DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL4

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_568658.1	Gene:	CUL4 / 834663	AraportID:	AT5G46210	Length:	792	Species:	Arabidopsis thaliana

Alignment Length:	766	Identity:	172/766 - (22%)
Similarity:	311/766 - (40%)	Gaps:	184/766 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQK---NGR 66
            |:||...:|:...:||:.         ....||:    ||..|.|:|  |.:.:...|.   ...
plant   110 KKISFDLESLYQAVDNLC---------LHKLDGK----LYDQIEKEC--EEHISAALQSLVGQNT 159

  Fly    67 SLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEH-WV---PYQRSCEKLNLACYHFNRN 127
            .|.:.||     |::. .|  ::..|....||.||..|:. :|   |..||..::.|..:..:.:
plant   160 DLTVFLS-----RVEK-CW--QDFCDQMLMIRSIALTLDRKYVIQNPNVRSLWEMGLQLFRKHLS 216

  Fly   128 W---VERERLKGDKETYPIYRLAMISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVL 189
            .   ||:..:||        .|:||. ||.:.|      |..|.:||.:         .:::..|
plant   217 LAPEVEQRTVKG--------LLSMIE-KERLAE------AVNRTLLSHL---------LKMFTAL 257

  Fly   190 QSIVELYANDKYQDVSLPSRIDKIFTEKVMDFY--------KSTTLHEFQKIVVSNDYKDFKHFL 246
            ...:|.:              :|.|.|...:||        :.:.:.|:.|.|....:::.:..:
plant   258 GIYMESF--------------EKPFLEGTSEFYAAEGMKYMQQSDVPEYLKHVEGRLHEENERCI 308

  Fly   247 RY--ACLAMPEIENGTQFKAILKRYLAARLQE---TRLSGK-------------------DYIQA 287
            .|  |....|.|.  |..:.:|:|::...|::   |.:.|:                   ...||
plant   309 LYIDAVTRKPLIT--TVERQLLERHILVVLEKGFTTLMDGRRTEDLQRMQTLFSRVNALESLRQA 371

  Fly   288 FLGLCRGPLQRALRDHTKLAEVV----------DAVCKEEINRK---GQIID------------- 326
            .....|...|:.:.|..|..::|          |.:.:|...:.   |..|.
plant   372 LSSYVRKTGQKIVMDEEKDKDMVQSLLDFKASLDIIWEESFYKNESFGNTIKDSFEHLINLRQNR 436

  Fly   327 PTRLLVTYANELMT--KRQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSD 389
            |..|:..:.:|.:.  .:..|||.:...|::::....|:..:..|...|.|.|..|.:...|.|.
plant   437 PAELIAKFLDEKLRAGNKGTSEEELESVLEKVLVLFRFIQGKDVFEAFYKKDLAKRLLLGKSASI 501

  Fly   390 GVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSK-----GIKLGF-----DFR 444
            ..|..|.|.|..:..:..|..:....:|::..:.:.:.|:....::     ||::..     .:.
plant   502 DAEKSMISKLKTECGSQFTNKLEGMFKDIELSKEINESFKQSSQARTKLPSGIEMSVHVLTTGYW 566

  Fly   445 PKCFKNDGSFENFNLTLPDEL---QQAWKEFRIF-YEARKLQSKAIIQLNNELSSGEITCHLNQS 505
            |       ::...::.||.||   |..:|||.:. |..|:|      ...|.|....:....::.
plant   567 P-------TYPPMDVKLPHELNVYQDIFKEFYLSKYSGRRL------MWQNSLGHCVLKADFSKG 618

  Fly   506 VYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQIKFLVYIEVNKVNYIEIN-- 568
            ...|.||..|..||||||...:.:.:::..:..:|.:.|:..|:.      :...||..::.|
plant   619 KKELAVSLFQAVVLMLFNDAMKLSFEDIKDSTSIEDKELRRTLQS------LACGKVRVLQKNPK 677

  Fly   569 -MDFTNRKRRLFCNE---PLPR------KMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQ 620
             .|..:.....|.:|   ||.|      :|:: :||.:....::.:|:  |:|||||||||.:|.
plant   678 GRDVEDGDEFEFNDEFAAPLYRIKVNAIQMKETVEENTSTTERVFQDRQYQIDAAIVRIMKTRKV 742

  Fly   621 LEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            |.::.||:.::::||..:||  :.:|||::.|::||||||: :...||.||
plant   743 LSHTLLITELFQQLKFPIKP--ADLKKRIESLIDREYLEREKSNPQIYNYL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	164/744 (22%)
		CULLIN	362..500	CDD:214545	31/151 (21%)
		Cullin_Nedd8	606..661	CDD:287520	27/54 (50%)
CUL4	NP_568658.1	Cullin	96..693	CDD:395716	132/664 (20%)
CUL4	NP_568658.1	Cullin_Nedd8	724..780	CDD:402267	27/57 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920