DRSC/TRiP Functional Genomics Resources

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Protein Alignment MICAL-like and mical3a

DIOPT Version :9

Sequence 1:NP_648621.1 Gene:MICAL-like / 39475 FlyBaseID:FBgn0036333 Length:1010 Species:Drosophila melanogaster
Sequence 2:XP_021323435.1 Gene:mical3a / 402881 ZFINID:ZDB-GENE-050126-2 Length:2522 Species:Danio rerio


Alignment Length:1987 Identity:297/1987 - (14%)
Similarity:501/1987 - (25%) Gaps:1087/1987 - (54%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 WCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTAEKYLG 83
            ||:..|:||.||.|.::||||::|||.||:||.:|||||||:.|...|:.:||.|||..||:..|
Zfish   539 WCQRQTEGYRGVSVSDLTTSWKSGLALCALIHRYRPDLIDFESLDEKDVEKNNQLAFDVAEREFG 603

  Fly    84 IPALLDAADMVSYEVPDRLSILTYLSQFYKV---------------------------------- 114
            |..::...:|.....||:||::.||||||::                                  
Zfish   604 ISPIMTGKEMSVVVEPDKLSMVMYLSQFYEMFKDTVPPGENQNLSPEEKAALIASTKSPISFLSK 668

  Fly   115 LGKSL-----KHPKPEE------------------------------------------------ 126
            ||:|:     ::||.::                                                
Zfish   669 LGQSIAISRKRNPKDKKEKELDGLGKRRKTSQAGQSEDEELQRANRDDRPSIATALAERKIDSAA 733

  Fly   127 ---------------------------------------------------PLGE---------- 130
                                                               ||.|          
Zfish   734 AANNNNKVKSMATQLLAKFEENAPTQSTGLKRQGDSMPDLGLILTPSPAAAPLNESVRLAPVPAW 798

  Fly   131 -----------------------------------------------------------ESEPP- 135
                                                                       .|.|| 
Zfish   799 RKRRTQLQEQMSFRYKEKLKCQTLPITQEQASSGTEVLRSCPKKTILLSSSSPSSSSFSSSFPPH 863

  Fly   136 -QKVMH----------------------------------------------------------- 140
             |.|:|                                                           
Zfish   864 AQSVIHKCNGVGDGENRFQDLSVCYWEDNLPNVDKPEPIHIRSIQERAETLVARFKGKADRKDKP 928

  Fly   141 -IVGMPRR--------------------------------------------------------- 147
             ::..|.|                                                         
Zfish   929 QVMKKPSRFFIEQWFLTHGLSPDEPVFSSDPQHHQQKGVLCPDDHVPLHIPSIQERAERLASHFK 993

  Fly   148 ----------------------------------------------------------------- 147
                                                                             
Zfish   994 DKPAKPKSKKKSSLLLTEQWSRARDVSSASPLHSPSSFRQHCVKMYTGGVSSLAEQIANQLQAKD 1058

  Fly   148 -------------------------DKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPG 187
                                     |.|..|...|::.||:....:.:||:|.||..|.:.|...
Zfish  1059 DPRPMLEKRDLGSFRKEFPQNIGGSDVCFFCRKRVYVMERLSAEGKFFHRSCFKCDYCGTTLRLS 1123

  Fly   188 SF-YETEVNNIYC----C--------------ETCPDEESEPESDILKLKTTTTDSPND------ 227
            |: ::.|....||    |              ...|....||:  :|.:...|.|:|..      
Zfish  1124 SYAFDVEDGKFYCKPHYCYRLSGVAQRKRPAPAAAPANAKEPQ--VLAVSPNTVDAPGQAITTQT 1186

  Fly   228 -------------------------------------------------KQMVAQ---------- 233
                                                             ::.:|:          
Zfish  1187 PAERRPSETEVNGVTEPSVAKRLKGTPERIELENYRLSMMREEELEEVPEETLAEHNLSSVLDKA 1251

