Protein Alignment Cul6 and Cul3

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Alignment Length: 827
• Identity: 182/827 - (22%)
• Similarity: 307/827 - (37%)
• Gaps: 247/827 - (29%)

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:::...:.|.:|.:.:..:...||:     .||...|         |....|:|..||..|.:
  Fly   188 YVETIWASLKNAIQEIQKKNNSGLSFE-----QLYRNAY---------NMVLHKHGNRLYYGLRE 238

  Fly    75 CLMKRL--KNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGD 137
            .:.:.|  |..|.|:| .|..|    .:.|..:.|..:|.|...:.....:.:|.:|::
  Fly   239 VVSEHLEHKVRADVLE-ALHSN----FLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQ------ 292

  Fly   138 KETYPIYRLAMISWKELVFEPSVTILAAIR--LILSQMPREYNKSLEY-QVYQVLQSIVELYAND 199
            :|...:|.|.:|.:::.|...| .|..|:|  |:...|...:.:::.: .:......::.|..|.
  Fly   293 REVDNVYNLGLILFRDQVVRYS-EIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINS 356

  Fly   200 K--YQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSND---------------------YKD 241
            :  |::     ..:|.|..:...|||    .|.|..:..|:                     |.|
  Fly   357 RTVYEE-----DFEKPFLAQSAAFYK----FESQNFLAENNAGVYIKKVEARITEESSRAALYLD 412

  Fly   242 ---------------FKHFLRYACLAMPEIEN--------GTQFKAILKRY-LAARLQETRLSG- 281
                           .|..:|    .:.|:||        .::.:.:...| |.:||:|..|..
  Fly   413 KDTEPRIVRVVEEELIKKHMR----PIVEMENSGVVYMIKNSKTEDLACTYKLFSRLKEEGLKVI 473

  Fly   282 KDYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTR------------LLVTY 334
            .|.:.|:           ||:..::      :.|||.|.....|...:            |:.::
  Fly   474 ADTMSAY-----------LREQGRM------LVKEEENGNTNPITFVQNLLDLKDRFDQFLVHSF 521

  Fly   335 ANE----------------LMTKRQE-----------------SEEAIIDELKRIVKCVEFLSDE 366
            ||:                |..|..|                 ||:.|...|.:.:....||.::
  Fly   522 ANDRIFKNVISSDFEHFLNLNNKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEK 586

  Fly   367 YKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDH 431
            ..|...|...|..|.:...|.||..|..|.|.|..:.....|..:....:|:....|:..||::.
  Fly   587 DVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNF 651

  Fly   432 LNSKGIKLG--------------------------------FDFRPKCFKNDGSFENF------- 457
            :|:..:.||                                ||.          |:||
  Fly   652 VNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDI----------FKNFYLNKHSG 706

  Fly   458 -NLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSGEITCHLNQSV--YILEVSTLQMAVL 519
             .|||..::..|:.. .:||..:.::|:......:..|||   |.:..:.  :||:|||.||.||
  Fly   707 RQLTLQPQMGTAYIN-AVFYGRKAVESEKDKDAPSSSSSG---CGVPTTTRKHILQVSTYQMCVL 767

  Fly   520 MLFNRHERFT-----------EQELVTALGVELETLQEALKQIKFLVYIEVNKVNYIEINMDFTN 573
            :|||..:..|           |:|||.|    |::|.......:.||.....|...||...:|
  Fly   768 LLFNNRDVLTYDDIHQETDIPERELVRA----LQSLSMGKPAQRLLVRNSKTKTKDIEPTDEF-- 826

  Fly   574 RKRRLFCNEPLPRKMRKIE------------EKSEIELKIRRDK--QVDAAIVRIMKGQKQLEYS 624
                 :.|:....|..:::            |:.|...|:..|:  :::||||||||.:|:|.::
  Fly   827 -----YVNDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHN 886

  Fly   625 ELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERD-NYYNIYRYL 670
            .|:|.|..:||.|..|...|||||::.|:|||||:|. ....:|.||
  Fly   887 LLVSDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYL 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	177/810 (22%)
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	144/719 (20%)
		Cullin_Nedd8	864..926	CDD:463146	30/61 (49%)