DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and CUL1

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001031575.1	Gene:	CUL1 / 825648	AraportID:	AT4G02570	Length:	738	Species:	Arabidopsis thaliana

Alignment Length:	775	Identity:	184/775 - (23%)
Similarity:	321/775 - (41%)	Gaps:	163/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLS 73
            :|..:.:..:..||:.:|:     .:||.::.|.||..||..|.     ..|.....:.||....
plant    13 DYMQTGITKLKRILEGLNE-----PAFDSEQYMMLYTTIYNMCT-----QKPPHDYSQQLYDKYR 67

  Fly    74 DCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            :...:.:.:.......:..|...:|.:.|   .|..::.....|:...|:.:|.::.|..|.
plant    68 EAFEEYINSTVLPALREKHDEFMLRELFK---RWSNHKVMVRWLSRFFYYLDRYFIARRSLP--- 126

  Fly   139 ETYPIYRLAMISWKELVFEP--SVTILAAIRLI-------------------------LSQMPRE 176
               |:..:.:..:::||:..  |....|.|.|:                         :.||.|
plant   127 ---PLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIGMGQMER- 187

  Fly   177 YNKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKI------FTEKVMDFYKSTT--------L 227
            |.:..|..:.|...|.....|:...|:.|.|..:.|.      ..|:|..:..|::        .
plant   188 YEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHSSSEPKLVEKVQ 252

  Fly   228 HEFQKIVVSNDYKDFKHFLRYACLAM----------------PEIENGTQFKA-ILKRYLAAR-- 273
            ||. .:|.::...:.:|   ..|.|:                .:|..|.:..| |.|:::.|.
plant   253 HEL-LVVFASQLLEKEH---SGCRALLRDDKVDDLSRMYRLYHKILRGLEPVANIFKQHVTAEGN 313

  Fly   274 -------------------LQETRLSGK-----DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVC 314
                               :||..|..|     |....::..|   .|.....|..|.|..:..|
plant   314 ALVQQAEDTATNQVANTASVQEQVLIRKVIELHDKYMVYVTEC---FQNHTLFHKALKEAFEIFC 375

  Fly   315 KEEINRKGQIIDPTRLLVTYANELMTK---RQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKA 376
            .:.:.....    ..||.|:.:.::.|   .:.|:|||.|.|:::||.:.::||:..|.:.|.|.
plant   376 NKTVAGSSS----AELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKK 436

  Fly   377 LRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSK-----G 436
            |..|.:.:.|.:|..|..:.:.|.::.....|..:...:.|:...|..:..|:|:|.|.     |
plant   437 LARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYLGSNPAANPG 501

  Fly   437 IKLGF-----DFRPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSG 496
            |.|..     .|.|       |:::|::.||.|:.:..:.|:.|||.:....|    |....|.|
plant   502 IDLTVTVLTTGFWP-------SYKSFDINLPSEMIKCVEVFKGFYETKTKHRK----LTWIYSLG 555

  Fly   497 EITCHLN----QSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFL 554
              |||:|    |....|.|||.|.|||:|||..::.:..|::..|.:..|.|...|..:   |:.
plant   556 --TCHINGKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDLVRLLHSLSCAKYK 618

  Fly   555 VYIE------VNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAI 611
            :.::      |::.:..|.|..||:|.||:  ..|||    .::|:.::...:.:|::  :||||
plant   619 ILLKEPNTKTVSQNDAFEFNSKFTDRMRRI--KIPLP----PVDERKKVVEDVDKDRRYAIDAAI 677

  Fly   612 VRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNYY-NIYRYL 670
            |||||.:|.|.:.:|:|...|:|....||.:..||||::.|:.|:|||||... |::|||
plant   678 VRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYL 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	179/757 (24%)
		CULLIN	362..500	CDD:214545	36/147 (24%)
		Cullin_Nedd8	606..661	CDD:287520	26/56 (46%)
CUL1	NP_001031575.1	Cullin	12..641	CDD:395716	142/671 (21%)
CUL1	NP_001031575.1	Cullin_Nedd8	668..729	CDD:402267	29/60 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820