  Fly   234 -------SSDYSEAEDKQED------------------------------------LEDNDIRTT 255
                   ||..|:.|::.||                                    |.|.|....
Zfish  1252 TDIEEGSSSSESDMEEEDEDAEAAGPSDLGGVPWKEAVELHAKLKGESDPGADDDGLHDGDGEMD 1316

  Fly   256 DKPENFQPPSNKDEQNNELTINPVNPI--------------LSEERKISFI-------------- 292
            :..|..:...::||:..|.:....:..              |:.|..:|..              
Zfish  1317 EDEEEEEDEEDEDEEEEEESSEAGDYFPWERELQSGLWLENLANEEDVSVFKARNLQIQQAIHPV 1381

  Fly   293 -PLD-----EEDGGLIEQYNKSTTPVKPAIP---EKPKVSTLP-------------LDDEQHAGV 335
             |||     .:..|::|..:.|....:|::.   .:|..||.|             ||.......
Zfish  1382 DPLDIQMESHQAEGVLEMPSVSPLGSQPSLNTQLTQPTSSTAPSHKSVRHEAVRAWLDSMSGEPC 1446

  Fly   336 EQNND---LAVSP---------ENDIPKE-KLKISS------VSIYLEDDR-------------- 367
            |:::|   .|.||         :.|||.: :.:..|      |::.:::|:              
Zfish  1447 EEDDDPEAEAGSPDFEPGTEIDQEDIPSDAEAEARSRCIDEVVTLPVDNDKTESQGQVFNTAEKT 1511

  Fly   368 ------LVVDA--------------IH---------------------PDNLDKQEALNNTSDAL 391
                  |:||.              :|                     ||.:.:......:.|..
Zfish  1512 SANPRELIVDVVLSPIQKPALPIEEVHEVSPVVLVKSPGARFFPEPYLPDKVKQNIPPPQSPDVK 1576

  Fly   392 IPESQEA-----------PIPENNT----------------------------QVAIKPEDHIS- 416
            .|.|..|           |:|:..|                            |...:|...:| 
Zfish  1577 TPHSPVAQIIALSPICSQPVPQPGTASPKSPVQPQPCACSPTGNPLSPICTQSQPCNEPPSPLST 1641

  Fly   417 -------------------PRKENK----IFSNTESCSKQE----------------GVLPKQMD 442
                               |..||:    :..:|....|.:                |:.|.:..
Zfish  1642 SSPVRTQPVPAVTSTPLAKPASENRTNEHLKDSTPELKKTDLIEEFWLKSAEIRKSLGLTPLERS 1706

  Fly   443 LESPKDKVIETKASETDYPEDLNPFKD------------------------------DDSSKGAN 477
            ..:.:..:::|...|:..|:...| :|                              :..|.|:.
Zfish  1707 KTAVEKSIVKTPTPESSSPKSYTP-EDLSEEQKPTFTGRSIIRRINITLEGQVISPVEPKSNGSE 1770

  Fly   478 PFD-SSDDEVELLKAIPAQQSKGK----------VVPPRPPPP---------------KIGLSSI 516
            ..| ||...:.|..::...|:...          :.||..|||               ::...::
Zfish  1771 KKDLSSSSGLGLNGSVTTSQTAASDSYNNSDSTMLTPPSSPPPPPPREEPACLQNKKSQVSWDNL 1835

  Fly   517 SNPSEKPHS-----------SPTLSHGKKM--PMPTPRIS---ISKTQTPAKPMTHQGQKS---- 561
            ...:|:|.|           ||.....|.:  |:||||.:   :.:.:.|.||...:.:||    
Zfish  1836 LEGTEEPKSETMPIKPRTPVSPPQPKQKPVTAPVPTPRTNPPVVMRVKEPNKPRREEVRKSFVEC 1900

  Fly   562 ----------------------------------------------------------SISSSSS 568
                                                                      |.::..|
Zfish  1901 VDEIPFADDVEDTYDDRTPDASGLEKFYTPPTSKVNRDKPPLHLALAMENGKPNIPGVSRTAKGS 1965

