DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL3

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_174005.1	Gene:	CUL3 / 839226	AraportID:	AT1G26830	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	770	Identity:	171/770 - (22%)
Similarity:	312/770 - (40%)	Gaps:	180/770 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VVNQIFDDYTSFDGQKLMHLYHLIYKQCAA-------ERN-WNNPAQKNGRSLYIVLSDCLMKRL 80
            ||:..:.|.|   .|.|....|.||.|.|:       .|| :|....|.|..||......:...|
plant    19 VVDPKYADKT---WQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGEKLYTGFIATMTSHL 80

  Fly    81 KNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYR 145
            |..:.::|.....:....|..|:.||    .::.|.:.....:.:|.::|     ..|:|: ::.
plant    81 KEKSKLIEAAQGGSFLEELNKKWNEH----NKALEMIRDILMYMDRTYIE-----STKKTH-VHP 135

  Fly   146 LAMISWKELVFEPSVTILAAIRLILSQMPRE-----YNKSLEYQVYQVLQSIVE-LYANDKYQDV 204
            :.:..|::.|...:......:..:|..:.:|     .::.|...|.::...:.| :|..|
plant   136 MGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGESVYQED----- 195

  Fly   205 SLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDF--KHFLRYACLAMPEIENGTQFKAILK 267
                 .:|.|.:...:|||.    |.|:.:.|.|..|:  |...|..    .|||.       :.
plant   196 -----FEKPFLDASSEFYKV----ESQEFIESCDCGDYLKKSEKRLT----EEIER-------VA 240

  Fly   268 RYLAARLQE--TRLSGKDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIID---- 326
            .||.|:.:|  |.:..|:.|       ...:||.:  |.:.:.:|:.:..::....|::.:
plant   241 HYLDAKSEEKITSVVEKEMI-------ANHMQRLV--HMENSGLVNMLLNDKYEDLGRMYNLFRR 296

  Fly   327 PTRLLVTYANELMTK--RQESEEAIID--ELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETST 387
            .|..||| ..::||.  |:..::.:.|  :.|..|:.|:.|.||.   |.|.|.:.....|:.:.
plant   297 VTNGLVT-VRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDER---DKYDKIINTAFGNDKTF 357

  Fly   388 SDGVESIM--YSLLNKKMANFVTRCIYVQLR---------DV----DKLRTL----------KKE 427
            .:.:.|..  :..||.:...|::..:..:||         ||    ||:..|          :|.
plant   358 QNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKY 422

  Fly   428 FQDHL---------------NSKGIKL----GFDFRPKCFKNDGSFENFNLT------------- 460
            ::.||               .|..:||    |:.|..|.   :|.|.:...:
plant   423 YKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKL---EGMFTDMKTSEDTMRGFYGSHPE 484

  Fly   461 --------------------------LPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEIT 499
                                      ||.|:....::||.:|.......:...|.|  :.:.:|.
plant   485 LSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTN--MGTADIK 547

  Fly   500 CHLNQ-SVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI----------KF 553
            ....: ..:.|.|||.||.||||||..:|.:.:|:..|..:....|:..|:.:          |.
plant   548 AIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKNVIKKE 612

  Fly   554 LVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDK--QVDAAIVRIMK 616
            .:..::.:.:...:|..||::..::.....:.:|..: .||.|...::..|:  |::||||||||
plant   613 PMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETE-PEKQETRQRVEEDRKPQIEAAIVRIMK 676

  Fly   617 GQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            .:|.|:::.:|:.|.::|:.|.....:.||||::.|:||::||||:. ..:||||
plant   677 SRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYL 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	168/767 (22%)
		CULLIN	362..500	CDD:214545	38/220 (17%)
		Cullin_Nedd8	606..661	CDD:287520	24/54 (44%)
CUL3	NP_174005.1	Cullin	29..630	CDD:395716	130/653 (20%)
CUL3	NP_174005.1	Cullin_Nedd8	662..721	CDD:402267	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820