Protein Alignment Cul6 and cul-5

DIOPT Version :10

• Sequence 1: NP_648620.1
• Gene: Cul6 / 39474
• FlyBaseID: FBgn0036332
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_505616.2
• Gene: cul-5 / 179413
• WormBaseID: WBGene00000840
• Length: 765
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 154/746 - (20%)
• Similarity: 278/746 - (37%)
• Gaps: 195/746 - (26%)

  Fly    81 KNIAWVMENQL---------------DDNKPIR-------LIAKYLEHWVPYQRSCEKLNLACYH 123
            |..:||.:..|               :.||.||       |:..|::.|   .|..::.|:....
 Worm    37 KITSWVDDGPLKIRDILTRCINDYVHEANKRIRSLQTDGSLLIGYIKEW---NRFYQQANILPLP 98

  Fly   124 FNR-NWVERERLKGDKETYPIYRLAMISWKELVFE--PSVTILAAIRLI---------------- 169
            |.: :...|.|...:.....|..:.:..|.|::|.  ....::.|:||:
 Worm    99 FKKIDESSRRRSVPETPEESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIG 163

  Fly   170 ----------------------------LSQMPREYNK----------SLEYQVYQVLQSIVELY 196
                                        :.|....|.|          .|||.||...:...|..
 Worm   164 IRESFVALNDRAGEDPLLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQ 228

  Fly   197 ANDKYQDVSLPS---RIDKIFTEKVMDFYKSTTLHEFQKIVVSNDYKDFKHFLRYACLAMPEIEN 258
            ...:|.:::.|:   .::|.....|..| :.|.|.|..|::.|.|.:..:...|........|:
 Worm   229 RAKRYLEMNSPTSGKHMEKAVIALVESF-EDTILAECSKLIASKDVERLQRLYRLIRRTRSGID- 291

  Fly   259 GTQFKAILKRYLAARLQETRLSGKD-------YIQAFL------------GLCRGPLQRALRDHT 304
             |..|.|........|.:.|.:.::       |:|..|            |.|........||..
 Worm   292 -TVLKCIDTHIRTEGLNDMRNNAENLSTDPERYVQQLLLMFDKFSSLVREGFCDDARLLTARDKA 355

  Fly   305 KLAEVVD-AVCKEE-INRKGQIIDP----TRLLVTYANELMTKRQESE----EAIIDELKRIVKC 359
            ..|.|.| ::.|.| :|:||:.:..    ..||..|.:.|:.|.|.|:    |.|.::|.:::..
 Worm   356 FRAVVNDSSIFKTEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLV 420

  Fly   360 VEFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNK-----KMANFVTRCIYVQLRDVD 419
            ::::.::..|:..:...|..|.|.|.|.....|.:|.:.|.:     ...|.::|    .|:|::
 Worm   421 LKYVENKDVFMRFHRAHLSRRLILEMSADQEKEEMMVTKLRECGMPSDAVNKLSR----MLQDIE 481

  Fly   420 KLRTLKKEFQDHL----NSKGIKLGFDFRPKCFKNDGSF-----ENFNLTLPDELQQAWKEFRIF 475
            ..:.:...|:..|    |:|.|....:.:   ..|.|::     |....:||.||:....|...|
 Worm   482 LNKDMNSSFKKALTGTNNNKSIADSINMK---VLNGGAWGRGGSERIRFSLPRELEDFVPEMEAF 543

  Fly   476 YEARKLQSKAIIQLNNELSSGEITCHLNQSVYILEVSTLQMAVLMLFN--RHERFTEQELVTALG 538
            |: ::...:.:..:::..|...:....|...:.||.:|.|||||..||  .|::
 Worm   544 YK-KQHNGRKLCWMHHWSSGTMVFGTANGGRFDLECTTFQMAVLFCFNDRAHDK----------- 596

  Fly   539 VELETLQEALKQIKFLVYIEVNK-----VNYIEIN---------------MDFTNRKRRLFCNEP 583
            :.||||:.|.:    |...|:|:     |.|.::.               .|||:..:.|..::.
 Worm   597 ISLETLRLATE----LPDAELNRTLLSLVAYPKMRYQILLCDVPSTTVTARDFTDSTKFLINHDF 657

  Fly   584 LPRKMRKIEEKSEIELKIR-------------------RDKQVDAAIVRIMKGQKQLEYSELISL 629
            ...|..|.:::.::.|..|                   |:.:|...||:|:|.:|....::|...
 Worm   658 NVVKNGKSQQRGKVNLIGRLQLSLEANAEKEHESIVALRELRVQEGIVKILKTRKTYTLAQLTME 722

  Fly   630 VYEELKDRVKPQVSFIKKRLDYLVEREYLER 660
            :.|.||....|....||:::|:|:|.:|:||
 Worm   723 LVEILKPLFIPNRKIIKEQIDWLIENKYMER 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul6	NP_648620.1	COG5647	25..670	CDD:227934	154/746 (21%)
cul-5	NP_505616.2	Cullin	7..657	CDD:459983	130/648 (20%)
		Cullin_Nedd8	692..759	CDD:214883	20/62 (32%)