  Fly   569 EHLN----------------SIRT------------------FDRGA---------DDRGSS--- 587
            :|.:                |:::                  ..:||         :.:|.|   
Zfish  1966 QHFSPEAKEIAEERMRAREKSVKSQALKDAMAKQLTKMKDSEVAKGAVAKVAWDIPETKGKSKKQ 2030

  Fly   588 -------------------------ISLP-------------SANGPRKPLRASVGSPLRS---- 610
                                     .|.|             |:.|.:...|:|:.||.::    
Zfish  2031 SKAQKDSAVKALESKKQADTLPDRFFSTPSSKALDSSVTSSESSTGGKSKKRSSLFSPRKNKKEK 2095

  Fly   611 ------------------------------------EESSPTTSLSSITSPMRKKRQAPLP---- 635
                                                ::|.|:|..||.|....||:.:||.    
Zfish  2096 KAKNERLSSTEETPPKHKSLWKAVFSGYKKDKKKKDDKSCPSTPSSSTTGDSGKKKDSPLDRSSD 2160

  Fly   636 ---------PIQTDFDSDPGFSKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQS--LLSDEATES 689
                     ...:|...|....:.|.:.|...|..| ...:.|..:..|..:::  ...|.|.|.
Zfish  2161 LRLRRNLSFSEDSDLSCDDVLERSSQKSKGDRHVDL-FDLVSDLKKEAIKEEKAKEKAKDRAKER 2224

  Fly   690 SNYDESLSTSNADEEVNVVYRRILVPPTQPENTVERSKEDQKSPIVYND----FDRNVSPLGHNK 750
            ....|.....:.:.|.....:..:|.....|.  |:.||::.   ||..    |.|:.:    .|
Zfish  2225 GRVTEKGKERSRERENEKRVKEKMVKMKDVER--EKGKEEES---VYVPHALAFKRSYA----TK 2280

  Fly   751 STH------GKWKRRKGPAPAVPIPPRKVLQRL-PLQEIRHEFEIIAVQQLGLEKQGVILEKMIR 808
            .|:      .|..||...| |.....::.|:|| ..|.|:.:.|.:..:|..||::||.:||.:|
Zfish  2281 KTYTEEELNAKLTRRVQKA-ARRQAKQEELKRLHRAQMIQRQLEQVEEKQRQLEERGVAVEKALR 2344

  Fly   809 DRCERSLDATDTDGPES-------------AEVL----------------------------TNS 832
            .  |..|....:..|:.             :|:|                            ...
Zfish  2345 G--EAGLYKGSSVSPKQRKRRSDYWGESNYSEILDLHLGVEPYVGTPRRRALYLCPCCAPEGMGK 2407

  Fly   833 KEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAH 897
            |:...|:.:.|:||.|||.|.|.::|||...|:..||..|:.::.|:|..|...:|.||:.:.|.
Zfish  2408 KDDPKLMQEWFKLVQEKNALVRYESELMIFARELELEDRQSRLQQELRERMAIDDHLKTEEELAE 2472

  Fly   898 EEVLINRLVKVVEMRNEVIDSLETDRVREAREDMSIK 934
            |:.::|.:::|||.|:.::..||..|:||..||..::
Zfish  2473 EKQILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLE 2509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MICAL-likeNP_648621.1 CH 14..111 CDD:278723 45/91 (49%)
LIM_like_1 146..207 CDD:188784 20/226 (9%)
DUF3585 778..933 CDD:288945 53/195 (27%)
mical3aXP_021323435.1 FAD_binding_3 91..>239 CDD:332373
CH 536..636 CDD:306753 48/96 (50%)
LIM_Mical 1086..1140 CDD:188823 16/53 (30%)
Herpes_BLLF1 <1488..1803 CDD:330317 37/315 (12%)
DUF4045 <1840..>1896 CDD:330572 14/55 (25%)
SMC_N <2220..>2506 CDD:330553 75/297 (25%)
DUF3585 2318..2508 CDD:314926 52/191 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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