DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul3

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_592949.1	Gene:	cul3 / 2542637	PomBaseID:	SPAC24H6.03	Length:	785	Species:	Schizosaccharomyces pombe

Alignment Length:	795	Identity:	168/795 - (21%)
Similarity:	286/795 - (35%)	Gaps:	183/795 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILQ-VVNQIFDDYTSFDGQKLMHLYHLIYKQCAAERNWNNP----AQKNGRSLYIVLSDCLMKRL 80
            :|| .:..||...||               |.:.|..:.|.    ..|.|..||..:.|.:..||
pombe    28 VLQRAIGDIFQKSTS---------------QLSFEELYRNAYILVLHKYGEKLYNHVQDVIRSRL 77

  Fly    81 KN----------IAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNW----VER 131
            |.          .|.::.|.|.|   ||....|...|   .||.|..:........:|    |..
pombe    78 KEETVPAIYKNYDASLLGNALLD---IRKNDSYSTSW---SRSLEAAHRFLSSLVNSWKDHIVSM 136

  Fly   132 ERLKG-----DK------ETYPIYRLAMISWKELVFEPSV--------TILAAIRL--------- 168
            :.:..     ||      :..|:....:..::|:|...|.        |||..:.|
pombe   137 QMISSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILILVYLERKGNTINR 201

  Fly   169 --------ILSQMPREYNKSLEYQV-------------YQVLQSIV------------------- 193
                    :|:.:|.|..|...|.|             |::..|.|
pombe   202 PLINDCLDMLNSLPSENKKETLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEE 266

  Fly   194 ELYANDKYQDVSLPSRI-----DKIFTEKVMDFYKSTTLHEFQKIVVSN------DYKDFKHFLR 247
            |...:..|....:.|.:     |::.::.:.|..::.:...|..|..||      .|:.|.
pombe   267 EKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVYESFS---- 327

  Fly   248 YACLAMPEIENGTQFKAILKRYLAARL-QETRLSGKDYIQAFLG-LCRGPL-----------QRA 299
                   .:|.|.:   .||:|||..: ...:|..:...||..| :..|.|           |:.
pombe   328 -------RVELGVK---SLKKYLAKYVAHHGKLINETTSQALEGKMAVGRLSSNATMATLWVQKV 382

  Fly   300 LRDHTKLAEVVDAVCKEEINRKGQIIDPTRLLV---TYANELMT----------KRQESEEAIID 351
            |....:|..::......:.:....:.|.....|   |.|.|.::          .|:..|.:|..
pombe   383 LALWDRLNTIISTTMDADRSILNSLSDAFVTFVDGYTRAPEYISLFIDDNLKKDARKAIEGSIEA 447

  Fly   352 ELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLR 416
            .|:..|....|:|::..|...|...|..|.:|..|.|...|..|.|.|.::..|..|:.:.....
pombe   448 TLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKLEGMFN 512

  Fly   417 DVDKLRTLKKEFQDHLNSKGIKLGFDFRPKCFKN-----DGSFENFNLTLPDELQQAWKEFRIFY 476
            |::..:.|.:|::.:...:..|...|.......:     |.|........|..|.....:|..||
pombe   513 DMNLSQELLQEYKHNSALQSAKPALDLNVSILASTFWPIDLSPHKIKCNFPKVLLAQIDQFTDFY 577

  Fly   477 EARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLF---NRHERFTEQELVTALG 538
            .::....|.:  ....:.|.::..:.....|.|.|||:...:|:||   ..::....:|::....
pombe   578 LSKHTGRKLL--WYPSMGSADVRVNFKDRKYDLNVSTIASVILLLFQDLKENQCLIFEEILEKTN 640

  Fly   539 VELETLQEALKQI---KFLVYI------EVNKVNYIEINMDFTNRKRRLFCNEPLPRKMRKIEEK 594
            :|:..|:..|:.:   |:.:.:      |||..:....|.:|.:...|:..:.....::....|:
pombe   641 IEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARIKISTVAQTRVEDDSER 705

  Fly   595 SEIELKI--RRDKQVDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREY 657
            .....|:  .|..|.||.|||:||.:|..|:::|::.|..:|..|..|....||:|::.|:||||
pombe   706 KRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRRIEALIEREY 770

  Fly   658 LER--DNYYNIYRYL 670
            |:|  || ..||.||
pombe   771 LQRQADN-GRIYEYL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	164/788 (21%)
		CULLIN	362..500	CDD:214545	29/142 (20%)
		Cullin_Nedd8	606..661	CDD:287520	25/56 (45%)
cul3	NP_592949.1	COG5647	1..785	CDD:227934	168/795 (21%)
		CULLIN	458..601	CDD:214545	29/144 (20%)
		Cullin_Nedd8	717..777	CDD:287520	25/59 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810