DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul6 and CUL9

DIOPT Version :10

Sequence 1:NP_648620.1 Gene:Cul6 / 39474 FlyBaseID:FBgn0036332 Length:670 Species:Drosophila melanogaster
Sequence 2:XP_011512724.1 Gene:CUL9 / 23113 HGNCID:15982 Length:2566 Species:Homo sapiens


Alignment Length:727 Identity:139/727 - (19%)
Similarity:240/727 - (33%) Gaps:240/727 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 DGQKLMHLYHLIYKQCAAERNW-------NNPAQKNGRSLYIVLSDCLMKRLKN--------IAW 85
            |.::|:.|...:.:....|:|:       :..||..|::.:..|...|::.:.:        :.|
Human  1332 DHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGW 1396

  Fly    86 VMENQLDDNK----PIRLIAKYLEHWVPYQRSCEKLNLACYH---------------FNRNWVER 131
            :::..|:..:    |:...|.:...   .:|.|..|    .|               |::|...|
Human  1397 LLDQYLEQRETSRNPLSRAASFASR---VRRLCHLL----VHVEPPPGPSPEPSTRPFSKNSKGR 1454

  Fly   132 ERLKGDKETYPIYRLAMIS--WKELVFEPSVTILAAIRLILSQMPREYNKSLEYQVYQVLQSI-V 193
            :|........|...|..|:  |..:|.|.....|||.......:|| |.|     :|:.||.. .
Human  1455 DRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPR-YCK-----LYEHLQRAGS 1513

  Fly   194 ELYANDKYQDVSLPSRIDKIFTEKVMDFYKSTTLH------------EFQ-KIVVSNDYKDFKHF 245
            ||:.......::|.|.    |:..::.....|..|            .|| .:.:...:..|:..
Human  1514 ELFGPRAAFMLALRSG----FSGALLQQSFLTAAHVSPTSSPQGYKLVFQVHLFLLCPFTSFRSP 1574

  Fly   246 LRYA------------CLAMPEIENGTQFKAILKRYLAARLQETRLSGKDYIQAFLGLCRGPLQR 298
            :.|:            |..|.|     ||    .||:..::|...:.|...::..     |.|||
Human  1575 VSYSTPSFMVCSCPFPCPQMSE-----QF----ARYIDQQIQGGLIGGAPGVEML-----GQLQR 1625

  Fly   299 ALRDHTKLAEVVDAVCKEEINR---------------KGQIID------PTRLLVTYANELMTKR 342
            .|.....|:.:..|...|...:               :|.:::      |.||.......|.|..
Human  1626 HLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLMLQSLSTSE 1690

  Fly   343 QESEEAIIDELKRIVKCVEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMY--------SLL 399
            :...:..:.:|:|:.|.  ||..|.:      :..|:.:..|....:..|..::        |:|
Human  1691 ELQRQFHLFQLQRLDKL--FLEQEDE------EEKRLEEEEEEEEEEEAEKELFIEDPSPAISIL 1747

  Fly   400 NKKMANFVTRCIYVQLRDVDKLRTLKKEFQDHLNSKGIKLGFDFRP-KCFKNDGSFENFNLTLPD 463
                 ....||..|.                       .|.:.:.| ||             ||.
Human  1748 -----VLSPRCWPVS-----------------------PLCYLYHPRKC-------------LPT 1771

  Fly   464 ELQQAWKEFRIFYEA------------RKLQ----SKAIIQLNNELSSGEITCHLNQSVYILEVS 512
            |...|...|..||..            |:||    .:|.:|...:               ||.||
Human  1772 EFCDALDRFSSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQ---------------ILHVS 1821

  Fly   513 TLQMAVLMLFNRHERFTEQELVTALGVELETLQEALKQIKFLVYIEVNKVNYIEINMDFTNRKRR 577
            |:||.:|:.||:.|..:.:.|:....:..|.|.:||..:     ...|....:....||.: ...
Human  1822 TVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPL-----TSGNGPLTLHEGQDFPH-GGV 1880

  Fly   578 LFCNEPLPRKM--------------------RKIEEKSEIELKIRRDKQVDAAIVRIMK--GQKQ 620
            |..:||.|::.                    |.:|:|..:         :...:|||:|  |:|.
Human  1881 LRLHEPGPQRSGEALWLIPPQAYLNVEKDEGRTLEQKRNL---------LSCLLVRILKAHGEKG 1936

  Fly   621 LEYSELISLVYE 632
            |...:|:.||.|
Human  1937 LHIDQLVCLVLE 1948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul6NP_648620.1 COG5647 25..670 CDD:227934 139/727 (19%)
CUL9XP_011512724.1 Cul7 366..440 CDD:463286
APC10-like 1167..1297 CDD:382862
Cullin <1595..1863 CDD:459983 67/350 (19%)
Cullin_Nedd8 1913..1993 CDD:214883 13/45 (29%)
RING-HC_RBR_CUL9 2117..2169 CDD:438286
BRcat_RBR_CUL9 2195..2268 CDD:439008
Rcat_RBR_CUL9 2276..2333 CDD:439020
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.