Protein Alignment Cul6 and cul3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001015975.2
• Gene: cul3 / 548729
• XenbaseID: XB-GENE-974982
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 794
• Identity: 170/794 - (21%)
• Similarity: 301/794 - (37%)
• Gaps: 188/794 - (23%)

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:|:..|:.|.:|.:.:..:...||:     .||...|...         ..|:|..||..|.:
 Frog    29 YVNSIWDLLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLYTGLRE 79

  Fly    75 CLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            .:.:.|.| :...:.|.|::|    .:....:.|..:|.:...:.....:.:|.:|::..::.
 Frog    80 VVTEHLINKVREDVLNSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVEN-- 138

  Fly   139 ETYPIYRLAMISWKELVF---------------------EPSVTILAAIR------LILS----- 171
                :|.|.:|.:::.|.                     :..|....|||      :||.
 Frog   139 ----VYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRS 199

  Fly   172 -----------QMPREY-----NKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD 220
                       :|..|:     .|.|......|....||...|::.:.|.  ..:||...|.::.
 Frog   200 VYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCLDKSTEEPIVK 262

  Fly   221 FYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENG----TQFKAILKRYLAAR 273
            ..:...:.:..|.:|..:.....|.|:      .||:  ....:.||    .:..::..|.....
 Frog   263 VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSLYLREQGKA 327

  Fly   274 LQETRLSGK---DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEI----------NRKGQII 325
            |......||   ||||..|.| :....|.|::...    .|.:.|:.|          |.:.
 Frog   328 LVSEEGEGKNPVDYIQGLLDL-KSRFDRFLQESFS----NDRLFKQTIAGDFEYFLNLNSRS--- 384

  Fly   326 DPTRLLVTYANELMTK-----RQESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINET 385
              ...|..:.::.:.|     .::..|:|:|:...:.:   |:.::..|...|.:.|..|.:...
 Frog   385 --PEYLSLFIDDKLKKGVKGLTEQEVESILDKAMVLFR---FMQEKDVFERYYKQHLARRLLTNK 444

  Fly   386 STSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKL-GFDF------ 443
            |.||..|..|.|.|..:.....|..:....||:....|...||:.||.:.|:.| |.|.
 Frog   445 SVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQTTGVSLGGVDLTVRVLT 509

  Fly   444 ---------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEIT 499
                     .|||            .:|...:.|::.||.||.|:  .|...:.|.:.:.|.::.
 Frog   510 TGYWPTQSATPKC------------NIPPAPRHAFEIFRRFYLAK--HSGRQLTLQHHMGSADLN 560

  Fly   500 CHL----------------------NQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELE 542
            ...                      |...:||:|||.||.:|||||..|::|.:|:.....:...
 Frog   561 ATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPER 625

  Fly   543 TLQEALKQI-----------KFLVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSE 596
            .|..||:.:           |.....|:...:...:|..||::..|:.......::.....|:.|
 Frog   626 ELVRALQSLACGKPTQRVLTKEPKSKEIESGHMFTVNDQFTSKLHRVKIQTVAAKQGESDPERKE 690

  Fly   597 IELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLE 659
            ...|:..|:  :::||||||||.:|:::::.|::.|.::||.|..|....||||::.|:|||||.
 Frog   691 TRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLA 755

  Fly   660 R---DNYYNIYRYL 670
            |   |.  .:|.|:
 Frog   756 RTPEDR--KVYTYV 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	164/777 (21%)
cul3	NP_001015975.2	Cullin	34..665	CDD:459983	132/683 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	698..760	CDD:463146	27/61 (44%)