DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul6 and cul1

DIOPT Version :9

Sequence 1:	NP_648620.1	Gene:	Cul6 / 39474	FlyBaseID:	FBgn0036332	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_594259.1	Gene:	cul1 / 2542393	PomBaseID:	SPAC17G6.12	Length:	767	Species:	Schizosaccharomyces pombe

Alignment Length:	786	Identity:	191/786 - (24%)
Similarity:	325/786 - (41%)	Gaps:	166/786 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FDSMLPLIDNILQVVNQIFDDYTSFDGQ---KLMHLYHLIYKQCA-AER-----NWNN-PAQKNG 65
            :||:....|.:...|:|||:...  :|.   |.|.||..|:..|| |.:     |:|: .|...|
pombe    17 YDSLNGTWDFLKTGVSQIFERLD--EGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLG 79

  Fly    66 RSLY---IVLSDCLMKRLKNIAWVMENQLDDNKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRN 127
            .:||   ::..:..:.||:.......|..:.      :|.|.::|..:..|...:|....:.||.
pombe    80 EALYNNLVLYLEEYLARLRKECISQTNHEEQ------LAAYAKYWTRFTTSARFINHLFGYLNRY 138

  Fly   128 WVERERLKGDKETYPIYRLAMISW---------------------KELVFEP-----------SV 160
            ||:.:....:...|.||.|.::||                     |:.::||           |:
pombe   139 WVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSI 203

  Fly   161 TILA---------------------------------AIRLILSQMPREYNKSLEYQVYQVLQSI 192
            |.|:                                 :...:.|....:|.|..|.::.:. :.:
pombe   204 TSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEE-EEL 267

  Fly   193 VELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLH-EFQKIVVSNDYKDFKHFLRYACLAMPEI 256
            |.||.::......|.:      ||.|:.......|| :|.:::..|..:|.....|    .|...
pombe   268 VRLYLHESTLKPLLEA------TEDVLIAQHEEVLHNDFARMLDQNCSEDIIRMYR----LMSRT 322

  Fly   257 ENGTQ-----FKAILKRYLAARLQ--------ETRLSGKDYIQAFLGLCRGP---LQRALRDHTK 305
            .||.|     |:..:||...|.:.        |..:..|:|::..|...:..   :..|....|.
pombe   323 PNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTD 387

  Fly   306 LAEVVDAVCKEEINR-----KGQIIDPTRLLVTYANELMTKRQESEEA--IIDELKRIVKCVEFL 363
            ..:.:|...:|.:||     :.....| .||..||:.::.|..::.:.  :.|.|..|:....::
pombe   388 FTKSLDTAFRELVNRNVVCQRSSSRSP-ELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYV 451

  Fly   364 SDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANF-VTRCIYVQLRDVDKLRTLKKE 427
            .|:..|.:.|.|.|..|.:|.||.|...||.|.|.| |::..| .|..:....:|:...:.:.:.
pombe   452 EDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKL-KEVCGFEYTSKLQRMFQDISLSQEITEA 515

  Fly   428 F-------QDHLNSKGIKLGFDFRPKCFKNDGSFENFNLTLPDELQQAWKEFRIFY----EARKL 481
            |       ..:::...:.||..|.|.      |..|.|..||:||...::.|:.:|    ..|||
pombe   516 FWQLPQSRAGNIDFSALVLGTSFWPL------SPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKL 574

  Fly   482 QSKAIIQLNNELSSGEITCHLNQS---VYILEVSTLQMAVLMLFNRHERFTEQELVTALGVELET 543
            ....      .||.|||...:|..   .|:.:|||.||.||:|:|..:.:|.:||....|:..:.
pombe   575 SWLF------HLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDF 633

  Fly   544 LQEALK---QIKFLVYIEVNKV----NYIEINMDFTNRKRRLFCNEPLPRKMRKIEEKSEIELKI 601
            |...|.   :.|.|:..:.:|:    :..:||.:|..:|.|:..|  ||.:..:.:|..|....|
pombe   634 LTGILNIFLKAKVLLLGDNDKLGDPNSTYKINENFRMKKIRVQLN--LPIRSEQKQESLETHKTI 696

  Fly   602 RRDKQ--VDAAIVRIMKGQKQLEYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLE---RD 661
            ..|::  :.:|||||||.::.|::..|:....:::|.|..|:||.||:.:|.|:|:||||   ||
pombe   697 EEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQGRD 761

  Fly   662 NYYNIY 667
            .|  ||
pombe   762 EY--IY 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	188/772 (24%)
		CULLIN	362..500	CDD:214545	41/149 (28%)
		Cullin_Nedd8	606..661	CDD:287520	23/59 (39%)
cul1	NP_594259.1	COG5647	1..767	CDD:227934	191/786 (24%)
		CULLIN	450..589	CDD:214545	41/151 (27%)
		Cullin_Nedd8	696..763	CDD:214883	27/66 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870