DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul1a

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_955953.2	Gene:	cul1a / 323883	ZFINID:	ZDB-GENE-030131-2603	Length:	777	Species:	Danio rerio

Alignment Length:	784	Identity:	205/784 - (26%)
Similarity:	352/784 - (44%)	Gaps:	162/784 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VNQIFDD--------YT--SFDGQKLMHLYHLIYKQCAAERNWN----------NPAQKN----- 64
            ::||:||        ||  |....:.|.||..:|..|.:....|          .|::|.
Zfish    17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQVRGGGPAPSKPSKKTPTPGG 81

  Fly    65 ----GRSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFN 125
                |..||..|.:.|...|.|:....|:.:|::    ::..|.:.|..|:.|.:.||..|.:.|
Zfish    82 AQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDES----VLKFYTQQWEDYRFSSKVLNGICAYLN 142

  Fly   126 RNWVERERLKGDKETYPIYRLAMISWKELVFEP---SVT--ILAAI-----------RLI----- 169
            |:||.||..:|.|..|.||.||:::|:|.:|.|   .||  :|..|           |||
Zfish   143 RHWVRRECDEGRKGIYEIYSLALVTWRECLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQ 207

  Fly   170 ---------------------------------------------LSQMP-REYNKSLEYQVYQV 188
                                                         |.|.| .||.|..|.::.:.
Zfish   208 SYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEE 272

  Fly   189 LQSIVELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAM 253
             |..|::|.::..|| .|..:.:::..||.::.:.:    |||.::.::..:|......    .:
Zfish   273 -QRRVQVYLHESTQD-ELARKCEQVLIEKHLEIFHT----EFQNLLDADKNEDLGRMYN----LV 327

  Fly   254 PEIENGT-QFKAILKRY-----LAA--RLQETRLSG-KDYIQAFLGLCR---GPLQRALRDHTKL 306
            ..|.:|. :.|.:|:.:     |||  :..|:.|:. |.|:|..|.:.:   ..:..|..:....
Zfish   328 SRITDGLGELKKLLETHIYNQGLAAIEKCGESALNDPKMYVQTILDVHKKYNALVMSAFNNDAGF 392

  Fly   307 AEVVDAVCKEEINRKG--QIIDPT----RLLVTYANELMTKRQES-EEA-IIDELKRIVKCVEFL 363
            ...:|..|...||...  :::..:    .||..|.:.|:.|..:: ||| :.|.|.:::...:::
Zfish   393 VAALDKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYI 457

  Fly   364 SDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEF 428
            .|:..|...|.|.|..|.:::.|.||..|:.|.|.|.:......|..:....:|:...:.|.::|
Zfish   458 EDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQF 522

  Fly   429 QDHL-NSKGIKLGFDFRPKCFKNDGSF---ENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQL 489
            :.|| ||:.:.|.|..:   ..:.||:   ::....||.||:::::.|..||.:|....|  :..
Zfish   523 KKHLTNSEPLDLDFSIQ---VLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRK--LTW 582

  Fly   490 NNELSSGEITCHLNQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELETLQEALK---QI 551
            ...||.||:..:..::.|.|:.||.|||:|:.:|..:.:|.|:|..:..::::.|.:.|:   :.
Zfish   583 LYHLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDVYTVQQLTDSTQIKIDILVQVLQILLKS 647

  Fly   552 KFLVYIEVN-KVNYIEINMD--------FTNRKRRLFCNEPLPRKMRKIEEKSEIEL---KIRRD 604
            |.||..:.| .|:.:|...|        :.|:|.|:..|.|:     |.|:|.|.|.   .|..|
Zfish   648 KLLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNINVPM-----KTEQKQEQETTHKNIEED 707

  Fly   605 KQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNI 666
            ::  :.||||||||.:|.|::.:|::.|..:|..|.||:|..|||.:|.|:|:||||| |...:.
Zfish   708 RKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDT 772

  Fly   667 YRYL 670
            |.||
Zfish   773 YSYL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	203/782 (26%)
		CULLIN	362..500	CDD:214545	38/141 (27%)
		Cullin_Nedd8	606..661	CDD:287520	28/57 (49%)
cul1a	NP_955953.2	Cullin	22..661	CDD:307166	157/657 (24%)
cul1a	NP_955953.2	Cullin_Nedd8	704..771	CDD:214883	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880