DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul4b

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001103612.1	Gene:	Cul4b / 72584	MGIID:	1919834	Length:	970	Species:	Mus musculus

Alignment Length:	756	Identity:	169/756 - (22%)
Similarity:	301/756 - (39%)	Gaps:	175/756 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLMHLYHLIYKQCAAERNW--------NNPAQKNGRSLYIVLSDCLMKRLK-NIAW 85
            ::||....|||......|....:.:.|.        |..:.|...:||..|.......:| .|..
Mouse   267 ENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQ 331

  Fly    86 VMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMIS 150
            ..|:.||.   :..:.|....|..:.|....:.......:|.:|.:..:...     |:.:.:..
Mouse   332 FREDSLDS---VLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPS-----IWDMGLEL 388

  Fly   151 WKELVFEPSVTILAAIRLILSQMPREYN---------KSL-----EYQVY------QVLQSIVEL 195
            ::..:..........|..||..:.||.|         :||     :.|:|      |.||....|
Mouse   389 FRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRL 453

  Fly   196 YAND---KYQDVSLPS---RIDKIFTE---KVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACL 251
            ||.:   ..|:..:|.   .::|...|   :::.:...||    ||.::::..|...
Mouse   454 YAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTT----QKSLIASVEKQLL-------- 506

  Fly   252 AMPEIENGTQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRAL---------------- 300
                   |....|||::.|.:.|.|.|:.....:.......||.:|..|
Mouse   507 -------GEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVI 564

  Fly   301 ---RDHTKLAEVVDAVCKEEINRKGQIID---------------------------PTRLLVTYA 335
               :|.|.:.|::|  .|::::   .|||                           |..|:..|.
Mouse   565 NPEKDKTMVQELLD--FKDKVD---HIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYV 624

  Fly   336 NELMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMY 396
            :..:  |..::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...|..|.
Mouse   625 DSKL--RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSML 687

  Fly   397 SLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKCFKNDG 452
            |.|..:.....|..:....:|::..:.:..:|:.::.::.:.         |...:.|
Mouse   688 SKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWP------- 745

  Fly   453 SFENFNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQSVYILE 510
            ::....:.||.|:.:..:.|:.||    ..||||.::.:   .|..|...|:..         |:
Mouse   746 TYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKE---------LQ 801

  Fly   511 VSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE------ 566
            ||..|..||::||..|.|:.:|:..|.|:|...|:..|:.:   |..|..:..|...||
Mouse   802 VSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFI 866

  Fly   567 INMDFTNRKRRLFCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELIS 628
            .|.||.::..|:..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.::.|:|
Mouse   867 CNDDFKHKLFRIKINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVS 928

  Fly   629 LVYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            .||.:||..|||  :.:|||::.|::|:|:|||    |.||
Mouse   929 EVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYN 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/756 (22%)
		CULLIN	362..500	CDD:214545	30/153 (20%)
		Cullin_Nedd8	606..661	CDD:287520	28/54 (52%)
Cul4b	NP_001103612.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q13620	112..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..211
		Cullin	275..870	CDD:279260	126/644 (20%)
		CULLIN	653..793	CDD:214545	28/146 (19%)
		Cullin_Nedd8	899..964	CDD:214883	31/66 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820