Protein Alignment MICAL-like and EHBP1

DIOPT Version :10

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: NP_056067.2
• Gene: EHBP1 / 23301
• HGNCID: 29144
• Length: 1231
• Species: Homo sapiens
• Alignment Length: 1037
• Identity: 229/1037 - (22%)
• Similarity: 386/1037 - (37%)
• Gaps: 337/1037 - (32%)

  Fly    13 TKALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTT 77
            :::|..||:.||:.|.|||:.|.||||||||:||||:|||||||||:..|...||.|||..|:..
Human   446 SQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDG 510

  Fly    78 AEKYLGIPALLDAADMVSYEVPDRLSILTYLSQF----------------------YKV------ 114
            ... :||..||:.:|||...:||:|:::|||.|.                      |||
Human   511 FAS-IGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETD 574

  Fly   115 LGKSLKHPKPEEPLGE---ESEPPQKVMHIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLK 176
            ...|:...|....|.:   |.|..|.:...|....:|.      .||:.:..:....:.|:
Human   575 TNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDD------SVFVNDSGVGESESEHQ---- 629

  Fly   177 CARCSSLLTPGSFYETEVNNIYCCETCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAE 241
                    ||.........:.||..|..|.|.: :|.....:|:.:|.|.    :..::|.::|:
Human   630 --------TPDDHLSPSTASPYCRRTKSDTEPQ-KSQQSSGRTSGSDDPG----ICSNTDSTQAQ 681

  Fly   242 D--------KQEDLEDNDIRTTDKPENFQPP---SNKDEQNNELTINPVNPILSEERKISFIPLD 295
            .        |.|.||.:|:..:||.::..||   ...|||  :|....:...|.:|:.
Human   682 VLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQ--KLQTLDIGSNLEKEKL------- 737

  Fly   296 EEDGGLIEQYNKSTTPVKPAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPENDIPKEKLKISSVS 360
             |:...:|..:...:|:|       |.|..|           .:.|..|...|:...|.|.:|:.
Human   738 -ENSRSLECRSDPESPIK-------KTSLSP-----------TSKLGYSYSRDLDLAKKKHASLR 783

  Fly   361 IYLED---DRLVVDAIHPDN---------LDKQEALNNTSDALIPESQEAPIPENNTQVAIKPED 413
            ....|   ||..::  |.|:         |.:||.|...:..|:.:::.        ..|:|
Human   784 QTESDPDADRTTLN--HADHSSKIVQHRLLSRQEELKERARVLLEQARR--------DAALK--- 835

  Fly   414 HISPRKENKIFSNTES--CSKQEGVLPKQMD-------LESPKDKVIE----TKASETDYPEDLN 465
                 ..||..:||.:  |::|   |..|.|       .|..:..:.|    .|.||.....::.
Human   836 -----AGNKHNTNTATPFCNRQ---LSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMA 892

  Fly   466 PFKDDDSSKGANPFDSSDD-EVELLKAIPAQQSKGKVVPPRPPPPKIG----LSSISNPSEKPHS 525
            ..|..:.||.:.  |.:|: |::..:.||    :|.||         |    |:::.|..:.|..
Human   893 AEKLKERSKASG--DENDNIEIDTNEEIP----EGFVV---------GGGDELTNLENDLDTPEQ 942

  Fly   526 SPTL--SHGKKMPMPTPRISISKTQTPAKPMT---HQGQKSSISSSSSEHLNSIRTFDRGADDRG 585
            :..|  ...||:....|:::.|.:....|.:|   .|..||......:|.|.  :|.:|.
Human   943 NSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQ--KTTERF----- 1000

  Fly   586 SSISLPSANGPRKPLRASVGSPLRSEESSPTTSLSSITS-----PMRKKRQAPLPPIQTDFDSDP 645
                       |.|:..|..|.:|.      |.|.|.:.     |..|::::    ||.|
Human  1001 -----------RNPVVFSKDSTVRK------TQLQSFSQYIENRPEMKRQRS----IQED----- 1039

  Fly   646 GFSKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYR 710
             ..|.::|:.|:..||.|            |.:..:|:....::|.|
Human  1040 -TKKGNEEKAAITETQRK------------PSEDEVLNKGFKDTSQY------------------ 1073

  Fly   711 RILVPPTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPAPAVPIPPRKVLQ 775
                                                                             
Human  1074 ----------------------------------------------------------------- 1073

  Fly   776 RLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTDGPESAEVLTNSKEVEDLIL 840
                  :..|...:..:|..::.:..::||.:|       ...||.        .|::|.|.::.
Human  1074 ------VVGELAALENEQKQIDTRAALVEKRLR-------YLMDTG--------RNTEEEEAMMQ 1117

  Fly   841 QLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAHEEVLINRL 905
            :.|.|||:||.|.||..:|..|.::|.||:....:..|:|.::...:..||::.|..|::|::.|
Human  1118 EWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDEL 1182

  Fly   906 VKVVEMRNEVIDSLETDRVREAREDMSIKNRLHIYNSEREEPPAHPRSADKSSKKLSKKERK 967
            |.:|..|:.::..|:....:...||..::                 |:.:::..|::|||.|
Human  1183 VALVNKRDALVRDLDAQEKQAEEEDEHLE-----------------RTLEQNKGKMAKKEEK 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	55/129 (43%)
		LIM_like_1	146..207	CDD:188784	10/60 (17%)
		PTZ00449	<411..727	CDD:185628	66/343 (19%)
		bMERB_dom	785..933	CDD:463467	38/147 (26%)
EHBP1	NP_056067.2	NT-C2	12..165	CDD:463058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..318
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..440
		CH_EHBP1	444..550	CDD:409103	52/104 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..675		12/75 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..764		7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..800		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..865		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..941		14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..996		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1025..1065		13/61 (21%)
		bMERB_dom	1077..1210	CDD:463467	38/147 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1198..1231		8/47 (17%)
		CAAX motif. /evidence=ECO:0000305|PubMed:27552051	1228..1231		229/1037 (22%)