DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and pcu4

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_594195.1	Gene:	pcu4 / 2543116	PomBaseID:	SPAC3A11.08	Length:	734	Species:	Schizosaccharomyces pombe

Alignment Length:	757	Identity:	164/757 - (21%)
Similarity:	303/757 - (40%)	Gaps:	170/757 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRVKRISNYFDSMLPLIDNILQVVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNPAQKNG 65
            :.|..:.|..|:.:...:.:.:|::....:.:...:|.:.......:...|     ||...::
pombe    60 LTRADQASRCFNILQHHMSSGIQLLKDSAESFIQLEGTETDTNACTVVVGC-----WNKWLER-- 117

  Fly    66 RSLYIVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVE 130
                       ::.::||.:.|:.            .:|.|...|. :.|:|:|:.:
pombe   118 -----------VEIVQNIFYYMDK------------TFLSHHPDYP-TIEELSLSLF-------- 150

  Fly   131 RERLKGDKE-TYPIYRLAMISWKELVFEPSV--TILAAIRLILSQMPREYNKSLEYQVYQVLQSI 192
            ||:|...|. ..|.....:.|::.|....|.  ..|....|:|.:  .|...|:...:|.|:.|
pombe   151 REKLMAVKNIQIPFLNSLLQSFENLHSSKSTDHAYLQDAMLMLHR--TEMYSSVFVPMYLVMLS- 212

  Fly   193 VELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLHE---FQKIVVSNDYKDFKHFLRYACLAMP 254
                   ::.|.....:|.::..|:.:::..|:...|   .:|..:..|.|..:..:: .||...
pombe   213 -------RFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQ-RCLITS 269

  Fly   255 EIENGT----QFKAILKR------YLAARLQ---ETRL--------------------SGKDYIQ 286
            .::..|    ||  |.||      .|.|.||   ||..                    |..|.:
pombe   270 HLDTLTKGISQF--IEKRDAHSCKLLYALLQFNHETEYLIQPWSDCLVDVGFKLVNDESKDDTL- 331

  Fly   287 AFLGLCRGPLQRALRDHTKLAEVVD-AVCKEE-------------IN-RKG-QIIDPTRLLVTYA 335
                     :|..|..|..|..||| :...:|             || .|| |...|.||:..|.
pombe   332 ---------VQELLSFHKFLQVVVDESFLHDETLSYAMRKAFETFINGAKGSQREAPARLIAKYI 387

  Fly   336 NELMTKRQESE--EAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSL 398
            :.|:...:::.  :.:.:....|:....:::.:..|...|...:..|.:...|.|...|.::..:
pombe   388 DYLLRVGEQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDM 452

  Fly   399 LNKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKND------GSFENF 457
            |.|...:..|..:....|||:    :.|||.......  |...:.....:.|.      .|:...
pombe   453 LKKTCGSQFTHSLEGMFRDVN----ISKEFTSSFRHS--KAAHNLHRDLYVNVLSQAYWPSYPES 511

  Fly   458 NLTLPDELQQAWKEFRIFYEARKLQSK---------AIIQLNNELSSGEITCHLNQSVYILEVST 513
            ::.|||::||....|..||.::::..|         .|::....|.:.|           |.:|.
pombe   512 HIRLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNKE-----------LSISL 565

  Fly   514 LQMAVLMLFNR---HERFTEQEL--VTALG-VEL-ETLQE-ALKQIKFLVYIEVNKV----NYIE 566
            .|..||:.||.   .|..:.|:|  .|.|. ::| .|||. :..:|:.||.:..:|.    ....
pombe   566 FQACVLLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKPSPDTMFY 630

  Fly   567 INMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKIRRDKQ--VDAAIVRIMKGQKQLEYSELISL 629
            :|..||::..|:..|:...::.|  :|.|:::.::.||:|  :.|:|||:||.::::::.:|:..
pombe   631 VNEKFTDKLYRVKINQIYLKEER--QENSDVQEQVVRDRQFELQASIVRVMKQKEKMKHDDLVQY 693

  Fly   630 VYEELKDRVKPQVSFIKKRLDYLVEREYLER-DNYYNIYRYL 670
            |...:|||..|.||.:|..::.|:|:||||| ||  :||.|:
pombe   694 VINNVKDRGIPLVSDVKTAIEKLLEKEYLEREDN--DIYTYV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	159/731 (22%)
		CULLIN	362..500	CDD:214545	30/152 (20%)
		Cullin_Nedd8	606..661	CDD:287520	23/57 (40%)
pcu4	NP_594195.1	COG5647	1..734	CDD:227934	164/757 (22%)
		CULLIN	416..554	CDD:214545	28/143 (20%)
		Cullin_Nedd8	663..730	CDD:214883	27/68 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810