Protein Alignment Cul6 and cul5

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001072836.1
• Gene: cul5 / 780297
• XenbaseID: XB-GENE-484069
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 811
• Identity: 176/811 - (21%)
• Similarity: 325/811 - (40%)
• Gaps: 201/811 - (24%)

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
 Frog    19 WDFMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGPAKIHQALKED 68

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--RLKGD 137
            ::..:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  ..|.:
 Frog    69 ILDFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSN 129

  Fly   138 KETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
            .|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|.:|
 Frog   130 VEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNLCSNP 191

  Fly   199 -DK---YQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIENG 259
             ||   |:|     ..:|.:.:....||::......|:..|.|       :::||...:.|.||
 Frog   192 EDKLQIYRD-----NFEKAYLDSTERFYRTQAPSYLQQNGVQN-------YMKYADAKLKEEEN- 243

  Fly   260 TQFKAILKRYLAAR--------LQETRLSG--KDYIQAFLGLCRG-------------------- 294
               :|:  |||..|        |.|..::.  ..:.:..|..|:|
 Frog   244 ---RAL--RYLETRRECNSVQALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV 303

  Fly   295 -----PLQRALRDHTKLAEVVDAVCKEE----------------INRKGQII------DP----- 327
                 |:.:.|.:|...|.:.|.|...|                .||..:::      ||
 Frog   304 PNGIEPMLKDLEEHIVSAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTA 368

  Fly   328 ------------------------------------TRLLVTYANELMTK----RQESEEAIIDE 352
                                                ..||..|.:.|:.|    ::.:.|.|..:
 Frog   369 RDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAK 433

  Fly   353 LKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNK--KMANFVTRCIYVQL 415
            ||.::..::::.::..|:..:...|..|.|.:.|....:|..|...|.:  ..|::|.: :....
 Frog   434 LKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNK-LARMF 497

  Fly   416 RDVDKLRTLKKEFQD-HLNSKGIKLGFDFRPKCFKNDG----SFENFNLTLPDELQQAWKEFRIF 475
            :|:.....|.:.|:: |.|:| :.|..|.......|.|    |.|...::||.||:....|...|
 Frog   498 QDIKVSEDLNQAFKEMHKNNK-LALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEF 561

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHER----FTEQELVTA 536
            |  :|..|...:..::.:|:|.||.......|.|||:|.|:|||..:|:..|    |...:|.|.
 Frog   562 Y--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE 624

  Fly   537 L-GVEL-ETLQE--ALKQIKFLVYIEVNKVNYIEINMDFT-------NRKRRLFCNEPLPR---- 586
            | ..|| .||..  |..::|..|......||..:   |||       |::..|..|..:.:
 Frog   625 LPDAELRRTLWSLVAFPKLKRQVLSYEPTVNSPK---DFTEGTLFSVNQEFSLIKNGKVQKRGKI 686

  Fly   587 -----------KMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKP 640
                       :||:.|.:..::|:|.|.::   ||::|||.:|::..::|.:.:.|.||:...|
 Frog   687 NLIGRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRKKITNAQLQTELVEILKNMFLP 748

  Fly   641 QVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            |...||:::::|:|.:|::|| :..|.:.|:
 Frog   749 QKKMIKEQIEWLIEHKYIKRDESDINTFIYM 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	171/795 (22%)
cul5	NP_001072836.1	Cullin	19..672	CDD:459983	147/699 (21%)
		Cullin_Nedd8	711..772	CDD:463146	21/63 (33%)