DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL4A

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001008895.1	Gene:	CUL4A / 8451	HGNCID:	2554	Length:	759	Species:	Homo sapiens

Alignment Length:	759	Identity:	167/759 - (22%)
Similarity:	295/759 - (38%)	Gaps:	174/759 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNI------AWVME 88
            |:||....:||......:....:...|.....|.........:|..|.|:|:..      |.::.
Human    56 DNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP 120

  Fly    89 NQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP--------IYR 145
            .:.|....:..:.|....|..:.|....:.......:|.:|.:      ..|.|        ::|
Human   121 FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ------NSTLPSIWDMGLELFR 179

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQ-----MPREYNKSL-----EYQVY------QVLQSIVE 194
            ..:||.|.:   .|.||...:.||..:     :.|...:||     :.|||      :.|:....
Human   180 THIISDKMV---QSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNC 241

  Fly   195 LYAND---KYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEI 256
            |||.:   ..|:..:|..::.:  .|.::       .|..:::...|:...|..:  ||:....:
Human   242 LYAAEGQRLMQEREVPEYLNHV--SKRLE-------EEGDRVITYLDHSTQKPLI--ACVEKQLL 295

  Fly   257 ENGTQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRALRDH------------------ 303
              |....|||::.|...|.|.|:.....:.......||. |:||..|
Human   296 --GEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGG-QQALLQHWSEYIKTFGTAIVINPEK 357

  Fly   304 ------------TKLAEVVDAVCKEEINRKGQIIDPTRLLVTYAN-------ELMTKRQES---- 345
                        .|:..|:: ||.::..|...::..:  ..|:.|       ||:.|..:|
Human   358 DKDMVQDLLDFKDKVDHVIE-VCFQKNERFVNLMKES--FETFINKRPNKPAELIAKHVDSKLRA 419

  Fly   346 --EEAIIDELKR----IVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMA 404
              :||..:||:|    |:....|:..:..|...|.|.|..|.:...|.|...|..|.|.|..:..
Human   420 GNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG 484

  Fly   405 NFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKG-----------IKLGF--DFRPKCFKNDGSFEN 456
            ...|..:....:|::..:.:...|:.|:.::.           :.:|:  .:.|
Human   485 AAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTP----------- 538

  Fly   457 FNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILEVSTL 514
            ..:.|..|:.:..:.|:.||    ..||||.:..:   .|..|...|:..         .:||..
Human   539 MEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKE---------FQVSLF 594

  Fly   515 QMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------INMD 570
            |..||::||..:.|:.:|:..|.|:|...|:..|:.:   |..|.|:..|...:|      .|.:
Human   595 QTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGE 659

  Fly   571 FTNRKRRLFCNEPLPRKMRKIEEKSEIELKIR--------RDKQVDAAIVRIMKGQKQLEYSELI 627
            |.::..|:        |:.:|:.|..:|.::.        |..|:|||||||||.:|.|.::.|:
Human   660 FKHKLFRI--------KINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLV 716

  Fly   628 SLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            |.:|.:||..|||  ..:|||::.|::|:|:||| :..|.|.|:
Human   717 SELYNQLKFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYV 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	166/757 (22%)
		CULLIN	362..500	CDD:214545	30/157 (19%)
		Cullin_Nedd8	606..661	CDD:287520	27/54 (50%)
CUL4A	NP_001008895.1	Cullin	65..657	CDD:307166	124/637 (19%)
CUL4A	NP_001008895.1	Cullin_Nedd8	688..753	CDD:214883	30/66 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820