Protein Alignment Cul6 and Cul2

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_083678.2
• Gene: Cul2 / 71745
• MGIID: 1918995
• Length: 745
• Species: Mus musculus
• Alignment Length: 791
• Identity: 159/791 - (20%)
• Similarity: 310/791 - (39%)
• Gaps: 178/791 - (22%)

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVV----------NQIFDDYTSFDGQKLMHLYHLIYKQCAAER 55
            |:...|:.::.::...|:..|..||          |..|.|               ||..|.|
Mouse     1 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD---------------IYALCVA-- 48

  Fly    56 NWNNPAQKNGRSLYIVLSDCLMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNL 119
             :..|.   |..||......|...:::: ..|:|::      .:::..|..:|..|.:..:.::.
Mouse    49 -YPEPL---GERLYAETKIFLESHVRHLYKRVLESE------EQVLVMYHRYWEEYSKGADYMDC 103

  Fly   120 ACYHFNRNWVERERLKGDKETY------------PIYRLAMISWKELVFEPSVTILAAIRLILSQ 172
            ...:.|..::::.:|......|            .|..||:..|::|:.||...||  ||::|.:
Mouse   104 LYRYLNTQYIKKNKLTEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNIL--IRMLLRE 166

  Fly   173 MP-----------------------REYNKSLEYQVYQ------VLQSIVELY---ANDKYQDVS 205
            :.                       .:|.|....:.||      .|....|.|   |::..|:.:
Mouse   167 IKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESN 231

  Fly   206 LPSRIDKIFTEKVMDFYK---------------STTLHEFQKIVVSNDYKDFKHFLRYAC--LAM 253
            ...     :.|||:...|               :..:||.|:.:|:    |...||...|  :..
Mouse   232 CSQ-----YMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVA----DHLQFLHSECHSIIQ 287

  Fly   254 PEIENGTQFKAILKRYLAARL----QETRLSGKDY-IQAFLGLCRGPL-----QRALRDHTKLAE 308
            .|.:|......:|.|.:::.|    :|.:....|. ::|...|.:..:     :..|..|.|..:
Mouse   288 QERKNDMANMYVLLRAVSSGLPHMIEELQKHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQ 352

  Fly   309 VVDAVCKEE--------------INRK--GQIIDPTRLLVTYANELMTKRQE--SEEAIIDELKR 355
            :::.|...:              :|.:  ..:.....||..|.:.|:.|..:  :|..:.|:|..
Mouse   353 LINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTS 417

  Fly   356 IVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDK 420
            .:...:::.|:..|...|.:.|..|.|:..|.|...|..|.:.|.:......|..::....|:..
Mouse   418 FITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSV 482

  Fly   421 LRTLKKEFQDHLNSKG--IKLGFDFR---------PKCFKNDGSFENFNLTLPDELQQAWKEFRI 474
            ...|..:|.:.:.::.  |.||..|:         |.......:|     .:|.||:::.:.|.:
Mouse   483 SADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF-----AIPQELEKSVQMFEL 542

  Fly   475 FYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV 539
            || ::....:.:..| :.|.:||:..:.....|:..|:|.|||||:.||..|..:.:||..:..:
Mouse   543 FY-SQHFSGRKLTWL-HYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQM 605

  Fly   540 ELETLQEALKQIKFLVYIEVNKVNY------------IEINMDFTNRKRRLFCNEPLPRKMRKIE 592
            ..:.|.:.:|.:     ::|..:|:            ..:||.|::::.:......:.:...:..
Mouse   606 NEKELTKTIKSL-----LDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQEL 665

  Fly   593 EKSEIELKIRRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREY 657
            |::...:...|...:.||||||||.:|.|.::.||..|..:.:.|..|.:|.|||.::.|::::|
Mouse   666 EQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQY 730

  Fly   658 LER-----DNY 663
            :||     |.|
Mouse   731 IERSQASADEY 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	154/767 (20%)
Cul2	NP_083678.2	Cullin	14..644	CDD:459983	129/679 (19%)
		Cullin_Nedd8	675..735	CDD:463146	24/59 (41%)