DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL3

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001244127.1	Gene:	CUL3 / 8452	HGNCID:	2553	Length:	774	Species:	Homo sapiens

Alignment Length:	818	Identity:	169/818 - (20%)
Similarity:	290/818 - (35%)	Gaps:	236/818 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:|:..|:.|.:|.:.:..:...||:     .||...|...         ..|:|..||..|.:
Human    35 YVNSIWDLLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLYTGLRE 85

  Fly    75 CLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            .:.:.|.| :...:.|.|::|    .:....:.|..:|.:...:.....:.:|.:|::..::.
Human    86 VVTEHLINKVREDVLNSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVEN-- 144

  Fly   139 ETYPIYRLAMISWKELVF---------------------EPSVTILAAIR------LILS----- 171
                :|.|.:|.:::.|.                     :..|....|||      :||.
Human   145 ----VYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRS 205

  Fly   172 -----------QMPREY-----NKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD 220
                       :|..|:     .|.|......|....||...|::.:.|.  ..:||...|.::.
Human   206 VYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCLDKSTEEPIVK 268

  Fly   221 FYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENGTQFKAILKRYLAARLQET 277
            ..:...:.:..|.:|..:.....|.|:      ..|:  ....:.||      ||..........
Human   269 VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNG------LKTMCECMSSYL 327

  Fly   278 RLSGK-------------DYIQAFLGL---------------------------------CRGPL 296
            |..||             ||||..|.|                                 .|.|.
Human   328 REQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNSRSPE 392

  Fly   297 QRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTYANELMTKRQESEEAIIDELKRIVKCVE 361
            ..:|....||.:.|..:.::|:                            |.|:|:...:.:
Human   393 YLSLFIDDKLKKGVKGLTEQEV----------------------------ETILDKAMVLFR--- 426

  Fly   362 FLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKK 426
            |:.::..|...|.:.|..|.:...|.||..|..|.|.|..:.....|..:....||:....|...
Human   427 FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMD 491

  Fly   427 EFQDHLNSKGIKL-GFDF---------------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIF 475
            ||:.||.:.|:.| |.|.               .|||            .:|...:.|::.||.|
Human   492 EFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKC------------NIPPAPRHAFEIFRRF 544

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHL----------------------NQSVYILEVSTLQMAV 518
            |.|:  .|...:.|.:.:.|.::....                      |...:||:|||.||.:
Human   545 YLAK--HSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTI 607

  Fly   519 LMLFNRHERFTEQELVTALGVELETLQEALKQI-----------KFLVYIEVNKVNYIEINMDFT 572
            |||||..|::|.:|:.....:....|..||:.:           |.....|:...:...:|..||
Human   608 LMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFT 672

  Fly   573 NRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELK 635
            ::..|:.......::.....|:.|...|:..|:  :::||||||||.:|:::::.|::.|.::||
Human   673 SKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLK 737

  Fly   636 DRVKPQVSFIKKRLDYLVEREYLER---DNYYNIYRYL 670
            .|..|....||||::.|:|||||.|   |.  .:|.|:
Human   738 ARFLPSPVVIKKRIEGLIEREYLARTPEDR--KVYTYV 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	163/801 (20%)
		CULLIN	362..500	CDD:214545	37/153 (24%)
		Cullin_Nedd8	606..661	CDD:287520	26/57 (46%)
CUL3	NP_001244127.1	Cullin	41..670	CDD:279260	131/705 (19%)
		CULLIN	427..569	CDD:214545	37/155 (24%)
		Cullin_Nedd8	706..766	CDD:287520	26/59 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820