DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul1

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	807	Identity:	218/807 - (27%)
Similarity:	354/807 - (43%)	Gaps:	171/807 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNR------VKRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAA------ 53
            |||      .:::.|..|....|::.|:||    |:...|....:.|..|..:|..|.:
  Fly     1 MNRSGNSQTTQKLVNLDDIWSELVEGIMQV----FEHEKSLTRSQYMRFYTHVYDYCTSVSAAPS 61

  Fly    54 --ERNWNNPAQKNGRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIR----LIAKYLEHWVPYQR 112
              .......||..|:.||..|...|...|..:       |...|.|.    |:::|.:.|..||.
  Fly    62 GRSSGKTGGAQLVGKKLYDRLEQFLKSYLSEL-------LTKFKAISGEEVLLSRYTKQWKSYQF 119

  Fly   113 SCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKELVF----EPSVTILAAIRLILSQM 173
            |...|:..|.:.|||||:||..:|.|..|.|||||:::||..:|    || ||     :.:|..:
  Fly   120 SSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEP-VT-----KAVLKSI 178

  Fly   174 PRE-----YNKSLEYQVYQVLQSIVELYANDKYQDV----------SLPSRI---DKIFTEKVMD 220
            ..|     .|:||   |..|::..|||..|::..|.          :..::.   ...|.||..|
  Fly   179 EEERQGKLINRSL---VRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESD 240

  Fly   221 FYKSTT-------------------------------LH-------------------------E 229
            .:.||.                               ||                         |
  Fly   241 AFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTE 305

  Fly   230 FQKIVVSNDYKDFKHFLRYACLAMPEIENGTQFKAILKRYL-------AARLQETRLSG--KDYI 285
            ||.::.::...|.|..  |:.:|:.. :|.|..|:||:.::       .|:...|..:.  |.|:
  Fly   306 FQNLLNADRNDDLKRM--YSLVALSS-KNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYV 367

  Fly   286 QAFLGLCR---GPLQRALRDHTKLAEVVDAVCKEEINRKGQII-----DPTRLLVTYANELMTKR 342
            |..|.:.:   ..:..|..:.......:|..|.:.||.....|     ....||..|.:.|:.|.
  Fly   368 QTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKS 432

  Fly   343 QESEE--AIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMAN 405
            .::.|  .:.|.|.:::...:::.|:..|...|.|.|..|.:|.||.||..|::|.|.|.:....
  Fly   433 SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGY 497

  Fly   406 FVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKNDGSFE---NFNLTLPDELQQ 467
            ..|..:....:|:...:.|...|:.:|..|.:.:..||..:.. :.||:.   :.|..||.||::
  Fly   498 EYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVL-SSGSWPFQLSNNFLLPSELER 561

  Fly   468 AWKEFRIFYEARKLQSKAIIQLN--NELSSGEITCHLNQ---SVYILEVSTLQMAVLMLFNRHER 527
            :.::|..||.||....|    ||  .::..||:..::|:   |.|.|:.||.||:||:.||....
  Fly   562 SVRQFNEFYAARHSGRK----LNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLS 622

  Fly   528 FTEQELVTALGVELETLQEALKQI-KFLVYIEV-------NKV---NYIEINMDFTNRKRRLFCN 581
            ||.|:|..    ..:|.||.|.|: :.|:..:|       |.:   :.:|:.:|:.|:|||:..|
  Fly   623 FTVQQLQD----NTQTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININ 683

  Fly   582 EPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSF 644
            :||..:: |:|::: :...|..|::  :.||||||||.:|:|.::.|||.|..:|..|.||:|..
  Fly   684 QPLKTEL-KVEQET-VHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPV 746

  Fly   645 IKKRLDYLVEREYLER-DNYYNIYRYL 670
            |||.:|.|:|:||||| :.:.:.|.||
  Fly   747 IKKCIDILIEKEYLERMEGHKDTYSYL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	207/775 (27%)
		CULLIN	362..500	CDD:214545	40/142 (28%)
		Cullin_Nedd8	606..661	CDD:287520	30/57 (53%)
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	167/679 (25%)
		CULLIN	454..593	CDD:214545	40/143 (28%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850