DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul5

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	XP_006243152.1	Gene:	Cul5 / 64624	RGDID:	621742	Length:	828	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	176/767 - (22%)
Similarity:	325/767 - (42%)	Gaps:	140/767 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDC 75
            :|.|.|:   :|:::.|     .|...|:...|:..::..|.    |::   |....::..|.:.
  Rat    94 WDFMRPI---VLKLLRQ-----ESVTKQQWFDLFSDVHAVCL----WDD---KGSSKIHQALKED 143

  Fly    76 LMKRLKNI-AWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERE--RLKGD 137
            :::.:|.. |.|:.:| ||.   .|:..|:..|..:...|:.|...........:.::  ..|.:
  Rat   144 ILEFIKQAQARVLSHQ-DDT---ALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSN 204

  Fly   138 KETYPIYRLAMISWKELVFEPSVTIL--AAIRLI-LSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
            .|...:.:|.:.:|.|.:|......|  :|::|: ..::...::..|   |..|.:|.|.|.:|
  Rat   205 MEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQL---VIGVRESYVNLCSNP 266

  Fly   199 -DK---YQD---------------VSLPSRIDKIFTEKVMDF------------YKSTTLHEFQK 232
             ||   |:|               ...||.:.:...:..|.:            :|.|.|.|.|.
  Rat   267 EDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYLMECCVNALVTSFKETILAECQG 331

  Fly   233 IVVSNDYKDFKHFLRYACLAMPEIENGTQ--FKAILKRYLAARL-------QETRLSGKDYIQAF 288
            ::..|:.:  |..|.::  .|.::..|.:  .|.:.:..::|.|       :......:.|::..
  Rat   332 MIKRNETE--KLHLMFS--LMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQL 392

  Fly   289 LGLCR------------GPLQRALRDHTKLAEVVDA-VCKEEINRK----GQIIDP----TRLLV 332
            |.|..            .|.....||....|.|.|| :.|.|:..|    |....|    ..||.
  Rat   393 LTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLA 457

  Fly   333 TYANELMTK----RQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVES 393
            .|.:.|:.|    ::.:.|.|..:||.::..::::.::..|:..:...|..|.|.:.|....:|.
  Rat   458 NYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEE 522

  Fly   394 IMYSLLNK--KMANFVTRCIYVQLRDVDKLRTLKKEFQD-HLNSKGIKLGFDFRPKCFKNDG--- 452
            .|...|.:  ..|::|.: :....:|:.....|.:.|:: |.|:| :.|..|.......|.|
  Rat   523 NMVEWLREVGMPADYVNK-LARMFQDIKVSEDLNQAFKEMHKNNK-LALPADSVNIKILNAGAWS 585

  Fly   453 -SFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQM 516
             |.|...::||.||:....|...||  :|..|...:..::.:|:|.||.......|.|||:|.|:
  Rat   586 RSSEKVFVSLPTELEDLIPEVEEFY--KKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL 648

  Fly   517 AVLMLFNRHER----FTEQELVTAL-GVEL-ETLQE--ALKQIKFLVYIEVNKVN---------Y 564
            |||..:|:..|    |...:|.|.| ..|| .||..  |..::|..|.:...:||         .
  Rat   649 AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTL 713

  Fly   565 IEINMDFT---NRK--RRLFCN-----EPLPRKMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQK 619
            ..:|.||:   |.|  :|...|     :....:||:.|.:..::|:|.|.::   ||::|||.:|
  Rat   714 FSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQE---AIIQIMKMRK 775

  Fly   620 QLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNY-YNIYRYL 670
            ::..::|.:.:.|.||:...||...||:::::|:|.:|:.||.. .|.:.|:
  Rat   776 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYM 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	171/751 (23%)
		CULLIN	362..500	CDD:214545	34/144 (24%)
		Cullin_Nedd8	606..661	CDD:287520	17/54 (31%)
Cul5	XP_006243152.1	Cullin	95..719	CDD:279260	143/653 (22%)
		CULLIN	491..634	CDD:214545	35/146 (24%)
		Cullin_Nedd8	761..820	CDD:287520	20/61 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820