Protein Alignment Cul6 and CUL3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_174005.1
• Gene: CUL3 / 839226
• AraportID: AT1G26830
• Length: 732
• Species: Arabidopsis thaliana
• Alignment Length: 770
• Identity: 171/770 - (22%)
• Similarity: 312/770 - (40%)
• Gaps: 180/770 - (23%)

  Fly    24 VVNQIFDDYTSFDGQKLMHLYHLIYKQCAA-------ERN-WNNPAQKNGRSLYIVLSDCLMKRL 80
            ||:..:.|.|   .|.|....|.||.|.|:       .|| :|....|.|..||......:...|
plant    19 VVDPKYADKT---WQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGEKLYTGFIATMTSHL 80

  Fly    81 KNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYR 145
            |..:.::|.....:....|..|:.||    .::.|.:.....:.:|.::|     ..|:|: ::.
plant    81 KEKSKLIEAAQGGSFLEELNKKWNEH----NKALEMIRDILMYMDRTYIE-----STKKTH-VHP 135

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQMPRE-----YNKSLEYQVYQVLQSIVE-LYANDKYQDV 204
            :.:..|::.|...:......:..:|..:.:|     .::.|...|.::...:.| :|..|
plant   136 MGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGESVYQED----- 195

  Fly   205 SLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDF--KHFLRYACLAMPEIENGTQFKAILK 267
                 .:|.|.:...:|||.    |.|:.:.|.|..|:  |...|..    .|||.       :.
plant   196 -----FEKPFLDASSEFYKV----ESQEFIESCDCGDYLKKSEKRLT----EEIER-------VA 240

  Fly   268 RYLAARLQE--TRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIID---- 326
            .||.|:.:|  |.:..|:.|       ...:||.:  |.:.:.:|:.:..::....|::.:
plant   241 HYLDAKSEEKITSVVEKEMI-------ANHMQRLV--HMENSGLVNMLLNDKYEDLGRMYNLFRR 296

  Fly   327 PTRLLVTYANELMTK--RQESEEAIID--ELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETST 387
            .|..||| ..::||.  |:..::.:.|  :.|..|:.|:.|.||.   |.|.|.:.....|:.:.
plant   297 VTNGLVT-VRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDER---DKYDKIINTAFGNDKTF 357

  Fly   388 SDGVESIM--YSLLNKKMANFVTRCIYVQLR---------DV----DKLRTL----------KKE 427
            .:.:.|..  :..||.:...|::..:..:||         ||    ||:..|          :|.
plant   358 QNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKY 422

  Fly   428 FQDHL---------------NSKGIKL----GFDFRPKCFKNDGSFENFNLT------------- 460
            ::.||               .|..:||    |:.|..|.   :|.|.:...:
plant   423 YKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKL---EGMFTDMKTSEDTMRGFYGSHPE 484

  Fly   461 --------------------------LPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEIT 499
                                      ||.|:....::||.:|.......:...|.|  :.:.:|.
plant   485 LSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTN--MGTADIK 547

  Fly   500 CHLNQ-SVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI----------KF 553
            ....: ..:.|.|||.||.||||||..:|.:.:|:..|..:....|:..|:.:          |.
plant   548 AIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKNVIKKE 612

  Fly   554 LVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMK 616
            .:..::.:.:...:|..||::..::.....:.:|..: .||.|...::..|:  |::||||||||
plant   613 PMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETE-PEKQETRQRVEEDRKPQIEAAIVRIMK 676

  Fly   617 GQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            .:|.|:::.:|:.|.::|:.|.....:.||||::.|:||::||||:. ..:||||
plant   677 SRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYL 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	168/767 (22%)
CUL3	NP_174005.1	Cullin	29..630	CDD:459983	130/653 (20%)
		Cullin_Nedd8	662..724	CDD:463146	27/61 (44%)