DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICAL-like and Micall1

DIOPT Version :9

Sequence 1:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster
Sequence 2:	XP_036015335.1	Gene:	Micall1 / 27008	MGIID:	105870	Length:	887	Species:	Mus musculus

Alignment Length:	1059	Identity:	290/1059 - (27%)
Similarity:	434/1059 - (40%)	Gaps:	250/1059 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDRRGTKVGTGTKALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKAD 65
            |:..||        ||..|||...:||.||.:.::::|:|:|||||||:|..||||:||..|..:
Mouse     1 MAGPRG--------ALLAWCRRQCEGYRGVDIRDLSSSFRDGLAFCAILHRHRPDLLDFQSLSKE 57

  Fly    66 DIYENNDLAFTTAEKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVL-------------GK 117
            :::|||.|||..|||.||||||||..||||..|||.|||:||:||:|...             ||
Mouse    58 NVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFTSSGQAAASPPKPGK 122

  Fly   118 SLKHPKP----------EEPLGEESEPPQKVMHIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHR 172
            ....|.|          ||..|::..|..........|....|..|...|.|.:|.|...|.|||
Mouse   123 DPAPPSPTSTSPAVQPGEEAQGDDLSPDSLSEQGKQQPPSSACAACGQRVHLVQRYLAEGRLYHR 187

  Fly   173 TCLKCARCSSLLTPGSFYE-TEVNNIYCCETCPDEESEPESDILKLKTTTTDSPNDK---QMVAQ 233
            .|.:|.:|||.|.|||:.. .|.....|.|.|                 |...|..:   ::::|
Mouse   188 HCFRCRQCSSTLVPGSYSSGPEEGTFVCAERC-----------------TRLGPGSRSGTRLLSQ 235

  Fly   234 SSDYSEAEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEERKISFIPLDEED 298
            ......|.: .:|.||||            ||                       :|...:.|.|
Mouse   236 QRQQPAAAE-AKDAEDND------------PS-----------------------LSVAAVAEAD 264

  Fly   299 GGLIEQYNKSTTPVKPAIPEKP-KVSTLPLDDEQHAGVEQNNDLAVSPENDIPKEKLK-----IS 357
            ........:..||.||.:|.|| ::::.|......|..:.:...|::|....|:..|:     ..
Mouse   265 RLQASSEVQFHTPTKPPLPSKPQELASPPGGRPTPAPRKASESSALTPPTPRPRSSLQQDGTVEQ 329

  Fly   358 SVSIYLEDDRLVVDAI-HPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPEDHISPRKEN 421
            |||..|.:.||....: .|....|.....|     :|..:..|:|...:::|       :|||:.
Mouse   330 SVSSGLVNGRLQEPPVPKPRGTPKLSERPN-----LPRGKADPLPWPPSRMA-------APRKDP 382

  Fly   422 KIFSNTESCSKQE--------GVLPKQMDLESPKDKVIE---TKASETD-YPEDLNPFKDDDSSK 474
            ...:..::..|::        |..|........:|..:|   .|:|.|: .|:..|||::::..:
Mouse   383 PWITLVQTEPKKKPAPQPPSSGPGPLSQAYRQVEDGGLEEQTQKSSGTEPEPKPYNPFEEEEEEE 447

  Fly   475 G--ANPFDSSDDEVELLKAIPAQQSKGKVVPPRPPP---------PKIGLSSISNPSEK------ 522
            |  |.|..|.    .|...:|:......|..|.|.|         |..|::..|:|..|
Mouse   448 GEPAPPVPSP----SLAPPVPSPSPAPPVPSPAPAPSEATPKSLHPWYGITPTSSPKTKKRPAPR 508

  Fly   523 -PHSSPTLSHGKKMPMPTPRISISKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRGS 586
             |.:||...|..::....|.   |.|.:||..:      .|:||.||.|..:....:..|..:.|
Mouse   509 APSASPLAIHASRLSHSEPP---SATPSPALSV------ESLSSESSSHTANAEPLEPPAVPKSS 564

  Fly   587 SISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSITSPMRKKRQAPLPPIQTDFDSDPGFSKLS 651
            |.  |:.:.|                .:|.||.:|:|           |...:...|.....:.|
Mouse   565 SD--PAVHVP----------------GTPGTSGNSVT-----------PSANSSLSSSGELGQPS 600

  Fly   652 DEQKALLHTQLKAPNLGDSTRRL---IPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYRRIL 713
            .||  :|..:.|......||:..   .|....|..|.              |....|.....::.
Mouse   601 GEQ--MLQARTKGSAGTHSTKPFSGATPTPFLLAGDR--------------NPAPPVGSASPQLQ 649

  Fly   714 VPPTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPAP--AVPIPPRKVL-- 774
            :..:..||...|......||.|             .|:|.|. |..:.|||  ..|:..|||.
Mouse   650 IKSSCKENPFNRKPSPSASPTV-------------RKATKGA-KPVRPPAPGHGFPLIKRKVQAD 700

  Fly   775 QRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTDGPESAEVLTNSKEVEDLI 839
            |.:|.::|..|.:.|..|...||..||:||:.:|...        .:|.|           :|::
Mouse   701 QYIPEEDIYGEMDNIERQLDALEHSGVLLEEKLRGGA--------NEGSE-----------DDML 746

  Fly   840 LQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAHEEVLINR 904
            :..|:|::||:.|.||::||:|:.:|..|||.|||:|.|:|.|:.:||.:.||.|:|.|:||:..
Mouse   747 VDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEFELRCLLNKPEKDWTDEDRAREKVLMQE 811

  Fly   905 LVKVVEMRNEVIDSLETDRVREAREDMSIKNRLHIYNSEREEPPAHPRSADKSSKKLSK-KERKK 968
            |:.::|.|:.:::.|:.||.||..||..::..:...:.:||        |:..|||..| |..|.
Mouse   812 LMTLIEQRDAIVNCLDEDRQREEEEDKMLETMIKKKDFQRE--------AESDSKKKGKFKTIKV 868

  Fly   969 LK------EENKLGKGKKS 981
            ||      |......|.||
Mouse   869 LKFLGNKREAKSKAPGDKS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	56/96 (58%)
		LIM_like_1	146..207	CDD:188784	23/61 (38%)
		DUF3585	778..933	CDD:288945	55/154 (36%)
Micall1	XP_036015335.1	CH_MICALL1	4..110	CDD:409101	60/113 (53%)
		LIM_Mical_like_1	165..219	CDD:188828	22/53 (42%)
		PHA03247	<287..686	CDD:223021	99/482 (21%)
		DUF3585	708..830	CDD:403377	48/140 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849586
Domainoid	1	1.000	139	1.000	Domainoid score	I4772
eggNOG	1	0.900	-	-		E2759_2QWQX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47674
OrthoDB	1	1.010	-	-		D186776at33208
OrthoFinder	1	1.000	-	-		FOG0002858
OrthoInspector	1	1.000	-	-		otm42521
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5658
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.800