKDEAERIL 1849

  Fly   639 TDFDSDPGFSKLSDEQKALLHTQLKAPNLGDSTRRLIP---LD----------QSLLSDEATESS 690
            .:...|..:...|.|.:.|...:....:|.|:..|::.   ||          :.|:..::....
  Fly  1850 DEILGDGEYRSPSSEYQRLFQDEKSPSDLSDNIDRILEESGLDVELGLPKRSSKKLVKTKSLGEG 1914

  Fly   691 NYD---------------------ESLSTSNADEEVNVVYRRI----------------LVPPTQ 718
            ::|                     .|:::.|:||:.....||:                ||..:.
  Fly  1915 DFDMKPSKERLTGVQNILKRFESMSSVTSQNSDEQAAFKLRRMESTTSNLSSLTRSRESLVSVSD 1979

  Fly   719 PENTVERS--------------------------KEDQKS--------------PIVYND----- 738
            ..:.:|::                          ||:|:.              |:.|.|
  Fly  1980 SMSDLEKTMDYLRNEWRNEATNFLQKKRDKFYAKKEEQEKESKILAKPDPLDNLPVQYRDSKLAK 2044

  Fly   739 -FDRNVSPLGHNKSTHGKWKRRKGPAPAV-------------------------PIPPRKVLQRL 777
             |....|....|:.:..|.|:.....|.|                         .:.|.:|....
  Fly  2045 FFGLAASKSPENRKSPIKKKKSPSKTPKVTKANNSLEELAKISNVRQTKKAQPKTLKPVEVKPLK 2109

  Fly   778 PLQEIRHEFEIIAVQQLGLE---------------------KQGVI--------LEKMIRDRCER 813
            |...:..:|||:.:.:...|                     |:.::        ::.:.:..|::
  Fly  2110 PASPVPDDFEILDLLEKATEAKELERSKTKSPAVESISQTPKEAIVEISLPVEDIKNLPKTGCDK 2174

  Fly   814 SLDATDTDGPES-------AEVLTNSKEVEDLILQLFELVNEK-----NELFRRQAELMYLRRQH 866
            |.:::......|       :|:..|.|..:|.:..|.::..|:     :|||:...|.|....|.
  Fly  2175 SSNSSRRGSQSSLIMSRRHSEISLNEKLNQDALAALNQIEKEREAEQVDELFQSMVEEMEQEPQP 2239

  Fly   867 R--LEQEQADIEHE---------------IRVLMGQPEHNKTDSDKAH--EEVLIN-------RL 905
            .  :|..:.||:.:               ..|..|..|....:...:|  :|:|:|       .|
  Fly  2240 TAIVEPPEEDIDADSLCTTISKSPSAQPVTVVKRGSSEDQSIEKLFSHFSDEMLVNVEFDSNDEL 2304

  Fly   906 VKV-----VEMRN-------EVIDSLETDR-----------VREAREDMSIKNRLHIYNSEREEP 947
            |.:     :..||       :.::|||.|.           ::|..:|.  .:.||.    ...|
  Fly  2305 VGITPRATLVSRNTEDRDYLDKLESLERDEETFQPVVGEKFIQENVQDE--VDGLHF----PSRP 2363

  Fly   948 PAHPRSADKSSKKLSKKERKKLKEENKLGKGKKSDLDKDVDESEQAPALEKVKKK 1002
            ...|:|:..||:.......::||:  ||.|....|:...|.:     .|::|.:|
  Fly  2364 QRRPKSSSSSSEPSLPVAPQRLKK--KLSKLDPEDMPPSVQD-----LLQQVYQK 2411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102
		LIM_like_1	146..207	CDD:188784	19/89 (21%)
		PTZ00449	<411..727	CDD:185628	90/534 (17%)
		bMERB_dom	785..933	CDD:463467	40/237 (17%)
Mical	NP_001247015.1	UbiH	128..>263	CDD:440419
		CH_SF	567..669	CDD:469584
		LIM_Mical	1097..1153	CDD:188823	17/55 (31%)
		PRK10819	<1450..>1557	CDD:236768	25/116 (22%)
		bMERB_dom	4592..4705	CDD:463467