Protein Alignment MICAL-like and actn4

DIOPT Version :10

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_021337011.1
• Gene: actn4 / 322221
• ZFINID: ZDB-GENE-030131-940
• Length: 923
• Species: Danio rerio
• Alignment Length: 862
• Identity: 178/862 - (20%)
• Similarity: 286/862 - (33%)
• Gaps: 274/862 - (31%)

  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            :.|..||:..|..|..|.|:|...||::||||.|:||..||:|||:|:|:.||...|.:.||..|
Zfish   157 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIDYDKLRKDDPVTNLNNAFEVA 221

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLGKSLKHPKPEEPLGEESEPPQKVMHIVG 143
            |:||.||.:|||.|:|:...||..:|:||:|.||.....:.|
Zfish   222 ERYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK----------------------- 263

  Fly   144 MPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPDEES 208
                                                          .||..|.| |.....::|:
Zfish   264 ----------------------------------------------AETAANRI-CKVLAVNQEN 281

  Fly   209 EP--------ESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQEDLEDNDIRTTDKPENFQPPS 265
            |.        .||:|:....|.....::   |.....:|.:.|.||.  .|.|...|     ||.
Zfish   282 EHLMEDYEKLASDLLEWIRRTIPWLENR---APEKTMAEMQQKLEDF--RDYRRVHK-----PPK 336

  Fly   266 NKDEQNNELTINPVNPILSEERKISFIPLDEEDGGLIEQYNKSTTPVKPA-----------IPEK 319
            .:::...|:..|.:...|....:.:|:|   .:|.::...|.:...::.|           |...
Zfish   337 VQEKCQLEINFNTLQTKLRLSNRPAFMP---SEGRMVSDINGAWHKLEGAEKGYEEWLLNEIRRL 398

  Fly   320 PKVSTLPLDDEQHAGVEQ---NNDLAVSPENDIPKEKLKISSVSIYL------EDDRLVVDAIHP 375
            .::..|.....|.|.:.:   :...|:..:.|.  |...:|.:...|      |.|.    |.|.
Zfish   399 ERLDHLAEKFRQKAAIHEGWTDGKEAMLTQKDY--ETASLSEIKALLKKHEAFESDL----AAHQ 457

  Fly   376 DNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPEDHISPRKENKIFSNTESCSKQEGVLPKQ 440
            |.:::..|:....:.|  :..::|......|...:..|.:....:|:    .||..:.|    ||
Zfish   458 DRVEQIAAIAQELNEL--DYYDSPSVNARCQKICEQWDALGSLTQNR----RESLERTE----KQ 512

  Fly   441 MDLESPKDKVIETKASETDYPEDLNPFK-------DD----------DSSKG--------ANPFD 480
              |||..:..:|       |.:...||.       :|          |..:|        .:...
Zfish   513 --LESIDELYLE-------YAKRAAPFNNWMEGAMEDLQDMFIVHNIDEIQGLITAHEQFKSTLP 568

  Fly   481 SSDDEVELLKAIPAQQSK-----GKVVPPRPPPPKIGLSSISNPSEK-----PHSSPTLSH---- 531
            .::.|.|.::||.|:..|     |..:....|...|...||....||     |.....|..
Zfish   569 EANKEREAIQAIQAEVQKIANYNGIKLAGNNPYTTITPQSIDKKWEKVQQLVPQRDQALQEELTR 633

  Fly   532 -----------GKKMPMPTP----------RISISKTQTPAKPMTHQGQ--------KSSISSSS 567
                       ..:..|..|          ||||....|....:||..|        |.:|....
Zfish   634 QQSNDHLRRQFANQANMIGPWIQNKMEEIGRISIEMNGTLEDQLTHLSQYEQSIIEYKPNIDQLE 698

  Fly   568 SEH--LNSIRTFDRGADDRGSSISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSITSPMRKKR 630
            .:|  :.....|    |::.::.::.......:.|..::...:...|:      ..:|...:...
Zfish   699 GDHQLIQEALIF----DNKYTAYTMEHLRVGWEQLLTTIARTINEIEN------QVLTRDAKGIS 753

  Fly   631 QAPLPPIQTD---FDSDPGFSKLSDEQKALL--------HTQLKAPNLGDS---TRRLIPLDQSL 681
            |..|...:|.   ||.|......|:|.||.|        :.:.|...:.||   ...||....||
Zfish   754 QEQLHEYRTSFNHFDKDHSGLLQSEEFKACLISLGYDVENDKQKRTGIMDSDDFRALLISTGNSL 818

  Fly   682 ----------------------------LSDEATESSNYDESLST----------SNADEEVNVV 708
                                        :|.|.|::...|:.:::          ..|:|
Zfish   819 GDAEFARIMGIVDPNNSGAVTFQAFIDFMSRETTDTDTADQVIASFKILAGDKNYITAEE----- 878

  Fly   709 YRRILVPPTQPENTVER 725
            .||.| ||.|.|..:.|
Zfish   879 LRREL-PPDQAEYCIAR 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	48/100 (48%)
		LIM_like_1	146..207	CDD:188784	5/60 (8%)
		PTZ00449	<411..727	CDD:185628	82/437 (19%)
		bMERB_dom	785..933	CDD:463467
actn4	XP_021337011.1	CH_ACTN_rpt1	37..141	CDD:409063
		CH_ACTN_rpt2	145..259	CDD:409065	48/101 (48%)
		Spectrin	283..393	CDD:395348	22/122 (18%)
		SPEC	404..631	CDD:238103	49/251 (20%)
		Spectrin	639..742	CDD:395348	16/106 (15%)
		PTZ00184	749..>880	CDD:185504	24/135 (18%)
		EFhand_Ca_insen	853..919	CDD:430177	11/48 (23%)