DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and Cul3

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_057925.1	Gene:	Cul3 / 26554	MGIID:	1347360	Length:	768	Species:	Mus musculus

Alignment Length:	797	Identity:	175/797 - (21%)
Similarity:	298/797 - (37%)	Gaps:	194/797 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNGRSLYIVLSD 74
            |.:|:..|:.|.:|.:.:..:...||:     .||...|...         ..|:|..||..|.:
Mouse    29 YVNSIWDLLKNAIQEIQRKNNSGLSFE-----ELYRNAYTMV---------LHKHGEKLYTGLRE 79

  Fly    75 CLMKRLKN-IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDK 138
            .:.:.|.| :...:.|.|::|    .:....:.|..:|.:...:.....:.:|.:|::..::.
Mouse    80 VVTEHLINKVREDVLNSLNNN----FLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVEN-- 138

  Fly   139 ETYPIYRLAMISWKELVF---------------------EPSVTILAAIR------LILS----- 171
                :|.|.:|.:::.|.                     :..|....|||      :||.
Mouse   139 ----VYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRS 199

  Fly   172 -----------QMPREY-----NKSLEYQVYQVLQSIVELYANDKYQDVSLPSRIDKIFTEKVMD 220
                       :|..|:     .|.|......|....||...|::.:.|.  ..:||...|.::.
Mouse   200 VYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVM--HCLDKSTEEPIVK 262

  Fly   221 FYKSTTLHEFQKIVVSNDYKDFKHFLR------YACL--AMPEIENGTQ-----FKAILKRYLAA 272
            ..:...:.:..|.:|..:.....|.|:      .||:  ....:.||.:     ....|:....|
Mouse   263 VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKA 327

  Fly   273 RLQETRLSGK---DYIQAFLGLCRGPLQRALRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLVTY 334
            .:.|.. .||   ||||..|.| :....|.|::...    .|.:.|:.|  .|..        .|
Mouse   328 LVSEEG-EGKNPVDYIQGLLDL-KSRFDRFLQESFN----NDRLFKQTI--AGDF--------EY 376

  Fly   335 ANELMTKRQESEEAIIDE-LKRIVK----------------CVEFLSDEYKFIDMYLKALRIRQI 382
            ...|.::..|.....||: ||:.||                ...|:.::..|...|.:.|..|.:
Mouse   377 FLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLL 441

  Fly   383 NETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKL-GFDF--- 443
            ...|.||..|..|.|.|..:.....|..:....||:....|...||:.||.:.|:.| |.|.
Mouse   442 TNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVR 506

  Fly   444 ------------RPKCFKNDGSFENFNLTLPDELQQAWKEFRIFYEARKLQSKAIIQLNNELSSG 496
                        .|||            .:|...:.|::.||.||.|:  .|...:.|.:.:.|.
Mouse   507 VLTTGYWPTQSATPKC------------NIPPAPRHAFEIFRRFYLAK--HSGRQLTLQHHMGSA 557

  Fly   497 EITCHL----------------------NQSVYILEVSTLQMAVLMLFNRHERFTEQELVTALGV 539
            ::....                      |...:||:|||.||.:|||||..|::|.:|:.....:
Mouse   558 DLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDI 622

  Fly   540 ELETLQEALKQI-----------KFLVYIEVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEE 593
            ....|..||:.:           |.....|:...:...:|..||::..|:.......::.....|
Mouse   623 PERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPE 687

  Fly   594 KSEIELKIRRDK--QVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVERE 656
            :.|...|:..|:  :::||||||||.:|:::::.|::.|.::||.|..|....||||::.|:|||
Mouse   688 RKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIERE 752

  Fly   657 YLER---DNYYNIYRYL 670
            ||.|   |.  .:|.|:
Mouse   753 YLARTPEDR--KVYTYV 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	169/780 (22%)
		CULLIN	362..500	CDD:214545	37/153 (24%)
		Cullin_Nedd8	606..661	CDD:287520	26/57 (46%)
Cul3	NP_057925.1	Interaction with KLHL18. /evidence=ECO:0000250\|UniProtKB:Q13618	2..41		4/11 (36%)
		Cullin	35..664	CDD:279260	137/684 (20%)
		CULLIN	421..563	CDD:214545	37/155 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		3/20 (15%)
		Cullin_Nedd8	700..760	CDD:287520	26/59 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810