DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CDC53

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_010150.1	Gene:	CDC53 / 851424	SGDID:	S000002290	Length:	815	Species:	Saccharomyces cerevisiae

Alignment Length:	822	Identity:	168/822 - (20%)
Similarity:	315/822 - (38%)	Gaps:	205/822 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VNQIFDD-----------YTSFDGQKLMHLYHLIYKQCAAERNWN---NPAQKNGRSLYIVLSDC 75
            :|||..:           |........|.:|..||..|..:...:   :...:.|:|..:|.|:
Yeast    22 INQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHFSTDSRTGQSTILVGSE- 85

  Fly    76 LMKRLKNIAWVMENQLDDNKPIR---LIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGD 137
            :.::|||   .::|.:.:.|...   .:..|::.|..:......||.|..:.||.||::||..|.
Yeast    86 IYEKLKN---YLKNYILNFKQSNSETFLQFYVKRWKRFTIGAIFLNHAFDYMNRYWVQKERSDGK 147

  Fly   138 KETYPIYRLAMISWKELVFEPSVTILAAIRLILSQM---------------------------PR 175
            :..:.:..|.:::|||::|:||..:|  |..:|.|:                           |:
Yeast   148 RHIFDVNTLCLMTWKEVMFDPSKDVL--INELLDQVTLGREGQIIQRSNISTAIKSLVALGIDPQ 210

  Fly   176 EYNKSLEYQVY-QVL--------QSIVELYANDKYQDVSLPSRIDKIF-----TEKVMDFY---- 222
            :. |.|...|| ||.        |.....|.||..:..|:...|.:..     .||.|..|
Yeast   211 DL-KKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDH 274

  Fly   223 -KSTTLHEFQKIVVSNDYKDFKH-FLRYACLAMPEIENGTQFKAILKR--------------YL- 270
             |........|:::::..:..:: |:  ..|...:||..|...|:::|              |:
Yeast   275 TKKPLSMALNKVLITDHIEKLENEFV--VLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVK 337

  Fly   271 ----------------------------AARLQETRLSGKDYIQAFL---GLCRGPLQRALRDHT 304
                                        .|.:....||.||||:..|   .:.......:..|..
Yeast   338 KTGENEISSLLAMHKHNIMKNENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDI 402

  Fly   305 KLAEVVDAVCKEEIN----------RKGQIIDPTRLLVTYANELMTKRQESEEAIIDELKRIVKC 359
            .||:.:|..|...||          .|......:.:|..|::.|:.|..:.|.|.....:.|:..
Yeast   403 PLAKALDNACGAFININEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDIITI 467

  Fly   360 VEFLSDEYKFIDMYLKALRIRQINETSTS-DGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRT 423
            .::|:|:..|...|.:....|.|:.|||| :..|:|:..|   :.||           .::....
Yeast   468 FKYLTDKDAFETHYRRLFAKRLIHGTSTSAEDEENIIQRL---QAAN-----------SMEYTGK 518

  Fly   424 LKKEFQDHLNSKGIKLGF----------------DFRPKCFKND---GSFENFNLTLPDELQQAW 469
            :.|.|||...||.::..|                |.:|.....:   .|::.....||.||..:.
Yeast   519 ITKMFQDIRLSKILEDDFAVALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSH 583

  Fly   470 KEFRIFYEARKLQSKAIIQLNNELSSGEITCHL---NQSVYILEVSTLQMAVLMLFNRHERFTEQ 531
            ::.:..|..:  .:..|::....|..||:...:   .:..:...|:..|||:|:|:|..:..|.:
Yeast   584 EKLKESYSQK--HNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLE 646

  Fly   532 ELVTALGVELETLQEALKQ-IKFLVYIEV-----------------NKVNYIEINMDFTNRKRRL 578
            .:.....:.::.:..|:.. |||.:..:|                 .....::.|::|.:..:
Yeast   647 NIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVK-- 709

  Fly   579 FCNEPLP-----------RKM--RKIEEKSEIELKIRRDKQV--DAAIVRIMKGQKQLEYSELIS 628
              |:.|.           .|:  :::.|...||.::..::|:  :|.||||||.::.|.::.|::
Yeast   710 --NDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLVN 772

  Fly   629 LVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNYYNIYRYL 670
            ....:...|...:||.:|:.:|.|:::.||:|.:....|.||
Yeast   773 ECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGESYAYL 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	166/820 (20%)
		CULLIN	362..500	CDD:214545	34/157 (22%)
		Cullin_Nedd8	606..661	CDD:287520	18/56 (32%)
CDC53	NP_010150.1	COG5647	7..815	CDD:227934	168/822 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1033
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.750