DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICAL-like and Micall1

DIOPT Version :9

Sequence 1:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster
Sequence 2:	XP_038936207.1	Gene:	Micall1 / 362958	RGDID:	1305415	Length:	866	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	259/1016 - (25%)
Similarity:	403/1016 - (39%)	Gaps:	294/1016 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DFDRLKADDIYENNDLAFTTAEKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVL------- 115
            ||..|..::::|||.|||..|||.||||||||..||||..|||.|||:||:||:|...
  Rat    62 DFQSLSKENVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFTSSGQAA 126

  Fly   116 ------GKSLKHPKP----------EEPLGEESEPPQKVMHIVGMPRRDKCQKCNLPVFLAERVL 164
                  ||....|.|          ||..|::..|..........|....|..|...|.|.:|.|
  Rat   127 ASPPKPGKDPAAPSPTSTSPAVQPGEEAQGDDLSPDSLSEQGKPQPPSSACAACGQRVHLVQRYL 191

  Fly   165 VGKRAYHRTCLKCARCSSLLTPGSFYE-TEVNNIYCCETCPDEESEPESDILKL--KTTTTDSPN 226
            ...|.|||.|.:|.:|||.|.|||:.. .|.....|.|.|..         |.|  ::.|.....
  Rat   192 AEGRLYHRHCFRCRQCSSTLVPGSYSSGPEEGTFVCAERCTR---------LGLGGRSGTRPLSL 247

  Fly   227 DKQMVAQSSDYSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEERKISF 291
            .||..|.:::..:.||  .||..:.:....:.:..|  ::.:.|.:.||
  Rat   248 QKQQPAAAAEAKDGED--SDLSKSVVVVAAEADGLQ--ASSEVQPHTLT---------------- 292

  Fly   292 IPLDEEDGGLIEQYNKSTTPVKPAIPEKPK-VSTLPLDDEQHAGVEQNNDLAVSPENDIPKEKLK 355
                                 ||.:|.||: :::.|:.....|..:.:...|::|....|:..
  Rat   293 ---------------------KPPLPSKPQDLASPPVSRPTPAPRKASESSALTPPTPRPRSS-- 334

  Fly   356 ISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKP-------ED 413
                   |:.|.:|..::             :.|.:....||.|:|        ||       |.
  Rat   335 -------LQQDGMVEQSV-------------SGDLVNGRLQELPVP--------KPRGTPKLSER 371

  Fly   414 HISPRKENKIFS--NTESCSKQEGVLP------------KQMDLESPKDKVIETKASETDYPEDL 464
            ..:|||:....:  .||. .|:...||            :|::....::|..::.|:|.: |:..
  Rat   372 MTAPRKDPPWITLVQTEP-KKKPAPLPPSSGPGPLSQASRQVENGGLEEKTQKSPAAEPE-PKPY 434

  Fly   465 NPFKDDDSSKGANPFDSSDDEVELLKAIPAQQSKGKVVPPRPPPPK---------IGLSSISNPS 520
            |||::::..:.|              ::||      |..|.|.||:         ..::..|:|.
  Rat   435 NPFEEEEEEEEA--------------SVPA------VPSPAPAPPETTPKSLHPWYNITPTSSPK 479

  Fly   521 EK-------PHSSPTLSHGKKMPMPTPRISISKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFD 578
            .|       |.:||.:.|..::....|.   |.|.:||..:      .|:||.||.|..:....:
  Rat   480 TKKRPAPKAPSASPLVLHASRLSHSEPP---SATPSPALSV------ESLSSESSSHTANTEPSE 535

  Fly   579 RGADDRGSSISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSI---------TSPMRKKRQAPL 634
            ..|..:.||.  |:.:.|..|     |:...|...|..:||||.         ..|..:.|.:|.
  Rat   536 PPAVPKSSSD--PAVHVPGTP-----GTSANSVTPSAHSSLSSSGELGQPSGEQMPQARTRGSPG 593

  Fly   635 PPIQTDFD-SDPGFSKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLST 698
            ......|. :.|....|:.:||:      .||.:|.|:.::
  Rat   594 THSTKPFSGATPTPFLLAGDQKS------PAPPMGSSSPQM------------------------ 628

  Fly   699 SNADEEVNVVYRRILVPPTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPA 763
                          |:..:..||...|......||.|             .|:|.|. |..:.||
  Rat   629 --------------LIKSSCKENPFNRKPSPSTSPTV-------------RKATKGA-KPVRPPA 665

  Fly   764 P--AVPIPPRKVL--QRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTDGPE 824
            |  ..|:..|||.  |.:|.::|..|.:.|..|...||..||:||:.:|            .|..
  Rat   666 PGHGFPLIKRKVQADQYIPEEDIYGEMDSIERQLDALEHSGVLLEEKLR------------GGAN 718

  Fly   825 SAEVLTNSKEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHN 889
            .:|        :|:::..|:|::||:.|.||::||:|:.:|..|||.|||:|.|:|.|:.:||.:
  Rat   719 GSE--------DDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEFELRCLLNKPEKD 775

  Fly   890 KTDSDKAHEEVLINRLVKVVEMRNEVIDSLETDRVREAREDMSIKNRLHIYNSEREEPPAHPRSA 954
            .||.|:|.|:||:..|:.::|.|:.:::.|:.||.||..||..::..:...:.:||        |
  Rat   776 WTDDDRAREKVLMQELMTLIEQRDAIVNCLDEDRQREEEEDKMLETMIKKKDFQRE--------A 832

  Fly   955 DKSSKKLSK-KERKKLKEENKLGKGKKSDLDKDVDESEQAP 994
            :..|||..| |..|.||   .||..:        |...:||
  Rat   833 ESDSKKKGKFKTMKVLK---LLGNKR--------DAKSKAP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	33/52 (63%)
		LIM_like_1	146..207	CDD:188784	23/61 (38%)
		DUF3585	778..933	CDD:288945	55/154 (36%)
Micall1	XP_038936207.1	CH_SF	<62..122	CDD:412120	35/59 (59%)
		LIM_Mical_like_1	177..231	CDD:188828	22/53 (42%)
		PHA03247	<295..666	CDD:223021	98/496 (20%)
		DUF3585	688..809	CDD:403377	48/140 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353237
Domainoid	1	1.000	139	1.000	Domainoid score	I4665
eggNOG	1	0.900	-	-		E2759_2QWQX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2938
OMA	1	1.010	-	-		QHG47674
OrthoDB	1	1.010	-	-		D186776at33208
OrthoFinder	1	1.000	-	-		FOG0002858
OrthoInspector	1	1.000	-	-		otm44584
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.770