DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul4b

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001116316.1	Gene:	cul4b / 560313	ZFINID:	ZDB-GENE-041008-208	Length:	864	Species:	Danio rerio

Alignment Length:	761	Identity:	169/761 - (22%)
Similarity:	309/761 - (40%)	Gaps:	185/761 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DDYTSFDGQKLM-----------------HLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLM 77
            ::||:...|||.                 .||..:...|:     :..:.|..:.|.:|..|.:.
Zfish   161 ENYTNETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCS-----HKISAKLYKQLRVVCEDHIK 220

  Fly    78 KRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYP 142
            .::...   .|:.||.   :..:.|..:.|..:.|....:.......:|.:|.:..:      .|
Zfish   221 AQIDQF---REDALDS---VLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQNSM------LP 273

  Fly   143 --------IYRLAMISWKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSIVELYAN- 198
                    ::|..:||  :|..: |.||...:.||      |..:|.|.....:|:|::.:.::
Zfish   274 SIWDMGLELFRFYIIS--DLKVQ-SKTIDGILLLI------ERERSGEAVDRSLLRSLLSMLSDL 329

  Fly   199 DKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFL-----RYACLAMPEIEN 258
            ..|||     ..::.|.|:....|.:    |.|:::...:..::.|.:     ..|...:..::.
Zfish   330 QIYQD-----SFEQRFLEETNRLYAA----EGQRLMQEREVPEYLHHVNKRLEEEADRVITYLDQ 385

  Fly   259 GTQ---------------FKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQRAL-------- 300
            .||               ..|||::.|...|.|.|:.....:.......||.:|..|
Zfish   386 STQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIK 450

  Fly   301 -----------RDHTKLAEVVD---------AVC--KEE-------------INRKGQIIDPTRL 330
                       :|.|.:.|::|         .||  |.|             ||::..  .|..|
Zfish   451 AFGSTIVINPEKDKTMVQELLDFKDKVDHIIDVCFMKNEKFVNGMKEAFETFINKRPN--KPAEL 513

  Fly   331 LVTYANELMTKRQESEEAIIDELKRIVKCV----EFLSDEYKFIDMYLKALRIRQINETSTSDGV 391
            :..|.:..:  |..::||..:||::::..:    .|:..:..|...|.|.|..|.:...|.|...
Zfish   514 IAKYVDSKL--RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDA 576

  Fly   392 ESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIK---------LGFDFRPKC 447
            |..|.|.|..:.....|..:....:|::..:.:..:|:.|:..:.|.         |...:.|
Zfish   577 EKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWP-- 639

  Fly   448 FKNDGSFENFNLTLPDELQQAWKEFRIFY----EARKLQSKAII---QLNNELSSGEITCHLNQS 505
                 ::....:.||.|:.:..:.|:.||    ..||||.::.:   .|..|...|:..
Zfish   640 -----TYVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKE------ 693

  Fly   506 VYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQI---KFLVYIEVNKVNYIE- 566
               |:||..|..||::||..|.|:.:::..|.|:|...|:..|:.:   |..|..::.|...:|
Zfish   694 ---LQVSLFQTLVLLMFNEGEEFSLEDIKLATGIEDSELRRTLQSLACGKARVLTKIPKSKDVED 755

  Fly   567 -----INMDFTNRKRRLFCNEPLPRKMRK-IEEKSEIELKIRRDK--QVDAAIVRIMKGQKQLEY 623
                 .|.||.::..|:..|:   .:|:: :||::....::.:|:  |:|||||||||.:|.|.:
Zfish   756 GDKFSCNDDFKHKLFRIKINQ---IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSH 817

  Fly   624 SELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD----NYYN 665
            :.|:|.||.:||..|||  :.:|||::.|::|:|:|||    |.||
Zfish   818 NLLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYN 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/761 (22%)
		CULLIN	362..500	CDD:214545	32/153 (21%)
		Cullin_Nedd8	606..661	CDD:287520	28/54 (52%)
cul4b	NP_001116316.1	Cullin	169..764	CDD:279260	126/649 (19%)
		CULLIN	547..687	CDD:214545	30/146 (21%)
		Cullin_Nedd8	793..858	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920