Protein Alignment Cul6 and AT1G43140

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_175007.2
• Gene: AT1G43140 / 3767291
• AraportID: AT1G43140
• Length: 721
• Species: Arabidopsis thaliana
• Alignment Length: 758
• Identity: 171/758 - (22%)
• Similarity: 309/758 - (40%)
• Gaps: 180/758 - (23%)

  Fly    25 VNQIFDDYTS--FDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSDCLMKRLKNIA--W 85
            :.:|.:|.:.  ||..:.::||.:||..|..:     |.....:.||        .:.:.:.  :
plant    31 LQRILEDLSEPPFDPGQYINLYTIIYDMCLQQ-----PPNDYSQELY--------NKYRGVVDHY 82

  Fly    86 VMENQLDDNKPIR---LIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLA 147
            ..|..|...:...   ::.:.::.|..::.....|:..|::.:|.:|.|..|.      .:..:.
plant    83 NKETVLPSMRERHGEYMLRELVKRWANHKILVRWLSRFCFYLDRFYVARRGLP------TLNDVG 141

  Fly   148 MISWKELVFEPSVTILAAIRLILSQMPRE--------------------------YNKSLEYQVY 186
            ..|:.:||::...:....:.|.|....||                          |.:..|..:.
plant   142 FTSFHDLVYQEIQSEAKDVLLALIHKEREGEQIDRTLVKNVIDVYCGNGVGQMVIYEEDFESFLL 206

  Fly   187 QVLQSIVELYANDKYQDVSLPS---------RIDKIFTEKVMDFYKSTT----LHEFQK---IVV 235
            |...|.....|:...|:.|.|.         :::|   |:|.::..|||    :.:.|.   :||
plant   207 QDTASYYSRKASRWSQEDSCPDYMLKAEECLKLEK---ERVTNYLHSTTEPKLVEKVQNELLVVV 268

  Fly   236 SNDYKDFKHFLRYACLAMPE----------------IENGTQ-----FK--------AILKRYL- 270
            :....:.:|   ..|||:..                |..|.:     ||        |::|:..
plant   269 AKQLIENEH---SGCLALLRDDKMGDLSRMYRLYRLIPQGLEPIADLFKQHVTAEGNALIKQAAD 330

  Fly   271 AARLQETRLSG---------KDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIID 326
            ||..|:...|.         .|....::..|   .|:....|..|.|..:..|.:.:.....
plant   331 AATNQDASASQVLVRKEIELHDKYMVYVDEC---FQKHSLFHKLLKEAFEVFCNKTVAGASS--- 389

  Fly   327 PTRLLVTYANELMTKRQESEEAIIDE-----LKRIVKCVEFLSDEYKFIDMYLKALRIRQINETS 386
             ..:|.||.:.::..|..||: :.||     |:::|..:.::||:..|.:.|.|....|.:.:.|
plant   390 -AEILATYCDNILKTRGGSEK-LSDEATEITLEKVVNLLVYISDKDLFAEFYRKKQARRLLFDRS 452

  Fly   387 TSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSK-GIKLGFDFRPKCFKN 450
            .                       |..::.|:...|.|:..|.|:|::. ..|||.||.......
plant   453 G-----------------------IMKEVTDITLARELQTNFVDYLSANMTTKLGIDFTVTVLTT 494

  Fly   451 D--GSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHL----NQSVYIL 509
            .  .|::..:|.||.|:....:.|::|| ..|..|:   :|:...|.|  |||:    .:....|
plant   495 GFWPSYKTTDLNLPTEMVNCVEAFKVFY-GTKTNSR---RLSWIYSLG--TCHILGKFEKKTMEL 553

  Fly   510 EVSTLQMAVLMLFNRHERFTEQELVTALGV---ELETLQEALKQIKFLVYIE------VNKVNYI 565
            .|||.|.|||:|||..||.:..|:...|.:   :|..|..:|..:|:.:.|:      ::|.:..
plant   554 VVSTYQAAVLLLFNNAERLSYTEISEQLNLSHEDLVRLLHSLSCLKYKILIKEPMSRTISKTDTF 618

  Fly   566 EINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELIS 628
            |.|..||::.|::  ..|||    .::|:.::...:.:|::  :|||:|||||.:|.|.:.:|:|
plant   619 EFNSKFTDKMRKI--RVPLP----PMDERKKVVEDVDKDRRYAIDAALVRIMKSRKVLAHQQLVS 677

  Fly   629 LVYEELKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            ...|.|....||.:..||||::.|:.|:||||| ...|.::|:
plant   678 ECVEHLSKMFKPDIKMIKKRIEDLINRDYLERDTENANTFKYV 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	170/756 (22%)
AT1G43140	NP_175007.2	Cullin	21..624	CDD:459983	134/654 (20%)
		Cullin_Nedd8	651..713	CDD:463146	28/61 (46%)