DRSC/TRiP Functional Genomics Resources

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Protein Alignment MICAL-like and Actn2

DIOPT Version :10

Sequence 1:NP_648621.1 Gene:MICAL-like / 39475 FlyBaseID:FBgn0036333 Length:1010 Species:Drosophila melanogaster
Sequence 2:NP_150371.4 Gene:Actn2 / 11472 MGIID:109192 Length:894 Species:Mus musculus


Alignment Length:836 Identity:164/836 - (19%)
Similarity:278/836 - (33%) Gaps:277/836 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            :.|..||:..|..|..|.::|..|||::||..||:||..||||||:.:|..||...|.:||...|
Mouse   155 EGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIA 219

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLG-------------KSLKHPKPEEPLGE 130
            ||:|.||.:|||.|:|:...||..:|:||:|.||....             |.|...:..|.|.|
Mouse   220 EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLME 284

  Fly   131 ESE--------------------PPQKVMHIVGMPRRD---------------KCQK-------- 152
            |.|                    .|:|.|..:.....|               |||.        
Mouse   285 EYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQ 349

  Fly   153 -----CNLPVFLA-------------ERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYC 199
                 .|.|.|:.             :|:...::.|....|                .|:..:  
Mouse   350 TKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLL----------------NEIRRL-- 396

  Fly   200 CETCPDEESEPESDILKLKTTTTDS-PNDKQMVAQSSDYSEAE--------DKQEDLEDNDIRTT 255
                  |..|..::..:.|.:|.:: ...|:.:....||..|.        .|.|..|.:.....
Mouse   397 ------ERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQ 455

  Fly   256 DKPENFQPPSNKDEQNNELTINPVNPILSEERKISFIPLDEED--GGL-------IEQYNKSTTP 311
            |:.|.....:   ::.|||..:....:....:||    .|:.|  |.|       :|:..|....
Mouse   456 DRVEQIAAIA---QELNELDYHDAVNVNDRCQKI----CDQWDRLGTLTQKRREALERTEKLLET 513

  Fly   312 VKPAIPEKPKVSTLPLDDEQHAGVEQNNDL--------------------AVSPENDIPKEKLKI 356
            :.....|..| ...|.::.....:|...|:                    |..||.|..::    
Mouse   514 IDQLHLEFAK-RAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ---- 573

  Fly   357 SSVSIYLEDDRLV------VDAIHPDNLDKQEALNNTSDALIPESQEAPIPENNTQVAIKPE--- 412
            |.::|..|.::::      :.:.:|.:....:.|.|..|.:   .|..|:.:.:.|..:..:   
Mouse   574 SILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKV---KQLVPVRDQSLQEELARQHAN 635

  Fly   413 -----------DHISPRKENKIFSNTESCSKQEGVLPKQMD-LESPKDKVIETKASETDYPEDLN 465
                       :.|.|..:||:.....|..:..|.|..||: |:..:..:|..|           
Mouse   636 ERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK----------- 689

  Fly   466 PFKDDDSSKGANPFDSSDDEVELLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKPHSSPTLS 530
                       |..|..:.:.:|::......:|                         |::.|:.
Mouse   690 -----------NNIDKLEGDHQLIQEALVFDNK-------------------------HTNYTME 718

  Fly   531 H---GKKMPMPTPRISISKTQT-----PAKPMTHQGQKSSISSSSSEHLNSIRT----FDR---- 579
            |   |.::.:.|...:|::.:|     .||.:|            .|.:|..|.    |||    
Mouse   719 HIRVGWELLLTTIARTINEVETQILTRDAKGIT------------QEQMNEFRASFNHFDRRKNG 771

  Fly   580 ---GADDRGSSISLPSANGPRKPLR-ASVGSP-------------LRSEESSPTTSLSSITSPMR 627
               ..|.|...||:....|..:..| .::..|             ..:.|::.|.:...:.:..|
Mouse   772 LMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFR 836

  Fly   628 -----------KKRQAPLPPIQTDF--DSDPGFSKLSDEQKALLHTQLKAPNLGDS 670
                       ::.:..|||.|..:  ...|.:|.......||.:|...:...|:|
Mouse   837 ILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGES 892

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MICAL-likeNP_648621.1 CH_MICALL2 11..115 CDD:409102 47/100 (47%)
LIM_like_1 146..207 CDD:188784 11/101 (11%)
PTZ00449 <411..727 CDD:185628 53/321 (17%)
bMERB_dom 785..933 CDD:463467
Actn2NP_150371.4 Actin-binding 1..254 46/98 (47%)
CH_ACTN_rpt1 35..139 CDD:409063
CH_ACTN_rpt2 143..257 CDD:409065 47/101 (47%)
Spectrin 1 281..391 17/125 (14%)
Spectrin 281..391 CDD:395348 17/125 (14%)
Spectrin 2 401..506 20/111 (18%)
SPEC 402..629 CDD:238103 41/241 (17%)
Spectrin 3 516..627 18/118 (15%)
Spectrin 4 637..740 22/149 (15%)
Spectrin 637..739 CDD:395348 22/148 (15%)
PTZ00184 747..>851 CDD:185504 19/115 (17%)
EFhand_Ca_insen 824..890 CDD:430177 11/65 (17%)
Blue background indicates that the domain is not in the aligned region.

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