Protein Alignment MICAL-like and micall1a

DIOPT Version :9

• Sequence 1: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_001922175.2
• Gene: micall1a / 100149741
• ZFINID: ZDB-GENE-110119-1
• Length: 867
• Species: Danio rerio
• Alignment Length: 1057
• Identity: 292/1057 - (27%)
• Similarity: 429/1057 - (40%)
• Gaps: 302/1057 - (28%)

  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78
            |||:.|||.....||.|.:.|||:|:|:|||||||||..||||||||.|..::::|||.|||..|
Zfish     5 KALQDWCRNQCASYNNVDITNMTSSFRDGLAFCAIIHRHRPDLIDFDSLSKENVFENNRLAFEVA 69

  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYK-------VLGKSLKHPKP--------EEPL 128
            |:.|||||||||.||||..|||||||:||:||:|.       .:.|.:|.|..        :.||
Zfish    70 ERELGIPALLDAEDMVSMSVPDRLSIITYVSQYYNFFTNKSHTVSKCIKSPSSSGYIRSAIKRPL 134

  Fly   129 GEESEPPQKVMHIVG----MPRR----DKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLT 185
               :.|..:..|...    .|:|    ..|..|...|.|.:|:||..:.|||.|.:|..||..|.
Zfish   135 ---ASPEDRDAHNESGADIQPKRSTLSSTCSACGKHVHLVQRILVDGKLYHRNCFRCRECSRTLL 196

  Fly   186 PGSFYETEVNNIYCC--------ETCPDEESEPESDILKLKTTTTDSP---NDKQMVAQSSDYSE 239
            |||:..||......|        .|..:..|:..:.:.|| ||:.:.|   ||.::..|..
Zfish   197 PGSYKFTEDPGALVCTHHFTRSASTNQNGHSDMSNRLAKL-TTSAEDPLCGNDSEISPQRD---- 256

  Fly   240 AEDKQEDLEDNDIRTTDKPENFQPPSNKDEQNNELTINPVNPILSEERKISFIPL----DEEDGG 300
             |:|..:||:...:.||         :|.:...|...||.:....|:|.|....|    |..:|.
Zfish   257 -EEKTSELEERLRKQTD---------SKSKVETEEGANPFDESEEEDRDIQQEDLKSATDVANGD 311

  Fly   301 LIEQYNKSTTPVKPAIPE-----KPKVSTLPLDDEQHAGVEQ------NNDLAVSPENDIPKEKL 354
            ......|||......:|.     :|..:..|:...:.:.:.:      :.|...:|:..:|||::
Zfish   312 TPSTSVKSTAAESRPVPAPRRVLEPSPAPRPVPRLRRSRISESITVNGDPDQTQTPQVPVPKERM 376

  Fly   355 KISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSD----ALI-PESQEAPIPENNTQVAIKPEDH 414
            ...:        |...|...|            .|    ||: .|::..|.|...|..|:.|...
Zfish   377 HSPA--------RKAGDTPKP------------KDPPWLALVQSETKRKPAPRPPTGTAVPPSTG 421

  Fly   415 ISP-RKENKIFSNTESCSKQEGVLPKQMDLESPKDKVIETKASETDYPEDLNPFKDDDSSKGANP 478
            .|| |||                                    ||..|           |...||
Zfish   422 ASPSRKE------------------------------------ETSRP-----------STPPNP 439

  Fly   479 FDSSDDEVELLKAIPAQQSKGKVVPPRPPPPKIGLSSISNPSEKP-----------HSSPTLSHG 532
            |::.::|.|  ..:..:...|.||...|      ...|::.:|.|           ..||.....
Zfish   440 FENEEEEEE--SELGPEDVPGPVVASHP------WYGITHSTEVPGGDAGKQSPARSESPISIRR 496

  Fly   533 KKMPMP------TPRISISKTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRG----SS 587
            ||.|.|      |.....|:|.:||..:....:  |:|||||::  |.......|:::.    .|
Zfish   497 KKRPAPKAPNSSTSAFPSSQTSSPASSLALSTE--SLSSSSSDY--SAVPQKAAANEQDHLFTKS 557

  Fly   588 ISLPSANGPRKPLRASVG-----SPLRSEESSPTTSLSSITSPMRKKRQAPLPPIQTDFDSDPGF 647
            :|.||.|.|...|.....     ||..|....|.|:.||          ||..| ||:..:.|
Zfish   558 VSEPSINTPASALSQKAELQPRCSPNLSPPPPPPTNTSS----------APATP-QTNRSARP-- 609

  Fly   648 SKLSDEQKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYRRI 712
                             |:| .:..::.|..|:
Zfish   610 -----------------PSL-SAGLKITPTSQT-------------------------------- 624

  Fly   713 LVPPTQPENTVERSKEDQKSPIVYNDFDRNVSPLGHNKSTHGKWKRRKGPAPAVPIPP------- 770
              |.|..:.|.:.:..::|:....|.|   ||            :..|||.||.|..|
Zfish   625 --PGTPGKRTCKENPFNRKTTTSANSF---VS------------RPPKGPRPARPPAPGHGFPLI 672

  Fly   771 -RKVL--QRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIRDRCERSLDATDTDGPESAEVLTNS 832
             |||.  |.:|:::|..|...:..:...||.:||.|||.:|: |                  :|.
Zfish   673 KRKVQSDQFIPVEDIHVEMSDLEKRLDELEHRGVDLEKSLRE-C------------------SND 718

  Fly   833 KEVEDLILQLFELVNEKNELFRRQAELMYLRRQHRLEQEQADIEHEIRVLMGQPEHNKTDSDKAH 897
            :|.|.|::..|.|::||:.|.||:|||:|..:|..||:.|||:|:|:|.|:.:||...|..||..
Zfish   719 EEEEHLLVDWFTLIHEKHLLVRREAELVYTAKQQNLEERQADVEYELRCLLNKPEKEWTSEDKDR 783

  Fly   898 EEVLINRLVKVVEMRNEVIDSLETDRVREARED-----MSIKNRLHIYNSEREEPPAHPRSADKS 957
            |:.|:..||.::|.||:::::::.||.||..||     |..|...|....:::          ||
Zfish   784 EKQLMADLVTIIEQRNQIVNNIDIDRQREEEEDKLVAAMLKKKDFHGQGEQKK----------KS 838

  Fly   958 SKKLSKKERKKLKEENK 974
            .|....|..|:|..:|:
Zfish   839 GKFKPMKVLKRLSTKNE 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICAL-like	NP_648621.1	CH	14..111	CDD:278723	63/96 (66%)
		LIM_like_1	146..207	CDD:188784	23/72 (32%)
		DUF3585	778..933	CDD:288945	56/159 (35%)
micall1a	XP_001922175.2	CH	5..102	CDD:278723	63/96 (66%)
		LIM_Mical_like_1	161..215	CDD:188828	21/53 (40%)
		DUF3585	683..819	CDD:288945	55/154 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595326
Domainoid	1	1.000	142	1.000	Domainoid score	I4623
eggNOG	1	0.900	-	-		E2759_2QWQX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2900
OMA	1	1.010	-	-		QHG47674
OrthoDB	1	1.010	-	-		D186776at33208
OrthoFinder	1	1.000	-	-		FOG0002858
OrthoInspector	1	1.000	-	-		otm25641
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5658
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.800