Protein Alignment MICAL-like and Actn

DIOPT Version :10

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Alignment Length: 1026
• Identity: 205/1026 - (19%)
• Similarity: 341/1026 - (33%)
• Gaps: 409/1026 - (39%)

  Fly    11 TGTKALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAF 75
            |..:.|..||:..|..|..|.|:|...|:::||||||:||..||||||:.:|..|:..||.:.||
  Fly   148 TAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAF 212

  Fly    76 TTAEKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLGKSLKHPKPEEPLGEESEPPQKVMH 140
            ..|||||.||.:||..|:::...||..:|:||:|.:|...                 :..|:|.:
  Fly   213 DVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAF-----------------QGAQQVGN 260

  Fly   141 IVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPD 205
            :..:|.         |.          |.|                     |.|.|.|..||..:
  Fly   261 VTHVPE---------PT----------RQY---------------------TYVPNNYNAETAAN 285

  Fly   206 EESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQ 270
            ...:    :||:     :..|::.|       .|.|....||.:...||       .|..|..:.
  Fly   286 RICK----VLKV-----NQENERLM-------EEYERLASDLLEWIRRT-------MPWLNSRQA 327

  Fly   271 NNELTINPVNPILSEERKISFIPLDEEDGGLIEQYNKSTTPVKPAIPEKPKVSTLPLDDEQHAGV 335
            :|.|.        ..::|             :|:|.......||     |:|       ||.|.:
  Fly   328 DNSLA--------GVQKK-------------LEEYRTYRRKHKP-----PRV-------EQKAKL 359

  Fly   336 EQN-NDLAVSPENDIPKEKLKISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQEAP 399
            |.| |.|         :.||::|:...||..:...|..|           :|:...|
  Fly   360 ETNFNTL---------QTKLRLSNRPAYLPTEGKTVSDI-----------SNSWKGL-------- 396

  Fly   400 IPENNTQVAIKPEDHISPRKENKIFSNTESCSKQEGVLPKQMDLESPKDKVIETKASETDYPEDL 464
                  ::|            .|.|        :|.:|.:.|.||.     :|..|.:..:..|.
  Fly   397 ------ELA------------EKAF--------EEWLLAETMRLER-----LEHLAQKFKHKADA 430

  Fly   465 NPFKDDDSSKGANPFDSSDD----EVELLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKPHS 525
            :    :|.::|......|.|    ::..|||:                            :|.|.
  Fly   431 H----EDWTRGKEEMLQSQDFRQCKLNELKAL----------------------------KKKHE 463

  Fly   526 SPTLSHGKKMPMPTPRISISKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFD---------RGA 581
            :                      ..:....||.:...|::.:.| ||::...|         |..
  Fly   464 A----------------------FESDLAAHQDRVEQIAAIAQE-LNTLEYHDCVSVNARCQRIC 505

  Fly   582 D--DRGSSISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSITSPMRKKRQAP----LPPIQTD 640
            |  ||..:::        :..|.::....|..|......|..      .||.||    |...:.|
  Fly   506 DQWDRLGALT--------QRRRTALDEAERILEKIDILHLEF------AKRAAPFNNWLDGTRED 556

  Fly   641 FDSDPGFSKLSDEQKALL--HTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNADE 703
            . .|.......:|.:.|:  |.|.|| .||:                               ||:
  Fly   557 L-VDMFIVHTMEEIQGLIQAHDQFKA-TLGE-------------------------------ADK 588

  Fly   704 EVNVVYRRILVPPTQPENTVERSK-----EDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPA 763
            |.|::...:    .:.|:.|::.:     |:..:.:..||..|             ||.
  Fly   589 EFNLIVNLV----REVESIVKQHQIPGGLENPYTTLTANDMTR-------------KWS------ 630

  Fly   764 PAVPIPPRKVLQRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRC-------ERSLDATDTD 821
                    .|.|.:|.::     :.:| .:|..::...:|.:...::.       ||.:||....
  Fly   631 --------DVRQLVPQRD-----QTLA-NELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAI 681

  Fly   822 GPESAEVLTNSKEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHE-------- 878
            |      :.....:||   ||..|...:..::..:..:..|.:.|:..||....|:.
  Fly   682 G------MGLQGSLED---QLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMET 737

  Fly   879 IRVLMGQPEHNKTDSDKAHEEVL--INRLVKVVEMRNEVI--DS--LETDRVREAREDMS--IKN 935
            :||              ..|::|  |||.:..||  |:::  ||  :..:::.|.|...:  .||
  Fly   738 LRV--------------GWEQLLTSINRNINEVE--NQILTRDSKGISQEQLNEFRSSFNHFDKN 786

  Fly   936 RLHIYNSEREEPPAHPRSADKSSKKLSKKERKK--LKEENKLGKGKKSDLD 984
            |                     :.:||.:|.|.  :.....:||.::.|||
  Fly   787 R---------------------TGRLSPEEFKSCLVSLGYSIGKDRQGDLD 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	47/103 (46%)
		LIM_like_1	146..207	CDD:188784	9/60 (15%)
		PTZ00449	<411..727	CDD:185628	55/336 (16%)
		bMERB_dom	785..933	CDD:463467	32/170 (19%)
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063
		CH_ACTN_rpt2	139..252	CDD:409065	47/103 (46%)
		SPEC	302..525	CDD:238103	65/384 (17%)
		SPEC	420..647	CDD:238103	57/365 (16%)
		SPEC	538..760	CDD:238103	58/322 (18%)
		EFh	775..842	CDD:238008	14/63 (22%)
		EFhand_Ca_insen	847..913	CDD:430177